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三羟甲基氨基甲烷
NMR and HPLC COA下载 MSDS下载 - Names：
Tris
- CAS号：
77-86-1
MDL Number： MFCD00004679 - MF(分子式)： C4H11NO3 MW(分子量)： 121.14
- EINECS:201-064-4 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
三羟甲基氨基甲烷（Tris,77-86-1）是伯氨基化合物，Tris为叔丁胺，其中连接至每个甲基的一个氢被羟基取代。在pH7-9范围内广泛用作生物缓冲物质的化合物； 在20℃下pKa＝8.3。在37℃下pKa＝7.82。Tirs具有缓冲作用,Tirs是三醇和伯氨基化合物,Tirs是Htris成员的共轭碱基。
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| SS4096-500g | 500g | 99.9%生物技术级 | ¥ 560.00 | ¥ 560.00 | Instock | ¥ 0.00 | ||
| SS4095-500g | 500g | 超纯级 | ¥ 420.00 | ¥ 420.00 | Instock | ¥ 0.00 | ||
| SS1426-25kg | 25kg | 98% | ¥ 5000.00 | ¥ 5000.00 | Instock | ¥ 0.00 | ||
| SS4095-100g | 100g | 超纯级 | ¥ 126.00 | ¥ 126.00 | Instock | ¥ 0.00 | ||
| SS1426-1kg | 1kg | 98% | ¥ 380.00 | ¥ 380.00 | Instock | ¥ 0.00 | ||
| SS1426-500g | 500g | 98% | ¥ 200.00 | ¥ 200.00 | 120 | Instock | ¥ 0.00 | |
| SS1426-100g | 100g | 98% | ¥ 80.00 | ¥ 80.00 | Instock | ¥ 0.00 |
| 中文别名 | 三羟甲基氨基甲烷;三(羟甲基)氨基甲烷(77-86-1);Tris碱;tris-base;氨丁三醇;缓血酸胺三(羟甲基)氨基甲烷;缓血酸铵 |
| 英文别名 | Tris,Trometamol,Tris(hydroxymethyl)aminomethane(CAS:77-86-1),Tris(Hydroxymethyl)aminomethane,TROMETHAMINE |
| CAS号 | 77-86-1 |
| Inchi | InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2 |
| InchiKey | LENZDBCJOHFCAS-UHFFFAOYSA-N |
| 分子式 Molecular Weight | C4H11NO3 |
| 分子量 Formula | 121.14 |
| 溶解度Solubility | 溶于水, |
| 性状 | Solid 白色晶体 |
| 储藏条件 Storage conditions | 密封保存。 |
Tris,三羟甲基氨基甲烷,的毒理性质：
| 动物 | 测试类型 | 途径 | 实验摄入量(标准摄入量) | 影响 | Tris实验数据来源 |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 1210mg/kg (1210mg/kg) | Acta Biologica et Medica Germanica. Vol. 17, Pg. 217, 1966. | |
| rabbit | LDLo | oral | 1gm/kg (1000mg/kg) | BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS |
Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940. |
| rat | LD50 | intravenous | 1800mg/kg (1800mg/kg) | Drugs in Japan Vol. -, Pg. 419, 1990. | |
| rat | LD50 | oral | 5900mg/kg (5900mg/kg) | Bollettino Chimico Farmaceutico. Vol. 110, Pg. 653, 1971. |
Tris,三羟甲基氨基甲烷,物理性质：
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 171.5 | deg C | EXP | |
| pKa Dissociation Constant | 8.069 | (none) | EXP | |
| log P (octanol-water) | -1.560 | (none) | EST | |
| Water Solubility | 5.50E+05 | mg/L | 25 | EXP |
| Vapor Pressure | 2.20E-05 | mm Hg | 25 | EST |
| Henry's Law Constant | 8.67E-13 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 3.35E-11 | cm3/molecule-sec | 25 | EST |
Tris 三羟甲基氨基甲烷图谱：
1,4,8-Tris(trifluoroacetyl) cyclam 406939-92-2
Tris-磷酸电泳缓冲液 Tris-phosphate running buffer
Tris-磷酸电泳缓冲液 Tris-phosphate running buffer
Tris-乙酸电泳粉剂 Tris-acetic acid electrophoresis powder
Tris平衡酚 Tris balanced phenol
三羟甲基氨基甲烷（Tris,77-86-1）实验注意事项：
1.使用77-86-1实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品77-86-1的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品77-86-1时尽量采用多个药勺分别使用，使用后清洗干净。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
大规格定制：定制产品请将信息发送至sales@bio-fount.com。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
| 产品说明 | 三羟甲基氨基甲烷(77-86-1,Tris)也称为tris碱,在pH7-9范围用作生物缓冲物质,Tris为叔丁胺类化合物,Tris物理性质,Tris毒理性质见主页。 |
| Introduction | Tris（三羟甲基氨基甲烷,77-86-1）is a primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. |
| Application1 | Tris生物缓冲剂，缓冲范围pH7.0-9.0 |
| Application2 | Tris酸性气体吸收剂 |
| Application3 | Tris可应用于配置生物缓冲液 |
Tris 的英文介绍：
Tris is a primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 7--9; pKa = 8.3 at 20 ℃; pKa = 7.82 at 37 ℃. It has a role as a buffer. It is a triol and a primary amino compound. It is a conjugate base of a member of Htris.
