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Reduced Glutathione
NMR and HPLC COA下载 MSDS下载 - Names：
Reduced Glutathione (GSH), Endogenous antioxidant
- CAS号：
70-18-8
MDL Number： MFCD00065939 - MF(分子式)： C10H17N3O6S MW(分子量)： 307.32
- EINECS:200-725-4 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
Reduced Glutathione (GSH), Endogenous antioxidant(70-18-8)是一种三肽，由大多数哺乳动物组织中存在的三个氨基酸（半胱氨酸，谷氨酸和甘氨酸）组成。谷胱甘肽起着抗氧化剂，自由基清除剂和解毒剂的作用。谷胱甘肽作为谷胱甘肽过氧化物酶的辅助因子，在氨基酸的摄取和白三烯的合成中也很重要。 作为谷胱甘肽S-转移酶的底物，谷胱甘肽与多种有害化学物质（如卤化物，环氧化物和自由基）反应，形成无害的惰性产物。 在红细胞中，这些反应通过减少高铁血红蛋白和过氧化物来防止氧化损伤。 谷胱甘肽还参与蛋白质中二硫键的形成和维持以及氨基酸跨细胞膜的运输。
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| SY0303-100g | 100g | 97% | ¥ 1234.00 | ¥ 1234.00 | 690 | Instock,1days | ¥ 0.00 | |
| SY0303-5g | 5g | 97% | ¥ 94.00 | ¥ 94.00 | 52 | Instock 1days | ¥ 0.00 | |
| SY0303-25g | 25g | 97% | ¥ 326.00 | ¥ 326.00 | 166 | Instock,1days | ¥ 0.00 |
| 中文别名 | Reduced Glutathione(70-18-8);谷胱甘肽;硫糠质;L-还原型谷胱甘肽;还原谷胱甘肽;5-L-谷氨酰-L-半胱氨酰甘氨酸;三缩氨基酸;麸氨基硫;谷胱甘肽还原型 |
| 英文别名 | Reduced Glutathione (GSH), Endogenous antioxidant(70-18-8);L-Glutathione;Glutathion;Isethion |
| CAS号 | 70-18-8 |
| Inchi | InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1 |
| InchiKey | RWSXRVCMGQZWBV-WDSKDSINSA-N |
| 分子式 Molecular Weight | C10H17N3O6S |
| 分子量 Formula | 307.32 |
| 溶解度Solubility | 溶于水、稀醇、液氨和甲基甲酰胺，而不溶于醇、醚和丙酮 |
| 性状 | 无色透明细长柱状晶体 |
| 储藏条件 Storage conditions | 储存温度2-8℃,充氩保存 |
谷胱甘肽(70-18-8,Glutathione)的毒性测试:
| 生物 | 测试类型 | 路线 | 报告剂量（标准化剂量） | 影响 | 参考 |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 5 gm/kg (5000 mg/kg) | Modern Pharmaceuticals of Japan, IV, Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972, -(93), 1972 | |
| mouse | LD50 | intraperitoneal | 4020 mg/kg (4020 mg/kg) | Modern Pharmaceuticals of Japan, IV, Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972, -(93), 1972 | |
| mouse | LD50 | subcutaneous | 5 gm/kg (5000 mg/kg) | Modern Pharmaceuticals of Japan, IV, Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972, -(93), 1972 | |
| mouse | LD50 | intravenous | 2238 mg/kg (2238 mg/kg) | Japanese Journal of Antibiotics., 38(137), 1985 [PMID:3157807] | |
| mouse | LD50 | intramuscular | 4 gm/kg (4000 mg/kg) | Modern Pharmaceuticals of Japan, III, Tokyo, Japan Pharmaceutical, Medical and Dental Suppl Exporters' Assoc., 1968, -(97), 1968 |
谷胱甘肽(70-18-8,Glutathione)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净后，烘干消毒存放。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
Glutathione(70-18-8) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:谷胱甘肽(70-18-8,Glutathione),谷胱甘肽试剂,谷胱甘肽的组成,谷胱甘肽的作用,谷胱甘肽的合成,谷胱甘肽的纯度,谷胱甘肽的使用,谷胱甘肽的生产,谷胱甘肽的MSDS,谷胱甘肽的COA,谷胱甘肽的外观,谷胱甘肽的溶解度
| 产品说明 | 谷胱甘肽(70-18-8)是一种内源性抗氧化剂,谷胱甘肽在减少细胞代谢和呼吸爆发过程中形成的活性氧中起主要作用.谷胱甘肽溶解度,谷胱甘肽msds详见主页. |
| Introduction | Glutathione (70-18-8,谷胱甘肽) is an endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and respiratory bursts. |
| Application1 | 谷胱甘肽有广谱的解毒作用，能与进入机体的有毒化合物如丙烯腈、氟化物、一氧化碳、重金属离子或致癌物质等相结合，并促进其排出体外。 |
| Application2 | 谷胱甘肽做为体内一种重要的抗氧化剂，能够清除掉人体内的自由基 |
| Application3 | 谷胱甘肽有抗过敏作用，能抑制乙酰胆碱、胆碱酯酶的失衡引起的过敏。 |
Glutathione may decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP. Glutathione can be used not only as medicine, but also as a base material for functional foods. It is widely used in functional foods such as delaying aging, enhancing immunity, and anti-tumor.
