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乙二胺四乙酸二钠
NMR and HPLC COA下载 MSDS下载 - Names：
EDTA二钠（EDTA disodium salt）
- CAS号：
6381-92-6
MDL Number： MFCD00150037 - MF(分子式)： C10H14N2Na2O8·2H2O MW(分子量)： 372.24
- EINECS:205-358-3 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
乙二胺四乙酸二钠(6381-92-6,EDTA disodium salt)简称为EDTA二钠,是一种螯合剂(CHELATING AGENTS)，乙二胺四乙酸二钠可以螯合多种多价阳离子。 乙二胺四乙酸二钠用于制药和食品添加剂。乙二胺四乙酸二钠注射液与钙以及许多二价和三价金属的阳离子形成螯合物。由于其对亲和力的钙，乙二胺四乙酸二钠将产生一个降低血清钙水平静脉内输注期间。在延长的时间内缓慢输注可能会引起循环外钙库的动员。乙二胺四乙酸二钠对心脏产生负面的正性肌力作用。 乙二胺四乙酸二钠同样与其他多价金属形成螯合物，并增加尿中镁，锌和其他微量元素的排泄量。它不会与钾形成螯合物，但可能会降低血清水平并增加钾的尿流失。
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| SS0008-250g | 250g | AR,98% | ¥ 45.00 | ¥ 45.00 | Instock | ¥ 0.00 | ||
| SS1435-500g | 500g | GR,99% | ¥ 76.00 | ¥ 76.00 | 2-3days | ¥ 0.00 | ||
| SS1435-100g | 100g | GR,99% | ¥ 32.00 | ¥ 32.00 | 2-3days | ¥ 0.00 | ||
| SS1434-100g | 100g | 99.99% | ¥ 253.00 | ¥ 253.00 | 2-3days | ¥ 0.00 | ||
| SS1434-25g | 25g | 99.99% | ¥ 89.00 | ¥ 89.00 | 2-3days | ¥ 0.00 | ||
| SS1433-50g | 50g | for chromatography, ≥99.0% | ¥ 299.00 | ¥ 299.00 | 2-3days | ¥ 0.00 | ||
| SS1433-10g | 10g | for chromatography, ≥99.0% | ¥ 201.00 | ¥ 201.00 | 2-3days | ¥ 0.00 | ||
| SS0008-2.5kg | 2.5kg | AR,98% | ¥ 261.00 | ¥ 261.00 | 2-3days | ¥ 0.00 | ||
| SS0008-500g | 500g | AR,98% | ¥ 60.00 | ¥ 60.00 | 2-3days | ¥ 0.00 | ||
| SS0008-100g | 100g | AR,98% | ¥ 29.00 | ¥ 29.00 | Instock | ¥ 0.00 |
| 中文别名 | 乙二胺四乙酸二钠(6381-92-6),EDTA二钠;EDTA二钠二水合物盐,乙二胺四乙酸二钠盐,乙二胺四乙酸二钠二水合物, |
| 英文别名 | EDTA disodium salt(CAS:6381-92-6);EDTA disodium salt dihydrate;Glycine, N,N‘-1,2-ethanediylbis[N-(carboxymethyl)-, disodium salt, dihydrate; EDTA; |
| CAS号 | 6381-92-6 |
| Inchi | InChI=1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2 |
| InchiKey | OVBJJZOQPCKUOR-UHFFFAOYSA-L |
| 分子式 Molecular Weight | C10H14N2Na2O8·2H2O |
| 分子量 Formula | 372.24 |
| 溶解度Solubility | 3? M NaOH: 100?mg/mL |
| 性状 | 白色粉末或晶体 |
| 储藏条件 Storage conditions | 2-8°C密封保存。 |
乙二胺四乙酸二钠(6381-92-6,EDTA disodium salt)毒理性质：
乙二胺四乙酸二钠(6381-92-6,EDTA disodium salt)(10 mg / mL)增加了雄性Sprague-Dawley大鼠的中性，碱性和酸性化合物的肠道吸收。螯合剂将（14）C- 甘露醇和（14）C- 菊粉的吸收率从<2％增加到7％-b 1％，将（14）CN-甲基癸ame的吸收率从2％-3％增加到11％ -15％，磺胺酸的吸收率从11％-14％增至26％-32％。与对照组相比，药物的血浆浓度增加了五到六倍。 当以1％（w / v）的还原型谷胱甘肽给药时，浓度为1％（w / v; 24 mM）的EDTA二钠增加了雄性Charles River大鼠小肠中乙酰唑胺的原位药物吸收。肠道吸收增加了1.5至2倍；但是，通过EDTA和谷胱甘肽治疗不会从胃吸收。研究人员认为，EDTA钠二钠通过镁和钙离子的螯合改变了肠上皮的水渗透性，从而分离了上皮细胞。
当以1％（w / v）的还原型谷胱甘肽给药时，浓度为1％（w / v; 24 mM）的EDTA二钠提高了雄性Charles River大鼠小肠中乙酰唑胺的原位药物吸收。肠道吸收增加了1.5至2倍；但是，通过EDTA和谷胱甘肽治疗不会从胃吸收。研究人员认为，EDTA钠二钠通过镁和钙离子的螯合作用改变了肠上皮的水渗透性，从而分离了上皮细胞。