Tromethamine, also known as trometamol or tham, belongs to the class of organic compounds known as 1, 2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom. Tromethamine is a drug which is used for the prevention and correction of metabolic acidosis. Tromethamine exists as a solid, soluble (in water), and a very weakly acidic compound (based on its pKa). Tromethamine is also a parent compound for other transformation products, including but not limited to, bis-tris, bis-tris propane, and N-tris(hydroxymethyl)methylglycine.
Tris Buffers
A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer.Tris，
※ Tris 也称为THAM或三羟甲基氨基甲烷，属于1，2-氨基醇。 2-氨基醇是含有烷基链的有机化合物，该烷基链具有结合至C 1原子的胺基和结合至C 2原子的醇基。 Tris是水中可溶行化合物，水溶液相对中性。
※ Tris是伯氨基化合物，为叔丁胺，其中连接至每个甲基的一个氢被羟基取代。 在7--9的pH范围内广泛用作生物缓冲物质的化合物； 在20℃下pKa ＝ 8.3。 在37℃下pKa ＝ 7.82。 它具有缓冲作用。它是三醇和伯氨基化合物，它是Htris成员的共轭碱基。
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | Not Available |
| 安全声明 | H315,H319,H335 |
| 安全防护 | P261,P305+P351+P338 |
| 备注 | 避免吸入，误食以及与皮肤接触 |
| McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 2647 |
| Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 |
| Synthesis and Antioxidant Activity of Some New Binary Pyrazoles Containing Core Phenothiazine Moiety.DOI: 10.1002/jhet.2716 |
| Synthesis of Sterically Protected Isoindoles from ortho-Phthalaldehyde.DOI:10.1055/s-0036-1591932 |
Braunlich H; Arch Int Pharmacodyn Ther 216 (1): 144-59 (1975);PMID:240333
In rats of different age (5 to 240 days old) the renal excretion of Trishydroxymethylaminomethane (THAM) was studied. In 5 and in 240 days old rats the renal excretion of THAM was slower than in rats of other age groups. Stimulation of diuresis by i.p. injection of mannitol, thiazide or by oral water load resulted in an increase in THAM excretion in 5 and in 240 days old rats. The renal excretion of THAM was also increased by repeated administration of THAM in all age groups, except in new born rats. Possible mechanisms of action are discussed.
Rothe KF, Heisler N; Anasth Intensivther Notfallmed 19 (1): 24-6 (1984);PMID:6711774
The distribution of 14C labelled THAM (tris-hydroxymethylaminomethane) was determined between intra- and extracellular space of nephrectomized Sprague-Dawley rats as a function of time at constant plasma pH of 7.4. The following results were obtained: An equilibrium in the distribution of THAM between ECS and ICS will not occur before 6-12 hours after administration. This indicates that THAM permeates very slowly into the intracellular compartment, which is in contrast to the general assumption that it quickly diffuses into the intracellular space to restore the intracellular acidosis. THAM disappears from the extracellular space in a multiexponential fashion, indicating that it equilibrates with the different body tissues at largely variable rates. The equilibrium which occurs between both body compartments 6-12 hours after THAM application does not agree with the values which are expected for transfer of only the nonionised substance. At plasma pH 7.4 and a "mean whole body pHi" of 6.88, THAM is distributed with a distribution ratio of 4 (ICS/ECS), a value quite different from the value of 11 which would be expected for exclusive nonionic diffusion. Thus THAM is also transferred across the cell membrane in ionized form. These results indicate that the influx of THAM into the intracellular space is too slow (when compared to the renal elimination kinetics) to influence intracellular pH significantly by direct buffer action. Moreover, only a fraction of THAM enters the intracellular space in the nonionized form, thus reducing (to an even greater extent) the direct effect of THAM on the intracellular acid-base equilibrium.
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