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盐酸金霉素
NMR and HPLC COA下载 MSDS下载 - Names：
Chlorotetracycline hydrochloride
- CAS号：
64-72-2
MDL Number： MFCD00082440 - MF(分子式)： C22H23ClN2O8·HCL MW(分子量)： 515.34
- EINECS:222-936-0 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
盐酸金霉素(64-72-2,Chlorotetracycline hydrochloride)是具有广谱抗菌和抗原生动物活性的四环素。 盐酸四环素具有抑菌作用，并通过与30S核糖体亚基结合来抑制细菌蛋白质的合成，从而防止氨基酸添加到正在生长的肽链上。 该四环素对多种革兰氏阳性和革兰氏阴性生物，螺旋体，立克次体，某些原生动物，支原体和衣原体生物都有活性。在内质网研究中，金霉素已被用作荧光染料来分析在细胞凋亡和其他过程中钙的变化。金霉素已被证明能阻止血小板分泌，并能影响H295R细胞中17β-雌二醇（E2）的合成。
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| SS0383-25g | 25g | USP | ¥ 486.00 | ¥ 486.00 | Instock | ¥ 0.00 | ||
| SS0383-5g | 5g | USP | ¥ 108.00 | ¥ 108.00 | Instock | ¥ 0.00 |
| 中文别名 | 盐酸金霉素(64-72-2,Chlorotetracycline hydrochloride);盐酸氯四环素;金霉素盐酸盐;氯四环素;盐酸金霉素(标准品);盐酸金雷素 |
| 英文别名 | Chlorotetracycline hydrochloride(CAS:64-72-2);Chlorotetracycline hydrochloride;Aureociclina;Isphamycin;Aureomycin hydrochloride |
| CAS号 | 64-72-2 |
| Inchi | InChI=1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7-,8-,15-,21-,22-;/m0./s1 |
| InchiKey | CBHYYLPALVVVEY-MRFRVZCGSA-N |
| 分子式 Molecular Weight | C22H23ClN2O8·HCL |
| 分子量 Formula | 515.34 |
| 溶解度Solubility | H2O : 6.66 mg/mL (12.92 mM; Need ultrasonic and warming) DMSO : < 1 mg/mL (insoluble or slightly soluble) |
| 性状 | 浅黄色至黄色固体粉末 |
| 储藏条件 Storage conditions | Store at -20° C |
盐酸金霉素(64-72-2,Chlorotetracycline hydrochloride)毒理属性测试：
| 生物 | 测试类型 | 路线 | 报告剂量（标准化剂量） | 影响 | 参考 |
|---|---|---|---|---|---|
| cat | LD | intravenous | > 50mg/kg (50mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING | Annals of the New York Academy of Sciences. Vol. 51, Pg. 182, 1948. |
| dog | LDLo | intravenous | 150mg/kg (150mg/kg) | KIDNEY, URETER, AND BLADDER: HEMATURIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: TREMOR |
Annals of the New York Academy of Sciences. Vol. 51, Pg. 254, 1948. |
| guinea pig | LD | subcutaneous | > 300mg/kg (300mg/kg) | Annals of the New York Academy of Sciences. Vol. 51, Pg. 182, 1948. | |
| guinea pig | LDLo | intravenous | 100mg/kg (100mg/kg) | Annals of the New York Academy of Sciences. Vol. 51, Pg. 182, 1948. | |
| mouse | LD50 | intraperitoneal | 197mg/kg (197mg/kg) | Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 278, 1970. | |
| mouse | LD50 | intravenous | 100mg/kg (100mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 95, 1964. | |
| mouse | LD50 | oral | 2314mg/kg (2314mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 95, 1964. | |
| mouse | LDLo | subcutaneous | 400mg/kg (400mg/kg) | Annals of the New York Academy of Sciences. Vol. 51, Pg. 182, 1948. | |
| rabbit | LD | intravenous | > 50mg/kg (50mg/kg) | Annals of the New York Academy of Sciences. Vol. 51, Pg. 182, 1948. | |
| rat | LD | oral | > 3gm/kg (3000mg/kg) | Annals of the New York Academy of Sciences. Vol. 51, Pg. 182, 1948. | |
| rat | LD50 | intraperitoneal | 335mg/kg (335mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Antibiotics Annual. Vol. 1, Pg. 63, 1953/1954. |
| rat | LD50 | intravenous | 100mg/kg (100mg/kg) | Bollettino Chimico Farmaceutico. Vol. 102, Pg. 660, 1963. |
盐酸金霉素(64-72-2,Chlorotetracycline hydrochloride)实验注意事项：
1.使用64-72-2实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.使用64-72-2实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品64-72-2的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品64-72-2时尽量采用多个药勺分别使用，使用后清洗干净。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
大规格定制：定制产品请将信息发送至sales@bio-fount.com。
Chlorotetracycline hydrochloride(CAS:64-72-2) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:盐酸金霉素(64-72-2,Chlorotetracycline hydrochloride),盐酸金霉素试剂,金霉素,金霉素盐酸盐,盐酸金霉素的外观,盐酸金霉素的纯度,盐酸金霉素的作用,盐酸金霉素的结构式,盐酸金霉素的生产厂家,盐酸金霉素的价格,盐酸金霉素的MSDS,盐酸金霉素的注意事项,盐酸金霉素的储存条件
| 产品说明 | 盐酸金霉素(64-72-2,Chlorotetracycline hydrochloride)是一种特殊而有效的钙离子载体抗生素。64-72-2其他参数见主页。 |
| Introduction | Chlorotetracycline hydrochloride (64-72-2,盐酸金霉素) is a special and effective calcium ionophore antibiotic. 64-72-2 See the homepage for other parameters. |
