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L-谷氨酰胺
NMR and HPLC COA下载 MSDS下载 - Names：
L-Glutamine
- CAS号：
56-85-9
MDL Number： MFCD00008044 - MF(分子式)： C5H10N2O3 MW(分子量)： 146.15
- EINECS:200-292-1 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
L-谷氨酰胺(56-85-9,L-Glutamine)是人体中大量存在的非必需氨基酸，并参与许多代谢过程。L-谷氨酰胺是标准遗传密码编码的20个氨基酸之一。L-谷氨酰胺是L-谷氨酰胺的共轭碱。L-谷氨酰胺是L-谷氨酸的共轭酸。L-谷氨酰胺是D-谷氨酰胺的对映异构体。L-谷氨酰胺是L-谷氨酰胺两性离子的互变异构体。
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| HCM75471-100mg | 100mg | 95% | ¥ 0.00 | ¥ 0.00 | Get quote | ¥ 0.00 | ||
| SY0082-100g | 100g | 99% | ¥ 92.00 | ¥ 92.00 | Instock | ¥ 0.00 | ||
| SY0082-25g | 25g | 99% | ¥ 52.00 | ¥ 52.00 | Instock | ¥ 0.00 |
| 中文别名 | L-谷氨酰胺(56-85-9,L-Glutamine);L-麸氨酰胺;L-氨羰基丁氨酸;左谷酰胺;L-谷胺酰胺;L-谷氨酸-5-酰胺;L-2-氨基戊二酸酰胺;L-(+)-谷氨酰胺/2-氨基戊二酸;(S)-2,5-二氨基-5-氧代戊酸 |
| 英文别名 | L-Glutamine(56-85-9);glutamine;Levoglutamide;L-(+)-Glutamine;Glutamic acid amide;Stimulina |
| CAS号 | 56-85-9 |
| Inchi | InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 |
| InchiKey | ZDXPYRJPNDTMRX-VKHMYHEASA-N |
| 分子式 Molecular Weight | C5H10N2O3 |
| 分子量 Formula | 146.15 |
| 溶解度Solubility | Soluble in water (35 mg/ml at 20 °C), DMSO (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). Insoluble in methanol, and ether. |
| 性状 | 白色至灰白色固体粉末 |
| 储藏条件 Storage conditions | 室温保存 |
L-谷氨酰胺(56-85-9,L-Glutamine)毒理属性测试：
| 生物 | 测试类型 | 路线 | 报告剂量（标准化剂量） | 影响 | 参考 |
|---|---|---|---|---|---|
| man | TDLo | oral | 27 mg/kg/1W-I (27 mg/kg) | BEHAVIORAL: EUPHORIA | American Journal of Psychiatry., 141(1302), 1984 |
| rat | LD50 | oral | 7500 mg/kg (7500 mg/kg) | Drugs in Japan, 6(228), 1982 | |
| mouse | LD50 | oral | 21700 mg/kg (21700 mg/kg) | Drugs in Japan, 6(228), 1982 |
L-谷氨酰胺(56-85-9,L-Glutamine)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净后，烘干消毒存放。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
L-Glutamine(56-85-9) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:L-谷氨酰胺(56-85-9,L-Glutamine),L-谷氨酰胺试剂,L-谷氨酰胺的纯度,L-谷氨酰胺的作用,L-谷氨酰胺的外观,L-谷氨酰胺的储存条件,L-谷氨酰胺的结构式,L-谷氨酰胺的价格,L-谷氨酰胺的生产厂家,L-谷氨酰胺的合成路线,L-谷氨酰胺的MSDS
| 产品说明 | L-谷氨酰胺(56-85-9,L-Glutamine)仅做科学研究以及化学合成中间体使用,56-85-9其他参数见主页 |
| Introduction | L-Glutamine (56-85-9, L-Glutamine) is only used for scientific research and chemical synthesis intermediates. See the homepage for other parameters of 56-85-9 |
| Application1 | 生化研究，细菌培养基 |
| Application2 | |
| Application3 |
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | No data available |
| 安全声明 | H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害 |
| 安全防护 | P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理 |
| 备注 | 实验过程中防止吸入、食入，做好安全防护 |
| Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine(Scientific Reports,2016) |
| Endogenous glutamine production in critically ill patients: the effect of exogenous glutamine supplementation(Critical Care,2014) |
| Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts(Journal of Animal Science and Biotechnology,2012) |
| Dynamics of growth and metabolism controlled by glutamine availability in Chinese hamster ovary cells(Applied Microbiology and Biotechnology,2013) |
| Glutamine regulates amino acid transport and glutathione levels in a human neuroblastoma cell line(Pediatric Surgery International,2004) |
1.Protective effects of l-glutamine against toxicity of deltamethrin in the cerebral tissue.
