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利巴韦林三磷酸 NMR and HPLCCOA下载MSDS下载
- Names：Ribavirin-triphosphate
- CAS号： 63142-71-2MDL Number：
- MF(分子式)： C8H15N4O14P3 (free acid)MW(分子量)： 484.14 g/mol (free acid)
- EINECS:Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| HCQ000091-100mg | 100mg | ＞90% | ¥ 0.00 | ¥ 0.00 | Get quote | ¥ 0.00 | ||
| HCQ000091-10mg | 10mg | ＞90% | ¥ 0.00 | ¥ 0.00 | Instock | ¥ 0.00 | ||
| HCQ000091-5mg | 5mg | ＞90% | ¥ 0.00 | ¥ 0.00 | Instock | ¥ 0.00 | ||
| HCQ000091-1mg | 1mg | ＞90% | ¥ 4800.00 | ¥ 4800.00 | Instock | ¥ 0.00 |
| 中文别名 | 利巴韦林三磷酸钠盐,利巴韦林三磷酸(CAS:63142-71-2,MSDS,熔点,应用) |
| 英文别名 | Ribavirin triphosphate;63142-71-2;Ribavirin-triphosphate;Ribavirin-TP;Ribavirin 5'-triphosphate |
| CAS号 | 63142-71-2 |
| SMILES | NC(=O)c1ncn(n1)[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O |
| Inchi | InChI=1S/C8H15N4O14P3/c9-6(15)7-10-2-12(11-7)8-5(14)4(13)3(24-8)1-23-28(19,20)26-29(21,22)25-27(16,17)18/h2-5,8,13-14H,1H2,(H2,9,15)(H,19,20)(H,21,22)(H2,16,17,18)/t3-,4-,5-,8-/m1/s1 |
| InchiKey | MMJOCKKLRMRSEQ-AFCXAGJDSA-N |
| 分子式 Molecular Weight | C8H15N4O14P3 (free acid) |
| 分子量 Formula | 484.14 g/mol (free acid) |
| 闪点 FP | No data available |
| 熔点 Melting point | No data available |
| 沸点 Boiling point | No data available |
| Polarizability极化度 | |
| 密度 Density | No data available |
| 蒸汽压 Vapor Pressure | |
| 溶解度Solubility | soluble in water；极易溶于水 |
| 性状 | power;白色固体粉末 |
| 储藏条件 Storage conditions | store at -20 °C Short term exposure (up to 1 week cumulative) |
利巴韦林三磷酸（63142-71-2,英文名：Ribavirin-triphosphate）产品注意事项：该产品需在低温下存储，利巴韦林三磷酸易分解成为利巴韦林二磷酸盐产品。
| 产品说明 | 利巴韦林三磷酸(CAS:63142-71-2,英文名:Ribavirin-triphosphate)是利巴韦林的磷酸衍生物，相似物还有利巴韦林一磷酸;利巴韦林二磷酸系列潜在冠状病毒抑制剂，易分解. |
| Introduction | 利巴韦林的直接抗病毒活性：丙型肝炎病毒NS5B聚合酶将利巴韦林三磷酸结合到新生的RNA产品中 |
| Application1 | 利巴韦林三磷酸是抗病毒核苷类似物利巴韦林的生物活性代谢产物。 在细胞中，前药利巴韦林被三磷酸化并抑制病毒RNA聚合酶，从而干扰了新形成的RNA的合成。 |
| Application2 | |
| Application3 |
利巴韦林三磷酸，是利巴韦林的磷酸衍生物。
在细胞中，前药利巴韦林被三磷酸化，并在其中抑制病毒RNA聚合酶，干扰新形成的RNA的合成。
利巴韦林与其他抗病毒药物联合使用可治疗慢性丙型肝炎。
Ribavirin triphosphate is the biologically active metabolite of antiviral nucleoside analog ribavirin. In cells, the prodrug ribavirin gets triphosphorylated and in it inhibits viral RNA polymerases, interfering with the synthesis of newly formed RNA.
| 警示图 | |
| 危险性 | |
| 危险性警示 | Not available |
| 安全声明 | |
| 安全防护 | P280-P305+P351+P338-P310 |
| 备注 |
| Eriksson?et al.?(1977) Inhibition of influenza-virus ribonucleic-acid polymerase by ribavirin triphosphate.?Antimicrob. Agents Ch.?11 (6):946. |
| Wray?et al.?(1985) Effect of ribavirin triphosphate on primer generation and elongation during influenza-virus transcription invitro.?Antivir. Res.?5 (1):39. |
| Hosoya?et al.?(1993) Comparative inhibitory effects of various nucleoside and nonnucleoside analogs on replication of influenza-virus type-A and type-B in-vitro and inovo.?J. Infect. Dis.?168 (3):641. |
| Jarvis?et al.?(1998) Ribavirin uptake by human erythrocytes and the involvement of nitrobenzylthioinosine-sensitive (es)- nucleoside transporters.?Brit. J. Pharmacol.?123 (8):1587. |
| Hong?et al.?(1999) Direct antiviral activity of ribavirin: Hepatitis C virus NS5B polymerase incorporates ribavirin triphosphate into nascent RNA products.?Hepatology?30 (4):773 Part 2 Suppl. S. |
Kiso et al. (2010) T-705 (favipiravir) activity against lethal H5N1 influenza A viruses. Proc. Natl. Acad. Sci. USA. 107 (2):882.
Maag et al. (2001) Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. J. Biol. Chem. 276 (49):46094.
Lanford et al. (2001) Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes. J. Virol. 75 (17):8074.
Crotty et al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat. Med. 6 (12):1375.
Ulrich et al. (2000) Towards the engineering of an orthogonal protein kinase/nucleotide triphosphate pair. Tetrahedron 56 (48):9495.
Maag et al. (2001) Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. J. Biol. Chem. 276 (49):46094.
Lanford et al. (2001) Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes. J. Virol. 75 (17):8074.
Crotty et al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat. Med. 6 (12):1375.
Ulrich et al. (2000) Towards the engineering of an orthogonal protein kinase/nucleotide triphosphate pair. Tetrahedron 56 (48):9495.
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