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醋酸甲地孕酮
NMR and HPLC COA下载 MSDS下载 - Names：
Megestrol Acetate
- CAS号：
595-33-5
MDL Number： No data available - MF(分子式)： C24H32O4 MW(分子量)： 384.52
- EINECS:209-864-5 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
醋酸甲地孕酮(595-33-5,Megestrol Acetate)是具有IC的合成孕激素50260μM抑制HegG2。目标：孕酮受体乙酸孕酮，也称为17α-乙酰氧基-6-脱氢-6-甲基孕酮，有时缩写为MGA或MA，是甾体孕激素和孕酮衍生物（特别是17-羟基化孕酮），主要具有孕激素和孕激素。促性腺激素作用。醋酸甲地孕酮是肌肉消瘦治疗的良好候选者，应针对药物和人体骨骼肌蛋白质更新之间的相互作用进行进一步的研究。
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| YZM000652-1g | 1g | 99.81% | ¥ 506.00 | ¥ 506.00 | 2-3天 | ¥ 0.00 | ||
| YZM001228-500mg | 500mg | 99.81% | ¥ 387.00 | ¥ 387.00 | In-stock | ¥ 0.00 | ||
| YZM000652-500mg | 500mg | 99.81% | ¥ 390.00 | ¥ 390.00 | 2-3天 | ¥ 0.00 |
| 中文别名 | 醋酸甲地孕酮(595-33-5);甲地孕酮醋酸酯;醋酸酯;孕甾酮;载脂蛋白;博雷亚;林美孕酮;林-美孕酮;林美孕酮;玛加斯;梅加斯;梅格弗伦;梅格斯塔;醋酸孕甾酮;17α-乙酰氧基-6-甲基孕甾-4,6-二烯-3,20-二酮;6-甲基-17Α-羟基孕甾-4,6-二烯-3,20-二酮醋酸酯;6-甲基-17alpha-羟基孕甾-4,6-二烯-3,20-二酮醋酸酯;甲地孕酮乙酸酯;17α-Acetoxy-6-methyl-4,6-pregnadiene-3,20-dione;6-亚甲基醋酸孕酮;甲地孕酮.17-乙酸酯(595-33-5) |
| 英文别名 | Megestrol Acetate(595-33-5);Acetate, Megestrol;Apo Megestrol;Apo-Megestrol;ApoMegestrol;Borea;Lin Megestrol;Lin-Megestrol;LinMegestrol;Maygace;Megace;Megefren;Megestat;Megestrol Acetate;Megostat;Mestrel;Nu Megestrol;Nu-Megestrol;NuMegestrol; |
| CAS号 | 595-33-5 |
| Inchi | InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1 |
| InchiKey | RQZAXGRLVPAYTJ-GQFGMJRRSA-N |
| 分子式 Molecular Weight | C24H32O4 |
| 分子量 Formula | 384.52 |
| 溶解度Solubility | 几乎不溶于水，溶于丙酮，微溶于乙醇、乙醚。 |
| 性状 | 白色或微黄色结晶性粉末（甲醇） |
| 储藏条件 Storage conditions | 冰箱Store at 4°C,-4℃下存储更优 |
醋酸甲地孕酮(595-33-5,Megestrol Acetate)毒理性质：
醋酸甲孕甾酮口服混悬剂的剂量高达1200 mg / day的研究未引起严重的意外副作用。用乙酸孕甾酮（一种致孕剂）治疗也导致了医源性肾上腺抑制。推测该机理与乙酸孕甾酮的糖皮质激素特性有关。
| 生物 | 测试类型 | 路线 | 剂量 | 影响 | 参考 |
| mouse | LD50 | intravenous | 56 mg/kg (56 mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#00931 |
醋酸甲地孕酮(595-33-5,Megestrol Acetate)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净后，烘干消毒存放。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
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| 产品说明 | 醋酸甲地孕酮(595-33-5,Megestrol Acetate)是一种合成的孕激素制剂，抑制HepG2的IC50为260μM。 |
| Introduction | 醋酸甲地孕酮(595-33-5,Megestrol Acetate)It is a synthetic progestin preparation with an IC50 of 260μM to inhibit HepG2. |
| Application1 | |
| Application2 | |
| Application3 |
醋酸甲地孕酮(595-33-5,Megestrol Acetate)药理学：
醋酸甲地孕酮(595-33-5,Megestrol Acetate)是具有IC的合成孕激素50260μM抑制HegG2。目标：孕酮受体乙酸孕酮，也称为17α-乙酰氧基-6-脱氢-6-甲基孕酮，有时缩写为MGA或MA，是甾体孕激素和孕酮衍生物（特别是17-羟基化孕酮），主要具有孕激素和孕激素。促性腺激素作用。醋酸甲地孕酮是肌肉消瘦治疗的良好候选者，应针对药物和人体骨骼肌蛋白质更新之间的相互作用进行进一步的研究。
醋酸甲地孕酮是乙酸盐形式甲地孕酮，天然存在的雌性激素的合成衍生物孕酮与潜在的抗雌激素和抗肿瘤活性。模仿孕酮的作用，醋酸甲地孕酮结合并激活生殖系统中的核孕酮受体，并使配体-受体复合物易位至细胞核，并与靶基因结合并促进其表达。这导致蛋白质合成的改变，从而调节生殖组织的细胞生长。由于孕酮，孕酮的负反馈机制此外，它还能阻止从垂体释放黄体生成激素（LH），从而导致排卵受到抑制，宫颈粘液和子宫内膜发生改变。此外，在不刺激LH的情况下，停止从卵巢释放雌激素，因此阻碍了对雌激素敏感的肿瘤细胞的生长。 醋酸孕孕激素是一种具有作用的孕激素，其用途与一般的孕激素相似。它还具有抗雄激素特性。在姑息治疗中可以通过口服给予，也可以作为子宫内膜癌和乳腺癌中其他治疗的辅助药物。醋酸孕甾酮已被批准用于治疗厌食症和恶病质。
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | No data available |
| 安全声明 | H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害 |
| 安全防护 | P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理 |
| 备注 | 实验过程中防止吸入、食入，做好安全防护 |
醋酸甲地孕酮(595-33-5,Megestrol Acetate)危害标识：
| 象形图 |  |
| 信号 | Danger |
| GHS危险说明 | Aggregated GHS information provided by 123 companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
| H302 (14.63%): Harmful if swallowed [Warning Acute toxicity, oral] | |
| H312 (13.82%): Harmful in contact with skin [Warning Acute toxicity, dermal] | |
| H332 (13.82%): Harmful if inhaled [Warning Acute toxicity, inhalation] | |
| H341 (26.02%): Suspected of causing genetic defects [Warning Germ cell mutagenicity] | |