| Application1 | 盐酸金霉素已经显示能抑制氨酰基-tRNA与核糖体的结合。 |
| Application2 | 细胞渗透荧光探针，用于测量内质网Ca2+ 流量 |
| Application3 |
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | Not Available |
| 安全声明 | H315,H319,H335 |
| 安全防护 | P261,P305+P351+P338 |
| 备注 | 避免吸入，误食以及与皮肤接触 |
| 象形图 |  |
|---|---|
| 信号 | Warning |
| GHS危险说明 |
H315 (95.37%): Causes skin irritation [Warning Skin corrosion/irritation] H317 (50%): May cause an allergic skin reaction [Warning Sensitization, Skin] H319 (95.37%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (95.37%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| 防范说明代码 |
P261, P264, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Effect of microwave power on phase, morphology, and photocatalytic properties of BiOIO3 nanostructure(Journal of the Australian Ceramic Society,2018) |
| Disinfestation of diverse fungal pathogen spores on inert contaminated materials(European Journal of Plant Pathology,2019) |
| Wurmbach, P., et al. 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 2143-2147. PMID: 221915 |
| White, J.R. and Pearce, F.L. 1982. Biochemistry. 21: 6309-6312. PMID: 7150561 |
| Akunda, J.K., et al. 2001. Comp. Immunol. Microbiol. Infect. Dis. 24: 81-89. PMID: 11247048 |
1.Meta-analysis of the effects of laidlomycin propionate, fed alone or in combination with chlortetracycline, compared with monensin sodium, fed alone or in combination with tylosin, on growth performance, health, and carcass outcomes in finishing steers in North America.
Cernicchiaro N, Corbin M, Quinn M, Prouty F, Branine M, Renter DG. J Anim Sci. 2016 Apr;94(4):1662-76. doi: 10.2527/jas.2015-0086.
The objective of this research was to use data from multiple studies to comprehensively quantify the effects of feeding 1) laidlomycin propionate (LP), alone and/or in combination with chlortetracycline, compared with 2) monensin sodium (MS), alone and/or in combination with tylosin, at commercially approved dosages, on ADG, DMI, feed efficiency (FE), mortality, and carcass characteristics (HCW and liver abscesses). A secondary objective was to explore potential sources of heterogeneity among the comparative effectiveness studies. A systematic review of peer-reviewed literature and industry reports was used to identify studies that included direct comparisons of these treatments in finishing steers in North America. Random-effects meta-analysis models of performance, carcass, and health-related outcomes were fitted with extracted data, consisting of a total of 17 data sets comprising a total of 135 pens and 13,603 steers. Results showed that pens of steers fed LP had increased ADG (live and carcass adjusted), DMI, and HCW compared with those fed monensin ( < 0.
2.Dissipation kinetics of oxytetracycline, tetracycline, and chlortetracycline residues in soil.
Li Y1, Wang H2, Liu X3, Zhao G1, Sun Y4. Environ Sci Pollut Res Int. 2016 Apr 13. [Epub ahead of print]
The dissipation of different residual states of tetracycline antibiotics (TCs) including oxytetracycline (OTC), tetracycline (TC), and chlortetracycline (CTC) laboratory microcosm systems was investigated in this study. The residues were fractionated by stepwise extractions into aqueous state (KCl solution extracts), organic state (MeOH extracts), residual state I (citric acid-sodium citrate buffer and ethyl acetate extracts) and residual state II (acetonitrile-EDTA-McIlvaine buffer extracts) for accurate evaluation of TCs pollution. The antibiotics in the aqueous state were hardly detected, whereas the antibiotics in the organic state dissipated relatively fast (not detectable within 15 days after application) and followed simple first-order kinetics (SFOK) (R 2 from 0.929 to 0.990). While first-order double-exponential decay model (FODED) (R 2 from 0.840 to 0.999) and availability-adjusted first-order model (AAFO) (R 2 from 0.939 to 0.
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