乙二胺四乙酸二钠(6381-92-6,EDTA disodium salt)实验注意事项：
1.使用6381-92-6实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.使用6381-92-6实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品6381-92-6的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品6381-92-6时尽量采用多个药勺分别使用，使用后清洗干净。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
大规格定制：定制产品请将信息发送至sales@bio-fount.com。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
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| 产品说明 | 乙二胺四乙酸二钠(EDTA二钠,6381-92-6)是一种防腐剂,EDTA二钠也是螯合剂,稳定剂EDTA二钠溶解度,乙二胺四乙酸二钠MSDS,乙二胺四乙酸二钠结构式详见主页. |
| Introduction | 乙二胺四乙酸二钠(6381-92-6,EDTA disodium salt)It is a preservative, chelating agent, stabilizer, used in the treatment of animal feed and drinking water food production animals. |
| Application1 | 无水乙二胺四乙酸二钠盐已用于：制备TE缓冲液，作为抗凝剂，作为流体缓冲液成分， 可抑制需要二价阳离子才能具有活性的酶，例如金属蛋白酶。 |
| Application2 | 络合剂，钙、镁及其他金属试剂，金属掩蔽剂 |
| Application3 | 乙二胺四乙酸二钠是一种重要络合剂，用于络合金属离子和分离金属 |
乙二胺四乙酸二钠(6381-92-6,EDTA二钠)药理学：
※乙二胺四乙酸二钠(6381-92-6,EDTA disodium salt)是一种防腐剂，螯合剂，稳定剂，乙二胺四乙酸二钠被允许在进料中和饮用水的动物和/或用于食品生产的动物的治疗。乙二胺四乙酸二钠不应包含防腐剂，抗氧化剂或螯合剂。
※乙二胺四乙酸二钠(6381-92-6,EDTA disodium salt)被认为是分子生物学级的，适用于分子生物学应用。对其中核酸酶和蛋白酶的存在也进行了分析。无水乙二胺四乙酸二钠盐已用于：制备TE缓冲液，作为抗凝剂，作为流体缓冲液成分，
※乙二胺四乙酸二钠可抑制需要二价阳离子才能具有活性的酶，例如金属蛋白酶。一种螯合剂（CHELATING AGENTS），可以螯合多种多价阳离子。 它用于制药和食品添加剂。
※乙二胺四乙酸二钠注射液与钙以及许多二价和三价金属的阳离子形成螯合物。由于其对亲和力的钙，乙二胺四乙酸二钠将产生一个降低血清钙水平静脉内输注期间。在延长的时间内缓慢输注可能会引起循环外钙库的动员。乙二胺四乙酸二钠对心脏产生负面的正性肌力作用。 乙二胺四乙酸二钠同样与其他多价金属形成螯合物，并增加尿中镁，锌和其他微量元素的排泄量。它不会与钾形成螯合物，但可能会降低血清水平并增加钾的尿流失。
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | 注意：可能刺激眼睛，皮肤和呼吸道引起胃肠道损伤 |
| 安全声明 | H303,H401 |
| 安全防护 | P273,P312,P501 |
| 备注 | 避免吸入，误食以及与皮肤接触 |
乙二胺四乙酸二钠(6381-92-6,EDTA disodium salt)危害标识：
| 象形图 |  |
| 信号 | Warning |
| GHS危险说明 | Aggregated GHS information provided by 409 companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
| Reported as not meeting GHS hazard criteria by 92 of 409 companies. For more detailed information, please visit ECHA C&L website | |
| Of the 18 notification(s) provided by 317 of 409 companies with hazard statement code(s): | |
| H302 (59.62%): Harmful if swallowed [Warning Acute toxicity, oral] | |
| H312 (36.91%): Harmful in contact with skin [Warning Acute toxicity, dermal] | |
| H315 (44.16%): Causes skin irritation [Warning Skin corrosion/irritation] | |
| H319 (51.42%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] | |
| H332 (55.84%): Harmful if inhaled [Warning Acute toxicity, inhalation] | |
