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尿素(13C,15N2)
NMR and HPLC COA下载 MSDS下载 - Names：
Urea(13C,15N2)|碳/氮标记尿素
- CAS号：
78405-35-3
MDL Number： - MF(分子式)： H2(15-N)(13-C)O(15-N)H2 MW(分子量)： 63.035g/mol
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| HCQ000125-1g | 1g | 丰度98% | ¥ 0.00 | ¥ 0.00 | Instock | ¥ 0.00 | ||
| HCQ000125-100mg | 100mg | 丰度98% | ¥ 7800.00 | ¥ 7800.00 | Instock | ¥ 0.00 | ||
| HCQ000125-50mg | 50mg | 丰度98% | ¥ 5200.00 | ¥ 5200.00 | Instock | ¥ 0.00 | ||
| HCQ000125-20mg | 20mg | 丰度98% | ¥ 2800.00 | ¥ 2800.00 | Instock | ¥ 0.00 | ||
| HCQ000125-5mg | 5mg | 丰度98% | ¥ 780.00 | ¥ 780.00 | Instock | ¥ 0.00 |
| 中文别名 | 尿素(13C,15N2),尿素同位素,碳/氮标记尿素,氮标记尿素,碳标记尿素,碳13标记尿素(13C,15N2+);(78405-35-3);尿素碳氢同位素,同位素尿素,碳氮双标记尿素;脲-13C,15N2 |
| 英文别名 | Urea(13C,15N2);Urea-13C,15N2;UREA(13C;15N2+):(78405-35-3),Aquacare-13C,15N2; Aquadrate-13C,15N2; B-I-K-13C,15N2; Basodexan-13C,15N2; Benural 70-13C,15N2; Carbamide-13C,15N2; Carbamimidic Acid-13C,15N2; Carbonyl Diamide-13C,15N2; Carmol 40-13C,15N2; Keratinamin-13C,15N2; Urepearl-13C,15N2; |
| CAS号 | 78405-35-3 |
| Inchi | InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)/i1+1,2+1,3+1 |
| InchiKey | XSQUKJJJFZCRTK-VMIGTVKRSA-N |
| 分子式 Molecular Weight | H2(15-N)(13-C)O(15-N)H2 |
| 分子量 Formula | 63.035g/mol |
| 溶解度Solubility | DMSO (Slightly), Methanol (Slightly); Water: 480 g/l at 20 °C (68 °F) - completely soluble |
| 性状 | White to Off-White Solid |
| 储藏条件 Storage conditions | 4°C条件下存储,-4摄氏度存储更佳 |
尿素（13C,15N2+）碳氮标记尿素合成路线，参考尿素：
尿素同位素合成路线2（参考尿素）：
尿素（13C,15N2+）(78405-35-3)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净后，烘干消毒存放。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
tags:尿素碳源同位素,尿素氮源同位素,尿素碳氮源同位素,尿素同位素,碳源尿素同位素,碳氮源尿素同位素,内标用尿素同位素,尿素内标
| 产品说明 | 尿素(13C,15N2)(78405-35-3):碳\氮标记尿素是碳标记尿素,和氮源标记尿素，同位素尿素13C,1515N2+选择性的细胞周期蛋白依赖性激酶（CDK）4/6抑制剂,78405-35-3其他参数见主页 |
| Introduction | UREA(13C;15N2+):(78405-35-3) used for scientific research and chemical synthesis intermediates |
| Application1 | 尿素同位素（13C；15N2+）是尿素的碳源和氮源同位素产品 |
| Application2 | Urea-13C,15N2 is an isotope of urea |
| Application3 |
Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic.
尿素是由一氧化碳和氨在硫的存在下反应制得的。 该反应已应用于尿素13C，尿素12C和尿素13C-15N2的合成。
Urea has been prepared from the reaction of carbon monoxide and ammonia in the presence of sulfur. The reaction has been applied to the synthesis of urea‐13C, urea‐12C, and urea‐13C‐15N2.
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | No data available |
| 安全声明 | H303+H313+H333 |
| 安全防护 | P264+P280+P305+P351+P338+P337+P313 |
| 备注 | 手套,防护服,面罩,实验过程中防止吸入、食入，做好安全防护 |
尿素 (13C, 99%; 15N2, 98%+)毒性,UREA(13C; 15N2）Toxicity:
LC50 fish 1 17500 mg/l Poecilia reticulata (guppy) - 96 h EC50 Daphnia 1 3910 mg/l Daphnia magna (Water flea) - 48 h
尿素同位素Urea(13C,15N2)废弃物处理：Disposal considerations. Waste treatment methods Regional legislation (waste) : Waste materials should be disposed of under conditions which meet Federal, State, and Local environmental control regulations. Waste disposal recommendations : Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Ecology - waste materials : Dispose of as unused product.