| H350 (24.39%): May cause cancer [Danger Carcinogenicity] | |
| H351 (74.8%): Suspected of causing cancer [Warning Carcinogenicity] | |
| H360 (62.6%): May damage fertility or the unborn child [Danger Reproductive toxicity] | |
| H362 (23.58%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation] | |
| H373 (34.96%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] | |
| Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. | |
| 防范说明代码 | P201, P202, P260, P261, P263, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P314, P322, P330, P363, P405, and P501 |
| (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Neumann, F., The physiological action of progesterone and the pharmacological effects of progestogens--a short review. Postgrad Med J, 1978. 54 Suppl 2: p. 11-24. |
| Argiles, J.M., A. Anguera, and B. Stemmler, A new look at an old drug for the treatment of cancer cachexia: megestrol acetate. Clin Nutr, 2013. 32(3): p. 319-24. |
醋酸甲地孕酮(595-33-5,Megestrol Acetate)参考文献：
1. Dronabinol在治疗与HIV和AIDS相关的减肥中的临床用途。
Badowski ME1, Perez SE2. HIV AIDS (Auckl). 2016 Feb 10;8:37-45. doi: 10.2147/HIV.S81420. eCollection 2016.
Since the beginning of the HIV/AIDS epidemic, weight loss has been a common complaint for patients. The use of various definitions defining HIV wasting syndrome has made it difficult to determine its actual prevalence. Despite the use of highly active antiretroviral therapy, it is estimated that the prevalence of HIV wasting syndrome is between 14% and 38%. HIV wasting syndrome may stem from conditions affecting chewing, swallowing, or gastrointestinal motility, neurologic disease affecting food intake or the perception of hunger or ability to eat, psychiatric illness, food insecurity generated from psychosocial or economic concerns, or anorexia due to medications, malabsorption, infections, or tumors. Treatment of HIV wasting syndrome may be managed with appetite stimulants (megestrol acetate or dronabinol), anabolic agents (testosterone, testosterone analogs, or recombinant human growth hormone), or, rarely, cytokine production modulators (thalidomide).
2.乙酸孕甾酮的眼科制剂在猫嗜酸性粒细胞性角膜炎的治疗中的用途。
Stiles J1, Coster M2. Vet Ophthalmol. 2016 Mar 3. doi: 10.1111/vop.12371. [Epub ahead of print]
OBJECTIVE: To evaluate a compounded ophthalmic formulation of 0.5% megestrol acetate to treat eosinophilic keratitis in cats.
3.用于子宫内膜癌的氟维司群。
Battista MJ1, Schmidt M1. Expert Opin Investig Drugs. 2016 Apr;25(4):475-83. doi: 10.1517/13543784.2016.1154532. Epub 2016 Mar 8.
INTRODUCTION: About one third of patients with endometrial cancer (EC) relapse and face a limited prognosis, if surgery or radiotherapy are not feasible. The remaining therapeutic options are chemotherapy and endocrine therapy.
4.无法手术的子宫内膜癌的临床治疗。
Palisoul M1, Mutch DG1. Expert Rev Anticancer Ther. 2016 Apr 7:1-7. [Epub ahead of print]
Unresectable endometrial cancer, while rare, has a very poor prognosis, with a survival rate of 2 to 8 months. Although endometrial cancer is generally regarded as a survivable disease, the less common advanced and aggressive forms account for a large portion of endometrial cancer related deaths. Given the paucity of inoperable disease, randomized clinical data is lacking in this specific patient population. Management decisions regarding radiation therapy or systemic therapy are largely guided by the existing data in the setting of recurrence or second-line treatment, adjuvant therapy following optimal debulking, or in patients who are considered inoperable due to medical comorbidities rather than the extent of their disease.
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