| H335 (43.22%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] | |
| H373 (21.45%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] | |
| H412 (36.59%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] | |
| Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. | |
| 防范说明代码 | P260, P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P314, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501 |
| (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Antimicrobial effect of combinations of EDTA-Tris and amikacin or neomycin on the microorganisms associated with otitis externa in dogs Veterinary Research Communications 1994 |
| Direct lead determination in wine by hydride generation-atomic absorption spectrometry Microchimica Acta 1989 |
| Immunohistochemical Analysis of Urothelial Carcinoma Tissues for Proliferation and Differentiation Markers Urothelial Carcinoma 2018 28889376 |
| Preservation of and DNA Extraction from Muscle Tissue Forensic DNA Typing Protocols 2016 27259730 Detoxification of gold surfaces by OH? treatment Gold Bulletin 2019 |
| Phenotyping of Light Response on JA-Defective Mutant in Rice Jasmonate in Plant Biology 2020 31734914 |
乙二胺四乙酸二钠(6381-92-6,EDTA disodium salt)参考文献：
1，酶消化法-一种用于罗氏沼虾胚胎冷冻分离研究的安全，快速的技术。
Pillai BR1, Mohanty J. Cryobiology. 2003 Dec;47(3):242-6.
A new, safe, and rapid technique for the individual separation of the embryos of giant freshwater prawn Macrobrachium rosenbergii de Man is described. Two protease enzymes, e.g., trypsin and collagenase were used. Embryos in the advanced stage of development (gray embryos with eyespot and heart beat) were selected for the study. Treatment with collagenase and trypsin at respective concentrations of 0.05 and 0.25% for 30 min resulted in 100% separation of 35-40 mg of embryonic mass (approximately 180 embryos). A chelating agent, EDTA (ethylenediaminetetraacetic acid disodium salt: dihydrate) at 400 mg l(-1) enhanced the activity of trypsin. Trypsin and collagenase, when used together, were found to act synergistically. The separated embryos revealed no morphological injury when observed under the microscope. Further, in vitro hatching of the separated embryos was successful indicating that the present technique is safe and effective in achieving individual separation of prawn embryos.
2.通过乙二胺四乙酸的肼解作用改善了非还原性O-聚糖的释放。
Kozak RP1, Royle L2, Gardner RA2, Bondt A3, Fernandes DL2, Wuhrer M4. Anal Biochem. 2014 May 15;453:29-37. doi: 10.1016/j.ab.2014.02.030. Epub 2014 Mar 5.
