欢迎来到范德生物BIOFOUNT
范德生物中国

中文范德生物中文语言

搜索 结构式搜索
范德生物产品购买购物车
0
Search
搜索
登录/ 注册
首页>产品列表>

Melatonin

73-31-4 Melatonin
Melatonin, Endogenous hormone agonist at MT1 and MT2 receptors 褪黑激素是一种吲哚胺神经激素，其水平在每日周期中变化，从而可以夹带动物、植物和微生物中几种生物功能的昼夜节律。褪黑激素的许多生物学效应是通过褪黑激素受体转导的，包括 MT1、MT2、 和 MT3 亚型。褪黑激素还作为一种强大的抗氧化剂，保护脂质、蛋白质和 DNA 免受氧化损伤。谷胱甘肽过氧化物酶、超氧化物歧化酶和过氧化氢酶被褪黑激素上调，褪黑激素作为末端抗氧化剂清除自由基。
货品编码 规格 纯度 价格 (¥) 现价(¥) 特价(¥) 库存描述 数量 总计 (¥)
SY0301-5g 5g 98% ¥ 172.00 ¥ 172.00 Instock
- +
¥ 0.00
SY0301-1g 1g 98% ¥ 52.00 ¥ 52.00 Instock
- +
¥ 0.00
SY0301-25g 25g 98% ¥ 360.00 ¥ 360.00 Instock
- +
¥ 0.00
快速询价
收起
你想询价的产品
请准确填写您的联系方式，以便为您提供最好的服务。
询价
中文别名 73-31-4;褪黑素;;松果素;松果体素;3-N-乙酰基-5-甲氧基色胺;褪黑色素;褪黑激素;美拉托宁;MT1和MT2受体的内源性激素激动剂
英文别名 Melatonin;Melatonine;MLT;Circadin;Melovine;Endogenous hormone agonist at MT1 and MT2 receptors;NSC56423; NSC113928; Regulin
CAS号 73-31-4
Inchi InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
InchiKey DRLFMBDRBRZALE-UHFFFAOYSA-N
分子式 Molecular Weight C13H16N2O2
分子量 Formula 232.28
溶解度Solubility DMF: 30 mg/ml DMSO: 30 mg/ml DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml Ethanol: 20 mg/ml
性状 Solid
储藏条件 Storage conditions 充氩保存；储存温度-20℃
N-乙酰-5-甲氧基色胺;N-乙酰基-5-甲氧基色胺;松果素;松果体素;3-N-乙酰基-5-甲氧基色胺;褪黑色素;褪黑激素;美拉托宁;退黑素(73-31-4)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净后，烘干消毒存放。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
产品说明 Melatonin, Endogenous hormone agonist at MT1 and MT2 receptors?褪黑激素是一种吲哚胺神经激素，其水平在每日周期中变化，从而可以夹带动物、植物和微生物中几种生物功能的昼夜节律。
IntroductionMelatonin, Endogenous hormone agonist at MT1 and MT2 receptors? is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several
Application1确定褪黑激素对缺氧缺血后新生大鼠神经细胞内质网应激和sirtuin 1表达的影响
Application2褪黑激素已被实验性动物摄入用于以下研究：· 确定长期的褪黑激素摄入是否能够诱导生殖变化以及褪黑激素如何在排卵期间发挥其与大鼠卵巢中脂质氧化和抗氧化活性相关的保护作用
Application3强大的抗氧化剂
Melatonin, also known as circadin or melatol, belongs to the class of organic compounds known as 3-alkylindoles. 3-alkylindoles are compounds containing an indole moiety that carries an alkyl chain at the 3-position. Melatonin is a drug which is used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. it has received fda orphan drug status as an oral medication for this use. a number of studies have shown that melatonin may be effective for treating sleep-wake cycle disturbances in children and adolescents with mental retardation, autism, and other central nervous system disorders. it appears to decrease the time to fall asleep in children with developmental disabilities, such as cerebral palsy, autism, and mental retardation. it may also improve secondary insomnia associated with various sleep-wake cycle disturbances. other possible uses for which there is some evidence for include: benzodiazepine withdrawal, cluster headache, delayed sleep phase syndrome (dsps), primary insomnia, jet lag, nicotine withdrawal, preoperative anxiety and sedation, prostate cancer, solid tumors (when combined with il-2 therapy in certain cancers), sunburn prevention (topical use), tardive dyskinesia, thrombocytopenia associated with cancer, chemotherapy and other disorders. . Melatonin exists as a solid and is considered to be practically insoluble (in water) and relatively neutral. Melatonin has been found throughout most human tissues, and has also been primarily detected in saliva, urine, blood, and cerebrospinal fluid. Within the cell, melatonin is primarily located in the cytoplasm. Melatonin participates in a number of enzymatic reactions. In particular, Melatonin and S-adenosylhomocysteine can be biosynthesized from N-acetylserotonin and S-adenosylmethionine; which is catalyzed by the enzyme acetylserotonin O-methyltransferase. In addition, Melatonin can be converted into 6-hydroxymelatonin through its interaction with the enzyme cytochrome P450 1A1. In humans, melatonin is involved in the tryptophan metabolism pathway. Melatonin is a potentially toxic compound.
Melatonin is a hormone produced by the pineal gland that has multiple effects including somnolence, and is believed to play a role in regulation of the sleep-wake cycle. Melatonin is available over-the-counter and is reported to have beneficial effects on wellbeing and sleep. Melatonin has not been implicated in causing serum enzyme elevations or clinically apparent liver injury.
警示图
危险性 warning
危险性警示 No data available
安全声明 H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害
安全防护 P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理
备注 实验过程中防止吸入、食入，做好安全防护
Analyte: melatonin; matrix: pharmaceutical preparation; procedure: thin-layer chromatography densitometry Costantini A, Paoli F; Farmaco 53: 443-7 (1998)
Analyte: melatonin; matrix: pharmaceutical preparation; procedure: first- and second-derivative ultraviolet spectrophotometry and spectrofluorimetry PMID:9656147
melatonin; matrix: blood (plasma); procedure: radioimmunoassay PMID:2071448 Le Bars D et al; Int J Rad Appl Instrum B 18(3): 357-62 (1991)
Melatonin premedication significantly decreased the doses of both propofol and thiopental required to induce anesthesia. PMID:17122221 Naguib M et al; Anesth Analg 103 (6): 1448-52 (2006)