Varol S1, Özdemir HH1, Çevik MU1, Altun Y1, Ibilo?lu I1, Ekinci A1, Ibilo?lu AO1, Balduz M1, Arslan D1, Tekin R1, Aktar F1, Aluçlu MU1. Neuropsychiatr Dis Treat. 2016 Apr 21;12:1005-11. doi: 10.2147/NDT.S104011. eCollection 2016.
BACKGROUND: Deltamethrin (DLM) is a broad-spectrum synthetic dibromo-pyrethroid pesticide that is widely used for agricultural and veterinary purposes. However, human exposure to the pesticide leads to neurotoxicity. Glutamine is one of the principal, free intracellular amino acids and may also be an antioxidant. This study was undertaken in order to examine the neuroprotective and antioxidant potential of l-glutamine against DLM toxicity in female Wistar albino rats.
2.Elevated basal glutamate and unchanged glutamine and gaba in refractory epilepsy.
Çavu? I1,2, Romanyshyn JC2, Kennard JT2, Farooque P3, Williamson A2, Eid T2,4, Spencer SS3, Duckrow R3, Dziura J5, Spencer DD2. Ann Neurol. 2016 Apr 30. doi: 10.1002/ana.24673. [Epub ahead of print]
OBJECTIVE: Aberrant glutamate and γ-aminobutyric acid (GABA) neurotransmission contribute to seizure generation and the epileptic state. However, whether levels of these neurochemicals are abnormal in epileptic patients is unknown. Here, we report interictal levels of glutamate, glutamine and GABA in epilepsy patients at seizure onset and non-epileptic sites, cortical lesions, and from patients with poorly localized neocortical epilepsies.
3.TXNIP Suppresses Expression of Glutamine Synthetase by Inducing Oxidative Stress in Retinal Muller Glia Under Diabetic Conditions.
Zhou J1, Shen X2, Lu Q1, Zhang M1. Med Sci Monit. 2016 May 1;22:1460-6.
BACKGROUND Diabetic retinopathy (DR) is a progressive neurodegenerative disease with early-stage symptoms such as dysfunction of Muller cells, which leads to ganglion cell death. Its pathogenesis is probably associated with oxidative stress and a recently discovered protein, thioredoxin-interacting protein (TXNIP). MATERIAL AND METHODS To explore the role of TXNIP in DR, we cultured Muller cells under diabetic conditions, and then used immunohistochemistry, Western blot, and RT-PCR to detect the expression level of TXNIP under diabetic conditions. We demonstrated the expression level of glutamine synthetase (GS) when TXNIP was inhibited. To explore the potential pathway of TXNIP-induced cell damage in DR, we confirmed the role of IL-1β under diabetic conditions. RESULTS Diabetes induces TXNIP expressions at mRNA levels, but shows the opposite effect on GS. IL-1β plays an important role in this pathway. Azaserine effectively increased the expression of GS via attenuating the expression of TXNIP.
4.RhoC is a Potent Regulator of Glutamine Metabolism and N-acetylaspartate Production in Inflammatory Breast Cancer Cells.
Wynn ML1, Yates JA1, Evans CR1, Van Wassenhove L2, Wu ZF1, Bridges S1, Bao L1, Fournier C1, Ashrafzadeh S1, Merrins MJ3, Satin LS1, Schnell S1, Burant CF1, Merajver SD4. J Biol Chem. 2016 Apr 25. pii: jbc.M115.703959. [Epub ahead of print]
Inflammatory breast cancer (IBC) is an extremely lethal cancer that rapidly metastasizes. While the molecular attributes of IBC have been described, little is known about the underlying metabolic features of the disease. Using a variety of metabolic assays including 13C tracer experiments, we found that SUM149 cells, the primary in vitro model of IBC, exhibit metabolic abnormalities that distinguish them from other breast cancer cells, including elevated levels of N-acetylaspartate (NAA), a metabolite primarily associated with neuronal disorders and gliomas. Here we provide the first evidence of NAA in breast cancer. We also report that the oncogene RhoC, a driver of metastatic potential, modulates glutamine and N-acetylaspartate metabolism in IBC cells in vitro, revealing a novel role for RhoC as a regulator of tumor cell metabolism that extends beyond its well-known role in cytoskeletal rearrangement.
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