精胺|Spermine|71-44-3|MFCD00008215-范德生物科技公司

精胺

精胺
NMR and HPLC COA下载 MSDS下载
Names：
Spermine
CAS号：
71-44-3
MDL Number： MFCD00008215
MF(分子式)： C10H26N4 MW(分子量)： 202.34
EINECS:200-754-2 Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

精胺(71-44-3,Spermine)是一种十四烷基的聚氮杂链烷，其中1、5、10、14位的碳被氮取代。精胺对细胞代谢具有广泛的作用。精胺具有抗氧化剂，免疫抑制剂和基本代谢物的作用。精胺是一种聚氮杂链烷和四胺。精胺是亚精胺衍生的生物多胺，在所有pH值下均作为聚阳离子存在。精胺存在于各种组织和生物体中，经常在某些细菌物种中作为必需的生长因子。精胺与核酸有关，尤其是在病毒中，并被认为可以稳定螺旋结构。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
SS4110-5g	5g	≥ 97%	¥ 969.00	¥ 969.00		3-5days	- +	¥ 0.00
SS4110-1g	1g	≥ 97%	¥ 278.00	¥ 278.00		3-5days	- +	¥ 0.00

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中文别名	精胺(71-44-3,Spermine);精碱精素;肝胺;肌胺;精素;1,12-二氨基-4,9-二氮十二烷
英文别名	Spermine(71-44-3);musculamine;neuridine;gerontine;Spermin
CAS号	71-44-3
SMILES	C(CCNCCCN)CNCCCN
Inchi	InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InchiKey	PFNFFQXMRSDOHW-UHFFFAOYSA-N
分子式 Molecular Weight	C10H26N4
分子量 Formula	202.34
闪点 FP	175.6±22.6 °C
熔点 Melting point	28-30 °C
沸点 Boiling point	308.4±0.0 °C at 760 mmHg
Polarizability极化度	24.8±0.5 10-24cm3
密度 Density	0.9±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±0.6 mmHg at 25°C
溶解度Solubility	H2O : 125 mg/mL (617.77 mM; Need ultrasonic)
性状	白色至灰白色（<29°C固体，> 29°C液体）
储藏条件 Storage conditions	4°C，密封储存，远离潮湿和阳光

精胺(71-44-3,Spermine)的毒理属性测试：

生物	测试类型	路线	报告剂量（标准化剂量）	影响	参考
rat	LD50	intraperitoneal	33 mg/kg (33 mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES; KIDNEY, URETER, AND BLADDER: CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)	Toxicology and Applied Pharmacology., 88(433), 1987 [PMID:3576625]
rat	LD50	intravenous	65 mg/kg (65 mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD; BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY); LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives Internationales de Pharmacodynamie et de Therapie., 165(374), 1967 [PMID:6031471]
mouse	LDLo	intraperitoneal	8 mg/kg (8 mg/kg)		Toxicology and Applied Pharmacology., 23(288), 1972 [PMID:5074577]
mouse	LD50	intravenous	56 mg/kg (56 mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#00641
mouse	LD30	oral	650 mg/kg (650 mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY); BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Agents and Actions, A Swiss Journal of Pharmacology., 14(228), 1984 [PMID:6324559]

精胺(71-44-3,Spermine)实验注意事项：
1.使用71-44-3实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.使用71-44-3实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品71-44-3的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品71-44-3时尽量采用多个药勺分别使用，使用后清洗干净。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
大规格定制：定制产品请将信息发送至sales@bio-fount.com。

Spermine(71-44-3) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:精胺(71-44-3,Spermine),精胺试剂,精胺的纯度,精胺的作用,精胺的外观,精胺的生产厂家,精胺的溶解度,精胺的注意事项,精胺的MSDS,精胺的储存条件,精胺的熔点,精胺的价格,精胺的用途,精胺的分子式

产品说明	精胺(71-44-3,Spermine)是由亚精胺形成的生物多胺，几乎存在于所有组织中。71-44-3的熔点，71-44-3的其他参数见主页
Introduction	Spermine (71-44-3,精胺) is a biological polyamine formed by spermidine, which exists in almost all tissues. The melting point of 71-44-3 and other parameters of 71-44-3 can be found on the homepage
Application1	精胺对于赘生性和正常组织的生长都是必不可少的，并且参与钙依赖性免疫过程的调节。
Application2	精胺结合并激活NMDA，并且已经显示出以浓度依赖性方式增强NMDA诱导的电流。
Application3	精胺是GluR抑制剂。

精胺是衍生自亚精胺的内源性多胺。精胺可作为nNOS的抑制剂和NMDA谷氨酸受体的拮抗剂。

警示图
危险性
危险性警示	Not Available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理
备注	避免吸入，误食以及与皮肤接触

象形图
信号	Danger
GHS危险说明	Aggregated GHS information provided by 200 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H318 (77.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
防范说明代码	P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Spermine and oxacillin stress response on the cell wall synthesis and the global gene expression analysis in Methicillin-resistance Staphylococcus aureus(Genes & Genomics,2018)

Inhibition of Cation Channels in Human Erythrocytes by Spermine(The Journal of Membrane Biology,2010)

Spermine enhances IgM productivity of human-human hybridoma HB4C5 cells and human peripheral blood lymphocytes(Cytotechnology,1998)

External spermine prevents UVA-induced damage of Synechocystis sp. PCC 6803 via increased catalase activity and decreased H2O2 and malonaldehyde levels(Annals of Microbiology,2018)

Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion(Cancer Immunology, Immunotherapy,2006)

1.A novel role for antizyme inhibitor 2 as a regulator of serotonin and histamine biosynthesis and content in mouse mast cells.
Acosta-Andrade C1, Lambertos A2, Urdiales JL1, Sánchez-Jiménez F1, Peñafiel R2,3, Fajardo I4. Amino Acids. 2016 Apr 15. [Epub ahead of print]
Antizymes and antizyme inhibitors are key regulatory proteins of polyamine levels by affecting ornithine decarboxylase and polyamine uptake. Our previous studies indicated a metabolic interplay among polyamines, histamine and serotonin in mast cells, and demonstrated that polyamines are present in mast cell secretory granules, being important for histamine storage and serotonin levels. Recently, the novel antizyme inhibitor-2 (AZIN2) was proposed as a local regulator of polyamine biosynthesis in association with mast cell serotonin-containing granules. To gain insight into the role of AZIN2 in the biosynthesis and storage of serotonin and histamine, we have generated bone marrow derived mast cells (BMMCs) from both wild-type and transgenic Azin2 hypomorphic mice, and have analyzed polyamines, serotonin and histamine contents, and some elements of their metabolisms. Azin2 hypomorphic BMMCs did not show major mast cell phenotypic alterations as judged by morphology and specific mast cell proteases.

2.Structural Investigations of N-carbamoylputrescine Amidohydrolase from Medicago truncatula: Insights into the Ultimate Step of Putrescine Biosynthesis in Plants.
Sekula B1, Ruszkowski M2, Malinska M3, Dauter Z2. Front Plant Sci. 2016 Mar 30;7:350. doi: 10.3389/fpls.2016.00350. eCollection 2016.
Putrescine, 1,4-diaminobutane, is an intermediate in the biosynthesis of more complexed polyamines, spermidine and spermine. Unlike other eukaryotes, plants have evolved a multistep pathway for putrescine biosynthesis that utilizes arginine. In the final reaction, N-carbamoylputrescine is hydrolyzed to putrescine by N-carbamoylputrescine amidohydrolase (CPA, EC 3.5.1.53). During the hydrolysis, consecutive nucleophilic attacks on the substrate by Cys158 and water lead to formation of putrescine and two by-products, ammonia and carbon dioxide. CPA from the model legume plant, Medicago truncatula (MtCPA), was investigated in this work. Four crystal structures were determined: the wild-type MtCPA in complex with the reaction intermediate, N-(dihydroxymethyl)putrescine as well as with cadaverine, which is a longer analog of putrescine; and also structures of MtCPA-C158S mutant unliganded and with putrescine. MtCPA assembles into octamers, which resemble an incomplete left-handed helical twist.

3.Isoptericola cucumis sp. nov., isolated from the root tissue of cucumber (Cucumis sativus).
Kämpfer P1, Glaeser SP2, Kloepper JW3, Hu CH4, McInroy JA5, Martin K6, Busse HJ7. Int J Syst Evol Microbiol. 2016 Apr 5. doi: 10.1099/ijsem.0.001055. [Epub ahead of print]
A Gram-positive, aerobic organism, showing an irregular cell morphology was isolated from the root tissue of cucumber (Cucumis sativus) and investigated in detail for its taxonomic position. On the basis of the 16S rRNA gene sequence analysis strain AP-38T was shown to be most closely related to Isoptericola variablis (99.1%), and Isoptericola nanjingensis (98.9%). The 16S rRNA gene sequence similarity to all other Isoptericola species was ≤ 98.5 %. DNA-DNA similarities to Isoptericola variablis DSM 10177T and Isoptericola nanjingensis DSM 24300T were 31%/41% (reciprocal) and 34%/34% (reciprocal), respectively. The diagnostic diaminoacid of the peptidoglycan was L-lysine.The quinone system contained predominantly menaquinones MK-9(H4) and MK-9(H2). In the polar lipid profile major compounds were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylinositol and two phosphatidylinositol-mannosides. The polyamine pattern contained the major components spermidine and spermine and significant amounts of tyramine.

4.Quality Changes and Biogenic Amines Accumulation of Black Carp (Mylopharyngodon piceus) Fillets Stored at Different Temperatures.
Fan H1, Liu X1, Hong H1, Shen S1, Xu Q1, Feng L1, Luo Y2. J Food Prot. 2016 Apr;79(4):635-45. doi: 10.4315/0362-028X.JFP-15-373.
Postmortem quality changes of black carp (Mylopharyngodon piceus) fillets stored at 20, 4, and 0°C (in ice) were determined in terms of pH value, K value, total volatile basic nitrogen, free amino acids, biogenic amines, drip loss, electrical conductivity (EC), sensory score, and microbial growth. The results showed that black carp fillets could maintain a good quality for 2, 9, and 12 days when stored at 20, 4, and 0°C, respectively. Pseudomonads, Aeromonas, and Enterobacteriaceae were the main spoilage bacteria in black carp. Tryptamine, 2-phenylethylamine, putrescine, cadaverine, and tyramine increased significantly (P < 0.05) during storage at the three temperatures, but not spermidine and spermine, among which tyramine and putrescine were the main biogenic amines in black carp fillets. A significantly higher concentration of histamine (132.05 mg/kg on the third day) was detected in the samples stored at 20°C (P < 0.01) than at 4 and 0°C

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