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氨(Ammonia ,7664-41-7)是一种无机化合物,由一个酰胺原子抑制剂和神经毒素共价键合到三个氢原子的单个氮原子组成。 它是通过细菌过程和有机物分解自然产生和生产的。 氨在许多工业过程中用作肥料和制冷剂。 它的特征是无色气体或压缩液体,带有刺激性气味,并且通过吸入,摄入或接触而发生暴露。氨是自然发生的,是人类活动产生的。它是动植物所需的重要氮源。在肠道中发现的细菌会产生氨。氨是一种无色气体,具有非常明显的气味。这种气味为许多人所熟悉,因为氨被用于闻盐,许多家用和工业清洁剂以及窗户清洁产品中。氨气可溶于水。这种氨称为液氨或氨水。一旦暴露在露天环境中,液氨很快就会变成气体。氨直接施用到农田的土壤中,并用于制造农作物,草坪和植物的肥料。许多家庭和工业清洁剂都含有氨。
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中文别名 氨(7664-41-7);氨溶液;水质氨;液氨;氨气(液氨),无水氨
英文别名 Ammonia (7664-41-7);Ammonia solution;Ammoniac; Ammoniaca; Ammoniak ; Anhydrous ammonia
CAS号 7664-41-7
Inchi InChI=1S/H3N/h1H3
InchiKey QGZKDVFQNNGYKY-UHFFFAOYSA-N
分子式 Molecular Weight NH3
分子量 Formula 17.03
溶解度Solubility Miscible with water
性状 Colorless gas with a pungent, suffocating odor.
储藏条件 Storage conditions 储存温度2-8℃
氨(Ammonia ,7664-41-7)毒理性质:
动物 测试类型 途径 实验摄入量 (标准摄入量) 影响 文献来源
cat LC50 inhalation 7gm/m3/1H (7000mg/m3) BEHAVIORAL: EXCITEMENT

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 29, 1944.
human LCLo inhalation 5000ppm/5M (5000ppm)   Tabulae Biologicae. Vol. 3, Pg. 231, 1933.
human TCLo inhalation 20ppm (20ppm) SENSE ORGANS AND SPECIAL SENSES: ULCERATED NASAL SEPTUM: OLFACTION

SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE

LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 13, Pg. 528, 1955.
mammal (species unspecified) LCLo inhalation 5000ppm/5M (5000ppm)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 138, Pg. 65, 1928.
man LDLo unreported 132mg/kg (132mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo oral 15uL/kg (0.015mL/kg) GASTROINTESTINAL: CHANGE IN STRUCTURE OR FUNCTION OF ESOPHAGUS American Journal of Emergency Medicine. Vol. 3, Pg. 320, 1985.
mouse LC50 inhalation 4230ppm/1H (4230ppm) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 41, Pg. 1568, 1982.
rabbit LC50 inhalation 7gm/m3/1H (7000mg/m3) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: EXCITEMENT
Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 29, 1944.
rat LC50 inhalation 2000ppm/4H (2000ppm)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 607, 1969.

氨 (CAS:7664-41-7;英文名:Ammonia solution;)实验注意事项:
1.使用7664-41-7实验前需戴好防护眼镜,穿戴防护服和口罩,佩戴手套,避免与皮肤接触。
2.使用7664-41-7实验过程中如遇到有毒或者刺激性物质及有害物质产生,必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品7664-41-7的移液枪头需及时更换,必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸,并无风处取药和称量以免扬撒,试剂的容器使用前务必确保干净,并消毒。
5.取药品7664-41-7时尽量采用多个药勺分别使用,使用后清洗干净。
6.实验后产生的废弃物需分类存储,并交于专业生物废气物处理公司处理,以免造成环境污染。
大规格定制:定制产品请将信息发送至sales@bio-fount.com。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:氨蒸汽压,氨合成,氨标准,氨应用,氨合成,氨沸点,氨闪点,氨用途,氨溶解度,氨价格,氨作用,氨结构式,氨用处
产品说明 氨 (7664-41-7)有强烈的刺激臭味,易溶于水,氨溶于醇和乙醚,氨为无色液体,放出多量的热;这样液氨可用作致冷剂.氨 溶解度,氨结构式详见主页.
IntroductionAmmonia (氨,7664-41-7) occurs naturally and is produced by human activity.
Application1
Application2主要本产品应用于于环境监测及相关分析测试中仪器校准和绘制校准曲线
Application3
1.Ammonia is an inorganic compound composed of a single nitrogen atom covalently bonded to three hydrogen atoms that is an amidase inhibitor and neurotoxin. It is both manufactured and produced naturally from bacterial processes and the breakdown of organic matter. Ammonia is used in many industrial processes, and as a fertilizer and refrigerant. It is characterized as a colorless gas or compressed liquid with a pungent odor and exposure occurs by inhalation, ingestion, or contact.

2.Ammonia occurs naturally and is produced by human activity. It is an important source of nitrogen which is needed by plants and animals. Bacteria found in the intestines can produce ammonia. Ammonia is a colorless gas with a very distinct odor. This odor is familiar to many people because ammonia is used in smelling salts, many household and industrial cleaners, and window-cleaning products. Ammonia gas can be dissolved in water. This kind of ammonia is called liquid ammonia or aqueous ammonia. Once exposed to open air, liquid ammonia quickly turns into a gas. Ammonia is applied directly into soil on farm fields, and is used to make fertilizers for farm crops, lawns, and plants. Many household and industrial cleaners contain ammonia.