The effects of melatonin premedication on propofol and thiopental induction dose-response curves: a prospective, randomized, double-blind study.Mohamed Naguib 1, Abdulhamid H Samarkandi, Mohamed A Moniem, Emad El-Din Mansour, Ahmad A Alshaer, Hasan A Al-Ayyaf, Awatif Fadin, Saleh W Alharby.,
Abstract
Background: The effect of melatonin on the intraoperative requirements for i.v.anesthetics has not been documented. We studied the effect of melatonin premedication on the propofol and thiopental dose-response curves for abolition of responses to verbal commands and eyelash stimulation.
Methods: This prospective, randomized, double-blind study included 200 adults with ASA physical status I. Patients received either 0.2 mg/kg melatonin or a placebo orally for premedication (n = 100 per group). Approximately 50 min later, subgroups of 10 melatonin and 10 placebo patients were administered various doses of propofol (0.5, 1.0, 1.5, 2.0, or 2.4 mg/kg) or thiopental (2.0, 3.0, 4.0, 5.0, or 6.0 mg/kg) for anesthetic induction. The ability of each patient to respond to the command, "open your eyes," and the disappearance of the eyelash reflex were assessed 60 s after the end of the injection of propofol or thiopental. Dose-response curves were determined by probit analysis.
Results: Melatonin premedication decreased thiopental ED50 values for loss of response to verbal command and eyelash reflex from 3.4 mg/kg (95% confidence interval, 3.2-3.5 mg/kg) and 3.7 mg/kg (3.5-3.9 mg/kg) to 2.7 mg/kg (2.6-2.9 mg/kg) and 2.6 mg/kg (2.5-2.7 mg/kg), respectively (P < 0.05). Corresponding propofol ED50 values decreased from 1.5 mg/kg (1.4-1.6 mg/kg) and 1.6 mg/kg (1.5-1.7 mg/kg) to 0.9 mg/kg (0.8-0.96 mg/kg) and 0.9 mg/kg (0.8-0.95 mg/kg), respectively (P < 0.05).
Conclusions: Melatonin premedication significantly decreased the doses of both propofol and thiopental required to induce anesthesia.

