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氨苄青霉素
NMR and HPLC COA下载 MSDS下载 - Names：
Ampicillin
- CAS号：
69-53-4
MDL Number： MFCD00005175 - MF(分子式)： C16H19N3O4S MW(分子量)： 349.4
- EINECS:200-709-7 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| SS0355-100g | 100g | 98% | ¥ 798.00 | ¥ 798.00 | Instock | ¥ 0.00 | ||
| SS0355-25g | 25g | 98% | ¥ 316.00 | ¥ 316.00 | Instock | ¥ 0.00 | ||
| SS0355-5g | 5g | 98% | ¥ 156.00 | ¥ 156.00 | Instock | ¥ 0.00 |
| 中文别名 | 氨苄青霉素,氨苄青霉素(69-53-4,Ampicillin);氨苄西林;无水氨苄西林;苯明西林;苄那消;赛米西林;沙维西林 |
| 英文别名 | Ampicillin(69-53-4);Aminobenzylpenicillin;Ampicillin acid;Amcill;D-(?)-ampicillin |
| CAS号 | 69-53-4 |
| Inchi | InChI=1S/C16H19N3O4S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23)/t9-,10-,11+,14-/m1/s1 |
| InchiKey | AVKUERGKIZMTKX-NJBDSQKTSA-N |
| 分子式 Molecular Weight | C16H19N3O4S |
| 分子量 Formula | 349.4 |
| 溶解度Solubility | 0.1 M NaOH : 25 mg/mL (71.55 mM; Need ultrasonic) H2O : 5 mg/mL (14.31 mM; Need ultrasonic) |
| 性状 | 白色至灰白色固体粉末 |
| 储藏条件 Storage conditions | 4°C，避光 |
氨苄青霉素(69-53-4,Ampicillin)的毒理属性测试：
| 生物 | 测试类型 | 路线 | 报告剂量（标准化剂量） | 影响 | 参考 |
|---|---|---|---|---|---|
| man | TDLo | oral | 400 mg/kg/4W-I (400 mg/kg) | BLOOD: AGRANULOCYTOSIS; BLOOD: OTHER CHANGES | Annals of Internal Medicine., 69(91), 1968 [PMID:5658368] |
| women | TDLo | oral | 160 mg/kg/4D-I (160 mg/kg) | BLOOD: AGRANULOCYTOSIS; BLOOD: THROMBOCYTOPENIA | Annals of Internal Medicine., 99(573), 1983 |
| rat | LDLo | oral | >5 gm/kg (5000 mg/kg) | British Medical Journal., 2(197), 1961 | |
| rat | LD50 | intraperitoneal | 4500 mg/kg (4500 mg/kg) | Toxicology and Applied Pharmacology., 18(185), 1971 [PMID:5542824] | |
| rat | LDLo | subcutaneous | >5 gm/kg (5000 mg/kg) | British Medical Journal., 2(197), 1961 |
氨苄青霉素(69-53-4,Ampicillin)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净后，烘干消毒存放。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
Ampicillin(69-53-4) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
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| 产品说明 | 氨苄青霉素(69-53-4,Ampicillin)仅做科学研究实验使用,氨苄青霉素的作用,氨苄青霉素的熔点等参数见主页 |
| Introduction | Ampicillin (69-53-4,氨苄青霉素) is only used as an intermediate in scientific research and chemical synthesis. See the homepage for the role of 69-53-4 and the melting point of 69-53-4. |
| Application1 | 氨苄青霉素的作用是直接干扰肽聚糖的生物合成，导致细菌的结构不稳定和死亡。 |
| Application2 | 氨苄青霉素的独特之处在于其抑制细菌细胞壁生物发生的能力。 |
| Application3 | 除了作为广泛的抗生素发挥作用外，氨苄青霉素还可以在多种分离介质中用作选择剂。 |
Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family and is roughly equivalent to its successor, amoxicillin in terms of spectrum and level of activity. It is useful for the treatment of a number of bacterial infections. It acts as an irreversible inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. It inhibits the third and final stage of bacterial cell wall synthesis in binary fission, which ultimately leads to cell lysis. It has received FDA approval for its mechanism of action.
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | No data available |
| 安全声明 | H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害 |
| 安全防护 | P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理 |
| 备注 | 实验过程中防止吸入、食入，做好安全防护 |
| 象形图 |   |
|---|---|
| 信号 | Danger |
| GHS危险说明 |
Aggregated GHS information provided by 310 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria by 1 of 310 companies. For more detailed information, please visit ECHA C&L website Of the 9 notification(s) provided by 309 of 310 companies with hazard statement code(s): H317 (99.35%): May cause an allergic skin reaction [Warning Sensitization, Skin] H334 (99.68%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
| 防范说明代码 |
P261, P272, P280, P285, P302+P352, P304+P341, P321, P333+P313, P342+P311, P363, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Fabrication of ampicillin/starch/polymer composite nanofibers with controlled drug release properties by electrospinning(Journal of Sol-Gel Science and Technology,2015) |
| The pharmacokinetics of ampicillin–sulbactam in anuric patients: dosing optimization for prophylaxis during cardiovascular surgery(International Journal of Clinical Pharmacy,2016) |
| Pharmacokinetics of ampicillin–sulbactam and the renal function-based optimization of dosing regimens for prophylaxis in patients undergoing cardiovascular surgery |
| Cu(II)-catalyzed degradation of ampicillin: effect of pH and dissolved oxygen(Environmental Science and Pollution Research,2017) |
| Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin and pivampicillin(European Journal of Clinical Pharmacology,1974_ |
Draft Genome Sequence of Vancomycin-Susceptible, Ampicillin-Intermediate Enterococcus faecium Strain D344RRF.
García-Solache M1, Rice LB2. Genome Announc. 2016 May 5;4(3). pii: e01720-15. doi: 10.1128/genomeA.01720-15.
Enterococcus faecium is an important nosocomial pathogen, causing a substantial health burden due to high resistance to antibiotics and its ability to colonize the gastrointestinal tract. Here, we present the draft genome of vancomycin-susceptible, ampicillin-intermediate strain D344RRF, a rifampicin/fusidic acid-resistant and commonly used laboratory strain, which is useful in studying the transfer of antibiotic resistance.
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