3.Ammonia, anhydrous appears as a clear colorless gas with a strong odor. Shipped as a liquid under its own vapor pressure. Density (liquid) 6 lb / gal. Contact with the unconfined liquid can cause frostbite. Gas generally regarded as nonflammable but does burn within certain vapor concentration limits and with strong ignition. Fire hazard increases in the presence of oil or other combustible materials. Although gas is lighter than air, vapors from a leak initially hug the ground. Prolonged exposure of containers to fire or heat may cause violent rupturing and rocketing. Long-term inhalation of low concentrations of the vapors or short-term inhalation of high concentrations has adverse health effects. Used as a fertilizer, as a refrigerant, and in the manufacture of other chemicals. Rate of onset: Immediate Persistence: Minutes Odor threshold: 17 ppm Source/use/other hazard: Explosives manufacture; pesticides; detergents industry.
 
警示图
危险性 warning
危险性警示 Not Available
安全声明 H221,H280,H314,H331,H400
安全防护 P210,P261,P273,P280,P305+P351+P338,P310
备注 避免吸入,误食以及与皮肤接触
Mohr, Rudolf. Ammonia separation from offgas obtained from melamine synthesis. U.S. (1971), 5 pp. CODEN: USXXAM US 3555784 19710119 CAN 77:50902 AN 1972:450902
Nitrous oxide production by ammonia oxidizers: Physiological diversity, niche differentiation and potential mitigation strategies PMID 31638306; Global change biology 2020 01; 26(1):103-118 (Review Ar
Advances in sensing ammonia from agricultural sources PMID 31855649; The Science of the total environment 2020 Mar; 706(?):135124 (Review Article) Name matches: nitrogen ammonia
Ambient Ammonia Electrosynthesis: Current Status, Challenges, and Perspectives PMID 32202392; ChemSusChem 2020 Jun; 13(12):3061-3078 (Review Article) Name matches: nitrogen ammonia
Improving the Reliability and Accuracy of Ammonia Quantification in Electro- and Photochemical Synthesis PMID 31638336; ChemSusChem 2020 Jan; 13(1):88-96 (Review Article) Name matches: ammonium ammoni
1.Novel aspects of glutamine synthetase in ammonia homeostasis/PMID 32758585; Neurochemistry international 2020 Aug; ?(?):104809 (Review Article)/Name matches: glutamine synthetase ammonia
Abstract:
Elevated blood ammonia (hyperammonemia) is believed to be a major contributor to the neurological sequelae following severe liver disease. Ammonia is cleared via two main mechanisms, the urea cycle pathway and the glutamine synthetase reaction. Recent studies of genetically modified animals confirm the importance of the urea cycle, but also suggest that the glutamine synthetase reaction is more important than previously recognized. While the liver clears about two-thirds of the body's ammonia via the combined action of the urea cycle and glutamine synthetase, extrahepatic tissues do not express all the components required for performing a complete urea cycle and therefore depend on the glutamine synthetase reaction for ammonia clearance. The brain is particularly vulnerable to the effects of hyperammonemia, which include impaired extracellular potassium buffering and brain edema. Moreover, the glutamine synthetase reaction is intimately linked to the metabolism of the excitatory and inhibitory neurotransmitters glutamate and gamma aminobutyric acid (GABA), implicating a key role for this enzyme in neurotransmission. This review discusses the emerging roles of glutamine synthetase in brain pathophysiology, particularly aspects related to ammonia homeostasis and hepatic encephalopathy.
2.Mechanistic insight, diagnosis, and treatment of ammonia-induced hepatic encephalopathy/PMID 30070387; Journal of gastroenterology and hepatology 2019 Jan; 34(1):31-39 (Review Article)/Name matches: hepatic encephalopathy ammonia
Abstract:
Hepatic encephalopathy is a neuropsychological syndrome due to biochemical disturbance of brain function in advanced liver disease patients. Diagnosis and treatment of the condition is very demanding and has negative toll on finances with increased healthcare utilization. The pathophysiology is not completely understood; however, there is evidence that ammonia plays an important role in the etiology. Conventional methods of solely relying on blood ammonia level to diagnose hepatic encephalopathy did not help much; likewise, the use of lactulose alone in treating hepatic encephalopathy has also been discouraged. This paper analyzed the current knowledge regarding the mechanism of how ammonia disrupts the normal brain function as well as the use of latest diagnosing tools including those under development to evaluate the neuropsychiatric state of patients and their quality of life. The efficacies of lactulose and rifaximin combination for short-term and long-term treatment in addition to nutritional interventions and other drugs undergoing clinical trials were also reviewed.
3.Sarcopenia: Ammonia metabolism and hepatic encephalopathy/PMID 31006226; Clinical and molecular hepatology 2019 09; 25(3):270-279 (Review Article)/Name matches: hepatic encephalopathy ammonia
Abstract:
Sarcopenia (loss of muscle mass and/or strength) frequently complicates liver cirrhosis and adversely affects the quality of life; cirrhosis related liver decompensation and significantly decreases wait-list and post-liver transplantation survival. The main therapeutic strategies to improve or reverse sarcopenia include dietary interventions (supplemental calorie and protein intake), increased physical activity (supervised resistance and endurance exercises), hormonal therapy (testosterone), and ammonia lowering agents (L-ornithine L-aspartate, branch chain amino acids) as well as mechanistic approaches that target underlying molecular and metabolic abnormalities. Besides other factors, hyperammonemia has recently gained attention and increase sarcopenia by various mechanisms including increased expression of myostatin, increased phosphorylation of eukaryotic initiation factor 2a, cataplerosis of α ketoglutarate, mitochondrial dysfunction, increased reactive oxygen species that decrease protein synthesis and increased autophagy-mediated proteolysis. Sarcopenia contributes to frailty and increases the risk of minimal and overt hepatic encephalopathy.
 
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