Melatonin premedication and the induction dose of propofol.Turkistani A, Abdullah KM, Al-Shaer AA, Mazen KF, Alkatheri K.Eur J Anaesthesiol. 2007 May;24(5):399-402. doi: 10.101

Abstract
Background and objectives: Melatonin (N-acetyl-5-methoxytryptamine) is the main indolamine secreted by the pineal gland. Many studies showed that premedication with melatonin is associated with preoperative anxiolysis and sedation without impairment of cognitive and psychomotor skills and without prolonging recovery. We hypothesized that melatonin decreases the amount of propofol required to produce an adequate depth of hypnosis at induction time.
Methods: After approval from the research committee of the anaesthesia department, informed written consent was taken from 45 adult patients undergoing different surgical procedures. They were allocated randomly into three groups according to the premedication. At 100 min preoperatively, premedication was given in the form of oral melatonin 3 mg (M3 group), oral melatonin 5 mg (M5 group) or no premedication (P group). After preoxygenation an anaesthesiologist who was blinded to the premedication injected propofol 10 mg over 5 s every 15 s until the bispectral index (BIS) score fell to 45. The total dose of propofol required to achieve a BIS score of 45 was recorded. Response to verbal commands and eyelash reflex was evaluated and correlated to the BIS score and propofol dosage. When a BIS score of 45 was reached, tracheal intubation was accomplished after administration of a narcotic and muscle relaxant.
Results: The mean (standard devitation (SD)) induction dose of propofol producing a BIS score of 45 was 134 (25) mg in the placebo group vs. 115 (19.5) and 114 (20.9) mg in the M3 and M5 groups, respectively (P < 0.05). The propofol dose required to achieve loss of eyelash reflex and loss of response to verbal commands was more in the placebo group. Anxiety score as assessed by visual analogue scale (VAS) scored more in the placebo group than both melatonin groups. Time spent in the recovery room did not differ between the three groups.
Conclusion: Melatonin premedication, in an oral dose of either 3 or 5 mg, reduced the required dose of propofol to achieve a BIS score of 45, reflecting a sufficient level of hypnosis for tracheal intubation without prolongation of postoperative recovery room stay.

    对不起，暂无产品评价！
MSDS
SDS 1.0 中文
展开
SDS 1.0 英文
展开
        新闻

        怎么做细胞爬片免疫组化染色实验

        细胞爬片免疫组化染色，是通过细胞爬片是让玻片浸在细胞培养基内，细胞在玻片上生长，主要用于组织学，免疫组织化学...

        2020/7/20 22:04:33

        提取病毒RNA的实验方法

        提取病毒RNA方法分别有：异硫氰酸胍的提取病毒RNA方法、TRIzol LS提取法、Trizol法提取法等等...

        2020/7/22 20:29:26

        细胞培养耗材技术领先性

        细胞培养板行业面临的核心痛点是：常规TC处理后表面亲水角随时间衰减，影响长期培养稳定性，BIOFOUNT高分...

        2026/4/28 15:12:51

        细胞培养耗材关键性能

        细胞培养板的水接触角作为表面润湿性的核心指标，直接影响细胞贴壁、增殖、分化及功能表达，其中40°（低接触角/...

        2026/4/28 14:52:44

        chelex 100树脂国产替代之路-BIOFOUNT范德生物

        Chelex 100螯合离子交换树脂对铜、铁和其他重金属?的偏好显著高于对钠、钾等一价阳离子的偏好。它对二价...

        2025/11/4 14:22:46

        9月开学季——助研新学期 范德送好礼

        2025/8/28 15:30:55

        Waxfilm 实验室封口膜：技术与国际市场的双重突破

        在实验室耗材领域，封口膜是保障实验准确性与稳定性的关键产品之一。近年来，Waxfilm?实验室封口膜凭借其卓...

        2025/5/13 13:03:40

        Waxfilm实验室封口膜的5大突破

        Waxfilm实验室封口膜作为生物功能膜领域的国产技术突破和品牌突破，是生物领域中国技术发展的缩影。

        2025/5/6 17:02:07

        各种微流控芯片键合方法的优缺点

        微流控芯片键合：目前主要有激光焊接、热压键合、胶键合、超音波焊接，每种方法都有各自的优缺点。本文主要介绍聚酯...

        2023/7/28 10:43:09

        新一代微流控键合解决方案

        微流控键合解决方案：微流控芯片制造的一个重要环节，也是最容易被忽视的--芯片键合。其中一个重要因素是：微流控...

        2023/7/27 12:44:28

        Copyright 2017 Biofount Beijing Bio-Tech Co.,LTD, All Rights by BIOFOUNT    备案号:京ICP备17040948号-1      生物试剂、化学试剂、抑制剂、缓冲液、标准品、研发用化合物
        在线咨询 电话咨询
        My title page contents