购物车 
-
乳糖
NMR and HPLC COA下载 MSDS下载 - Names：
lactose
- CAS号：
63-42-3
MDL Number： MFCD00151251 - MF(分子式)： C12H22O11 MW(分子量)： 342.30
- EINECS:200-559-2 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
乳糖(Lactosum,anhydrous,63-42-3)是人和牛奶中的葡萄糖和半乳糖的二糖。
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| SS1737-25g | 25g | Ph Eur,NF,JP,USP | ¥ 481.50 | ¥ 481.50 | Instock | ¥ 0.00 | ||
| SS1737-5g | 5g | Ph Eur,NF,JP,USP | ¥ 107.00 | ¥ 107.00 | Instock | ¥ 0.00 | ||
| SS1489-500g | 500g | 98% | ¥ 120.00 | ¥ 120.00 | Instock | ¥ 0.00 | ||
| SS0012-250g | 250g | 98% | ¥ 80.00 | ¥ 80.00 | Instock | ¥ 0.00 |
| 中文别名 | 乳糖(63-42-3),D-乳糖; 乳糖,无水; 无水乳糖;乳糖(一水); 二氢吡啶酯; 一水合乳糖 |
| 英文别名 | Lactose(63-42-3),Anhydrous lactose,LACTOSE - ANHYDROUS,Lactose (anhydrous) |
| CAS号 | 63-42-3 |
| Inchi | InChI=1S/C12H22O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8-,9-,10+,11+,12-/m0/s1 |
| InchiKey | DKXNBNKWCZZMJT-JVCRWLNRSA-N |
| 分子式 Molecular Weight | C12H22O11 |
| 分子量 Formula | 342.30 |
| 溶解度Solubility | Freely but slowly soluble in water, practically insoluble in ethanol (96 per cent). |
| 性状 | Powder |
| 储藏条件 Storage conditions | Store at 4°C,-4℃下存储更优 |
乳糖(Lactosum , anhydrous,63-42-3)毒理性质：
乳糖(Lactosum , anhydrous,63-42-3)物理性质：
D-乳糖;β乳糖;无水乳糖;乳糖,无水;(63-42-3)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净后，烘干消毒存放。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:乳糖蒸汽压,乳糖合成,乳糖标准,乳糖应用,乳糖合成,乳糖沸点,乳糖闪点,乳糖用途,乳糖溶解度,乳糖价格,乳糖作用,乳糖结构式,乳糖用处
| 动物 | 测试类型 | 途径 | 实验摄入量 (标准摄入量) | 影响 | 文献来源 |
| dog | LDLo | intravenous | 1500mg/kg (1500mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
| rat | LD50 | intraperitoneal | > 10gm/kg (10000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975. | |
| rat | LD50 | oral | > 10gm/kg (10000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975. | |
| rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975. |
乳糖(Lactosum , anhydrous,63-42-3)物理性质：
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 201-202 | deg C | EXP | |
| log P (octanol-water) | -5.030 | (none) | EST | |
| Water Solubility | 1.95E+05 | mg/L | 20 | EXP |
| Vapor Pressure | 8.09E-17 | mm Hg | 25 | EST |
| Henry's Law Constant | 3.40E-19 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.54E-10 | cm3/molecule-sec | 25 | EST |
D-乳糖;β乳糖;无水乳糖;乳糖,无水;(63-42-3)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净后，烘干消毒存放。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:乳糖蒸汽压,乳糖合成,乳糖标准,乳糖应用,乳糖合成,乳糖沸点,乳糖闪点,乳糖用途,乳糖溶解度,乳糖价格,乳糖作用,乳糖结构式,乳糖用处
| 产品说明 | 乳糖(63-42-3)是人和牛奶中的葡萄糖和半乳糖的二糖.乳糖溶解度,乳糖MSDS,乳糖结构式,乳糖应用详见主页 |
| Introduction | Lactosum , anhydrous(63-42-3);Lactosum , anhydrous:(63-42-3) used for scientific research and chemical synthesis intermediates |
| Application1 | |
| Application2 | A disaccharide sugar present in milk. |
| Application3 |
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | No data available |
| 安全声明 | H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害 |
| 安全防护 | P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理 |
| 备注 | 实验过程中防止吸入、食入，做好安全防护 |
| The role of a mixture of DMSO?:?water in the crystallization of α-lactose monohydrate (α-LM) single crystals with desired morphology. K. Vinodhini, K. Srinivasan , CrystEngComm , 2015 , 17 , 6376 |
| Broadband terahertz time-domain spectroscopy of drugs-of-abuse and the use of principal component analysis. Andrew D. Burnett, Wenhui Fan, Prashanth C. Upadhya, John E. Cunningham, Michael D. Hargreav |
| Report of the Milk Products Sub-Committee to the Standing Committee on Uniformity of Analytical Methods. Milk products. Report No. 3. The analysis of sweetened condensed milk in which the sucrose has |
| Hydrogel/enzyme dots as adaptable tool for non-compartmentalized multi-enzymatic reactions in microfluidic devices. David Simon, Franziska Obst, Sebastian Haefner, Toni Heroldt, Martin Peiter, Frank S |
| One-step photostructuring of multiple hydrogel arrays for compartmentalized enzyme reactions in microfluidic devices. Franziska Obst, David Simon, Philipp J. Mehner, Jens W. Neubauer, Anthony Beck, Ol |
1.Determination of levothyroxine and its degradation products in pharmaceutical tablets by HPLC-UV-ICP-MS. Sasi S. Kannamkumarath, Rodolfo G. Wuilloud, Apryll Stalcup, Joseph A. Caruso, Himanshu Patel, Adel Sakr , J. Anal. At. Spectrom. , 2004 , 19 , 107