The study of protein O-glycosylation is receiving increasing attention in biological, medical, and biopharmaceutical research. Improved techniques are required to allow reproducible and quantitative analysis of O-glycans. An established approach for O-glycan analysis relies on their chemical release in high yield by hydrazinolysis, followed by fluorescent labeling at the reducing terminus and high-performance liquid chromatography (HPLC) profiling. However, an unwanted degradation known as "peeling" often compromises hydrazinolysis for O-glycan analysis. Here we addressed this problem using low-molarity solutions of ethylenediaminetetraacetic acid (EDTA) in hydrazine for O-glycan release. O-linked glycans from a range of different glycoproteins were analyzed, including bovine fetuin, bovine submaxillary gland mucin, and serum immunoglobulin A (IgA). The data for the O-glycans released by hydrazine with anhydrous EDTA or disodium salt dihydrate EDTA show high yields of the native O-glycans compared with the peeled product, resulting in a markedly increased robustness of the O-glycan profiling method.
3，使用浴嘧啶二磺酸二钠盐评估铜（II）还原分析以评估总抗氧化剂能力：CUPRAC-BCS分析。
Campos C1, Guzmán R, López-Fernández E, Casado A. Anal Biochem. 2009 Sep 1;392(1):37-44. doi: 10.1016/j.ab.2009.05.024. Epub 2009 May 21.
There is heightened interest in determining antioxidant status of individuals in experimental and clinical studies investigating progression of diseases or diverse aspects of oxidative stress, among others. The aim of this study was to evaluate the copper(II) reduction assay with bathocuproinedisulfonic acid disodium salt as chelating agent (the CUPRAC-BCS assay) for the total antioxidant capacity (TAC) assessment in human plasma and urine. Samples from 20 individuals were determined with four spectrophotometric assays-CUPRAC-BCS, ferric reducing ability of plasma (FRAP), trolox equivalent antioxidant capacity (TEAC), and 1,1-diphenyl-2-picrylhydrazyl assay (DPPH)-to compare these methods. CUPRAC-BCS was significantly correlated with FRAP and TEAC for plasma and urine samples (r>0.5, P<0.05 for all) and with DPPH for urine samples (r=0.925, P<0.001) but not with DPPH for plasma samples (r=0.366, P=0.112). However, the four methods do not agree given that lines of equality and regression were not matched up.
4.使用金属-乙二胺四乙酸络合物对新德里金属β-内酰胺酶-1和其他产生金属β-内酰胺酶的革兰氏阴性细菌进行双盘协同试验的评估。
Fujisaki M1, Sadamoto S, Hishinuma A. Microbiol Immunol. 2013 May;57(5):346-52. doi: 10.1111/1348-0421.12042.
New Delhi metallo-β-lactamase-1 (NDM-1), one of the metallo-β-lactamases (MBLs), has been identified from clinical isolates worldwide. Rapid detection of NDM-1 producers is necessary to prevent their dissemination. Seven types of EDTA complexes were evaluated as MBL inhibitors in double-disk synergy tests (DDSTs), resulting in detection of the first isolate of NDM-1-producing Escherichia coli (NDM-1 Dok01) in Japan. NDM-1 Dok01 was detected when EDTA magnesium disodium salt tetrahydrate (Mg-EDTA), EDTA calcium disodium salt dihydrate, EDTA cobalt disodium salt tetrahydrate and EDTA copper disodium salt tetrahydrate were used as MBL inhibitors. The sensitivity and specificity of DDSTs using Mg-EDTA for 75 MBL producers and 25 non-MBL producers were 96.0% and 100%, respectively. These findings indicate that the DDST method using Mg-EDTA can detect MBL-producing strains, including NDM-1 producers.
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