Other information :
NFPA health hazard : 0 - Exposure under fire conditions would offer no hazard beyond that of ordinary combustible materials.
NFPA fire hazard : 0 - Materials that will not burn. NFPA reactivity : 0 - Normally stable, even under fire exposure conditions, and are not reactive with water.
尿素同位素(13C;15N2)防护：
| Demetriou, A., et al.: Science, 233, 1190 (1986), Aebischer, P., et al.: Nat. Med., 2, 696 (1996), Prakash, S., et al.: Biotechnol. Bioeng., 46, 621 (1995), |
| Rodolfo A. Martinez, David R. Glass, Erick G. Ortiz, Marc A. Alvarez, Clifford J. Unkefer, Synthesis of isotopically labeled 1,3‐dithiane, Journal of Labelled Compounds and Radiopharmaceuticals, 10.10 |
| R. E. London, T. E. Walker, T. W. Whaley, N. A. Matwiyoff, Nitrogen‐15 n.m.r. studies of 13C, 15N labeled arginine, Organic Magnetic Resonance, 10.1002/mrc.1270091011, 9, 10, (598-600), (2005). |
| Effects of fatty acids on hepatic amino acid catabolism and fibrinogen synthesis in young healthy volunteers. |
| Systemic prostaglandin E1 infusion and hepatic aminonitrogen to urea nitrogen conversion in patients with type 2 diabetes in poor metabolic control. |
Estimation of urea production rate with [15N2]urea and [13C]urea to measure catabolic rates in diabetes mellitus,E J Freyse 1, S Knospe，Affiliations expand，PMID: 9854845
Abstract：For verifying catabolic states in insulin-dependent patients and dogs the method estimating urea production rates with 13C and with doubly 15N labeled urea, respectively, has been established. For a fast steady state of urea tracer dilution, a prime of 600 times the continuous infusion rate had to be injected. Urea was isolated from plasma samples by protein precipitation and cation exchange chromatography with a consecutive derivatization of the dried urea fraction (trimethylsilyl derivatives). The masses of the fragment ions m/z 189 (14N14N), 190 (14N15N) and 191 (15N15N) urea are monitored to estimate the [15N2] urea frequency in the overall body urea pool in mol percent excess (MPE). 1 to 15 ng of derivatized urea were measured efficiently. An excellent correlation between expected standard and measured MPE (r = 0.9977) was achieved from solutions containing 1 to 7% [15N2]urea. The interassay coefficient of variation amounted to < 10% for a [15N2]urea portion of > or = 3%. Normoglycemic diabetic patients who were treated with insulin overnight showed significantly higher urea production compared to healthy controls (9.22 +/- 2.07 vs. 5.4 +/- 0.32 mumol.kg-1.min-1; p < 0.05). Measurements in chronic diabetic dogs proved an increased rate of amino acid catabolism (+20% urea production) in systemic versus portal application of insulin in paired studies. This increased nitrogen load in diabetics may accelerate progression of diabetic nephropathy. Thus, the established stable isotope technique may serve as a sensitive and useful indicator of amino acid catabolism in clinical and experimental research.
Syntheses with stable isotopes: Urea‐13C, urea‐12C, and urea‐13C‐15N2Thomas W. Whaley Donald G. Ott，First published: 1975.
Abstract：Urea has been prepared from the reaction of carbon monoxide and ammonia in the presence of sulfur. The reaction has been applied to the synthesis of urea‐13C, urea‐12C, and urea‐13C‐15N2.
Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones
The present invention provides a compound of formula I 1or a pharmaceutically acceptable salt thereof wherein A, X, Y, Z, R2, R3, R4, R5, and R6 are as defined herein. The compounds of formula I are useful as antimicrobials against a number of human and veterinary pathogens.
The 13C urea breath test in the diagnosis ofHelicobacter pylori infection；V Savarinoa, S Vignerib, G Cellea.
The urea breath test (UBT) is one of the most important non-invasive methods for detecting Helicobacter pylori infection. The test exploits the hydrolysis of orally administered urea by the enzyme urease, which H pylori produces in large quantities. Urea is hydrolysed to ammonia and carbon dioxide, which diffuses into the blood and is excreted by the lungs. Isotopically labelled CO2 can be detected in breath using various methods.
Labelling urea with 13C is becoming increasingly popular because this non-radioactive isotope is innocuous and can be safely used in children and women of childbearing age. Breath samples can also be sent by post or courier to remote analysis centres. The test is easy to perform and can be repeated as often as required in the same patient. A meal must be given to increase the contact time between the tracer and the H pylori urease inside the stomach. The test has been simplified to the point that two breath samples collected before and 30 minutes after the ingestion of urea in a liquid form suffice to provide reliable diagnostic information. The cost of producing 13C-urea is high, but it may be possible to reduce the dosage further by administering it in capsule form.
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