Abstract：A new analytical methodology using high-performance liquid chromatography (HPLC) coupled to inductively coupled plasma mass spectrometry (ICP-MS) was applied to study the presence of possible degradation products in levothyroxine tablets. The analytical methodology takes advantage of the element-specific and highly-sensitive I detection provided by ICP-MS and is applied to the speciation of: 3,3′,5,5′-tetraiodothyronine (T4); 3,3′,5-triiodothyronine (T3); 3,5-diiodothyronine (T2); 3,3′,5,5′-tetraiodothyroacetic acid (TTAA4); 3,3′,5-triiodothyroacetic acid (TTAA3); and 3,5-diiodothyroacetic acid (TTAA2). Chromatographic conditions were optimized by using UV absorption at 225 nm and ICP-MS detection of 127I. Complete chromatographic resolution of the levothyroxine degradation products within 25 min was obtained using 22% (v/v) acetonitrile at pH 2.3, adjusted with 0.08% (v/v) trifluoroacetic acid. The introduction of the mobile phase containing acetonitrile was performed by post column on-line dilution (1∶3.3) of the chromatographic eluent with a 2% (v/v) nitric acid solution using a PTFE tee. The separations with either detector were good with little detector effect on the resolution. The peak broadening caused by on-line dilution was insignificant. The detection limits obtained with UV detection ranged from 28.9 to 34.5 µg l−1, whereas those obtained with the plasma detector were about 175–375 times better (lower). Finally, the analytical methodology was applied to the determination of possible iodine species originated by degradation of T4 in synthetic and commercial levothyroxine sodium tablets.
2.Lactose malabsorption and intolerance: a review. Santiago Ugidos-Rodríguez, María Cruz Matallana-González, María Cortes Sánchez-Mata , Food Funct. , 2018 , 9 , 4056
Abstract：Food lactose and lactose intolerance are today hot topics in the field of food and nutrition. About 70% of the adult world population is lactose-intolerant, due to low levels of intestinal lactase, also called lactase-phlorizin hydrolase (LPH), a β-D-galactosidase found in the apical surface of the intestinal microvilli. This may be due to the loss of intestinal lactase in adulthood, a condition transmitted by an autosomal recessive gene, which differs in humans according to race. According to the cultural-historical hypothesis, the mutation that allows the metabolization of lactose appeared about 10?000 years ago in the inhabitants of Northern Europe where mammalian milk continued in the diet after weaning, and lactase-persistent populations were genetically selected in some areas. Many intolerant individuals can tolerate low levels of lactose in their daily diet. Probiotics have also been proposed as an alternative that could avoid some symptoms of lactose intolerance. Many products are marketed nowadays as alternatives to dairy products for lactose-intolerant individuals. However, the rules for low-lactose foods are currently not harmonised in the European Union. As scientific knowledge on lactose intolerance has notably advanced in recent decades, the aim of this work was to review the current state of the knowledge on lactose and lactose intolerance, its diagnosis and clinical management, and the various food products that are offered specifically for non-tolerant individuals.
3.Interactions of alkali- and alkaline earth-halides with carbohydrates in the crystalline state – the overlooked salt and sugar cocrystals. Heiko Oertling , CrystEngComm , 2016 , 18 , 1676
Abstract：Ionic cocrystals have recently gained attention as multi-component pharmaceutical materials capable of improving the physicochemical properties of the respective pharmaceutically active compound. Contrastingly, ionic cocrystals between common carbohydrates and alkali or alkaline earth halides have been investigated since the beginning of chemistry. This is well reflected in the multitude of denominations attached to this class of crystalline species over the years, e.g. adducts, binary compounds, complexes, cocrystals, ionic cocrystals or metal–organic frameworks. Throughout several centuries, these compounds have been inspected with the specific perspective of contemporary interest. In most cases, they can conveniently be prepared from the ionic salt and the respective neutral carbohydrate via solution crystallization or mechanochemical approaches and therefore offer an opportunity for fundamental studies in the fields of crystal engineering and solid state chemistry, bridging traditional organic and inorganic chemistry. Certainly ionic cocrystals remain an underexplored class of compounds and this review gives an in-depth overview of the work that has been performed until today, hoping to elicit further contributions in the discipline.