谷胱甘肽(70-18-8,Glutathione)的制备方法：
1.从酵母细胞中提取谷胱甘肽的工艺流程：
2.从小麦胚芽中提取谷胱甘肽的工艺流程：
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | No data available |
| 安全声明 | H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害 |
| 安全防护 | P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理 |
| 备注 | 实验过程中防止吸入、食入，做好安全防护 |
| Extracellular glutathione fermentation using engineered Saccharomyces cerevisiae expressing a novel glutathione exporter |
| In Vivo Regulation of Hepatic Glutathione Synthesis: Effects of Food Deprivation or Glutathione Depletion by Electrophilic Compounds |
| Dietary Modulation of the Glutathione Detoxification Pathway and the Potential for Altered Xenobiotic Metabolism |
| Statuses of food-derived glutathione in intestine, blood, and liver of rat |
| Glutathione in plants: biosynthesis and physiological role in environmental stress tolerance |
Glutathione plays an essential role in nitric oxide-mediated iron-deficiency signaling and iron-deficiency tolerance in Arabidopsis.
Shanmugam V;Wang YW;Tsednee M;Karunakaran K;Yeh KC Plant J. 2015 Nov;84(3):464-77. doi: 10.1111/tpj.13011.
Abstract:Iron (Fe) deficiency is a common agricultural problem that affects both the productivity and nutritional quality of plants. Thus, identifying the key factors involved in the tolerance of Fe deficiency is important. In the present study, the zir1 mutant, which is glutathione deficient, was found to be more sensitive to Fe deficiency than the wild type, and grew poorly in alkaline soil. Other glutathione-deficient mutants also showed various degrees of sensitivity to Fe-limited conditions. Interestingly, we found that the glutathione level was increased under Fe deficiency in the wild type. By contrast, blocking glutathione biosynthesis led to increased physiological sensitivity to Fe deficiency. On the other hand, overexpressing glutathione enhanced the tolerance to Fe deficiency. Under Fe-limited conditions, glutathione-deficient mutants, zir1, pad2 and cad2 accumulated lower levels of Fe than the wild type. The key genes involved in Fe uptake, including IRT1, FRO2 and FIT, are expressed at low levels in zir1; however, a split-root experiment suggested that the systemic signals that govern the expression of Fe uptake-related genes are still active in zir1. Furthermore, we found that zir1 had a lower accumulation of nitric oxide (NO) and NO reservoir S-nitrosoglutathione (GSNO).
Protective effect of aspartate and glutamate on cardiac mitochondrial function during myocardial infarction in experimental rats.
Sivakumar R;Anandh Babu PV;Shyamaladevi CS Chem Biol Interact. 2008 Nov 25;176(2-3):227-33. doi: 10.1016/j.cbi.2008.08.008. Epub 2008 Aug 22.
Abstract:The present study investigates the effect of aspartate and glutamate on mitochondrial function during myocardial infarction (MI) in wistar rats. Male albino wistar rats were pretreated with aspartate [100 mg(kgbody weight)(-1) day(-1)] or glutamate [100 mg(kg body weight)(-1) day(-1)] intraperitoneally for a period of 7 days. Following amino acid treatment, MI was induced in rats by subcutaneous injection of isoproterenol [200 mg(kg body weight)(-1) day(-1)] for 2 days at an interval of 24 h. Isoproterenol (ISO) induction resulting in significant (P<0.05) increase in the levels of cardiac mitochondrial lipid peroxidation with a decrease in reduced glutathione level. The activities of glutathione peroxidase and glutathione reductase were significantly (P<0.05) decreased by ISO. ISO-induction also caused significant (P<0.05) decrease in the activities of mitochondrial tricarboxylic acid cycle enzymes (malate dehydrogenase, isocitrate dehydrogenase, succinate dehydrogenase, alpha-ketoglutarate dehydrogenase) and respiratory chain enzymes (NADH dehydrogenase and cytochrome-c-oxidase). ISO significantly (P<0.05) reduced the cytochrome contents, ATP production, ADP/O ratio and oxidation of succinate in state 3/state 4 whereas significantly (P<0).
Buthionine sulfoximine diverts the melanogenesis pathway toward the production of more soluble and degradable pigments.
Galván I;Wakamatsu K;Alonso-Alvarez C;Solano F Bioorg Med Chem Lett. 2014 May 1;24(9):2150-4. doi: 10.1016/j.bmcl.2014.03.031. Epub 2014 Mar 21.
Abstract:Buthionine sulfoximine (BSO) is a specific inhibitor of γ-glutamylcysteine synthetase, thus blocking the synthesis of glutathione (GSH). It is known that this makes that BSO affects melanin synthesis because of the role of thiols in melanogenesis. However, BSO may also react with the intermediate oxidation products of melanogenesis, a possibility that has not been investigated from the initial steps of the pathway. We created in vitro conditions simulating eumelanogenesis (oxidation of L-DOPA in the absence of GSH) and pheomelanogenesis (oxidation of L-DOPA in the presence of GSH) under presence or absence of BSO. BSO made that eumelanogenesis results in pigments more soluble and less resistant to degradation by hydrogen peroxide than pigments obtained without BSO. A similar but less marked effect was observed for pheomelanogenesis only at subsaturating concentrations of GSH. These results suggest that BSO diverts the melanogenesis pathway toward the production of more soluble and degradable pigments.
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