Abstract：A new analytical methodology using high-performance liquid chromatography (HPLC) coupled to inductively coupled plasma mass spectrometry (ICP-MS) was applied to study the presence of possible degradation products in levothyroxine tablets. The analytical methodology takes advantage of the element-specific and highly-sensitive I detection provided by ICP-MS and is applied to the speciation of: 3,3′,5,5′-tetraiodothyronine (T4); 3,3′,5-triiodothyronine (T3); 3,5-diiodothyronine (T2); 3,3′,5,5′-tetraiodothyroacetic acid (TTAA4); 3,3′,5-triiodothyroacetic acid (TTAA3); and 3,5-diiodothyroacetic acid (TTAA2). Chromatographic conditions were optimized by using UV absorption at 225 nm and ICP-MS detection of 127I. Complete chromatographic resolution of the levothyroxine degradation products within 25 min was obtained using 22% (v/v) acetonitrile at pH 2.3, adjusted with 0.08% (v/v) trifluoroacetic acid. The introduction of the mobile phase containing acetonitrile was performed by post column on-line dilution (1∶3.3) of the chromatographic eluent with a 2% (v/v) nitric acid solution using a PTFE tee. The separations with either detector were good with little detector effect on the resolution. The peak broadening caused by on-line dilution was insignificant. The detection limits obtained with UV detection ranged from 28.9 to 34.5 µg l−1, whereas those obtained with the plasma detector were about 175–375 times better (lower). Finally, the analytical methodology was applied to the determination of possible iodine species originated by degradation of T4 in synthetic and commercial levothyroxine sodium tablets.
2.Lactose malabsorption and intolerance: a review. Santiago Ugidos-Rodríguez, María Cruz Matallana-González, María Cortes Sánchez-Mata , Food Funct. , 2018 , 9 , 4056
Abstract：Food lactose and lactose intolerance are today hot topics in the field of food and nutrition. About 70% of the adult world population is lactose-intolerant, due to low levels of intestinal lactase, also called lactase-phlorizin hydrolase (LPH), a β-D-galactosidase found in the apical surface of the intestinal microvilli. This may be due to the loss of intestinal lactase in adulthood, a condition transmitted by an autosomal recessive gene, which differs in humans according to race. According to the cultural-historical hypothesis, the mutation that allows the metabolization of lactose appeared about 10?000 years ago in the inhabitants of Northern Europe where mammalian milk continued in the diet after weaning, and lactase-persistent populations were genetically selected in some areas. Many intolerant individuals can tolerate low levels of lactose in their daily diet. Probiotics have also been proposed as an alternative that could avoid some symptoms of lactose intolerance. Many products are marketed nowadays as alternatives to dairy products for lactose-intolerant individuals. However, the rules for low-lactose foods are currently not harmonised in the European Union. As scientific knowledge on lactose intolerance has notably advanced in recent decades, the aim of this work was to review the current state of the knowledge on lactose and lactose intolerance, its diagnosis and clinical management, and the various food products that are offered specifically for non-tolerant individuals.
3.Interactions of alkali- and alkaline earth-halides with carbohydrates in the crystalline state – the overlooked salt and sugar cocrystals. Heiko Oertling , CrystEngComm , 2016 , 18 , 1676
Abstract：Ionic cocrystals have recently gained attention as multi-component pharmaceutical materials capable of improving the physicochemical properties of the respective pharmaceutically active compound. Contrastingly, ionic cocrystals between common carbohydrates and alkali or alkaline earth halides have been investigated since the beginning of chemistry. This is well reflected in the multitude of denominations attached to this class of crystalline species over the years, e.g. adducts, binary compounds, complexes, cocrystals, ionic cocrystals or metal–organic frameworks. Throughout several centuries, these compounds have been inspected with the specific perspective of contemporary interest. In most cases, they can conveniently be prepared from the ionic salt and the respective neutral carbohydrate via solution crystallization or mechanochemical approaches and therefore offer an opportunity for fundamental studies in the fields of crystal engineering and solid state chemistry, bridging traditional organic and inorganic chemistry. Certainly ionic cocrystals remain an underexplored class of compounds and this review gives an in-depth overview of the work that has been performed until today, hoping to elicit further contributions in the discipline.
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