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L-天门冬氨酸
NMR and HPLC COA下载 MSDS下载 - Names:
L-Aspartic acid
- CAS号:
56-84-8
MDL Number: MFCD00002616 - MF(分子式): C4H7NO4 MW(分子量): 133.10
- EINECS:200-291-6 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| CCF11483-100G | 100G | 待确认;手性纯度≥99%o.p. | ¥ 95.00 | ¥ 95.00 | 1-3days | ¥ 0.00 | ||
| HCM74450-1g | 1g | 95% | ¥ 0.00 | ¥ 0.00 | Get quote | ¥ 0.00 | ||
| SS1225-500g | 500g | 99% | ¥ 216.00 | ¥ 216.00 | Instock | ¥ 0.00 | ||
| SS1225-100g | 100g | 99% | ¥ 56.00 | ¥ 56.00 | Instock | ¥ 0.00 | ||
| SS1225-25g | 25g | 99% | ¥ 32.00 | ¥ 32.00 | Instock | ¥ 0.00 |
| 中文别名 | L-天门冬氨酸(56-84-8,L-Aspartic acid);L-天冬氨酸D-2-氨基丁酸;(S)-(+)-氨基琥珀酸;(S)-氨基丁二酸 |
| 英文别名 | L-Aspartic acid(56-84-8);aspartic acid;H-Asp-OH;L-aspartate;Asparagic acid |
| CAS号 | 56-84-8 |
| Inchi | InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1 |
| InchiKey | CKLJMWTZIZZHCS-REOHCLBHSA-N |
| 分子式 Molecular Weight | C4H7NO4 |
| 分子量 Formula | 133.10 |
| 溶解度Solubility | H2O : 8.33 mg/mL (62.58 mM; Need ultrasonic) |
| 性状 | 白色至灰白色固体粉末 |
| 储藏条件 Storage conditions | 4°C条件下存储,-4摄氏度存储更佳 |
L-天门冬氨酸(56-84-8,L-Aspartic acid)毒理属性测试:
| 生物 | 测试类型 | 路线 | 报告剂量(标准化剂量) | 影响 | 参考 |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 6 gm/kg (6000 mg/kg) | Pharmaceutical Chemistry Journal, 25(569), 1991 |
L-天门冬氨酸(56-84-8,L-Aspartic acid)实验注意事项:
1.实验前需戴好防护眼镜,穿戴防护服和口罩,佩戴手套,避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生,必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换,必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸,并无风处取药和称量以免扬撒,试剂的容器使用前务必确保干净,并消毒。
5.取药品时尽量采用多个药勺分别使用,使用后清洗干净后,烘干消毒存放。
6.实验后产生的废弃物需分类存储,并交于专业生物废气物处理公司处理,以免造成环境污染。
L-Aspartic acid(56-84-8) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:L-天门冬氨酸(56-84-8,L-Aspartic acid),L-天门冬氨酸的作用,L-天门冬氨酸的纯度,L-天门冬氨酸的外观,L-天门冬氨酸的生产厂家,L-天门冬氨酸的来源,L-天门冬氨酸的储存条件,L-天门冬氨酸的价格,L-天门冬氨酸的用途,L-天门冬氨酸的注意事项
| 产品说明 | L-天门冬氨酸(56-84-8,L-Aspartic acid)仅做科学研究以及化学合成中间体使用,56-84-8的熔点,56-84-8的外观等参数见主页 |
| Introduction | L-Aspartic acid(56-84-8,L-天门冬氨酸) is only used for scientific research and chemical synthesis intermediates. The melting point of 56-84-8 and the appearance of 56-84-8 are available on the homepage. |
| Application1 | 主要的神经递质,使快速突触兴奋 |
| Application2 | 是一种氨基酸,被证明是一种结肠特异性药物输送的前体药物。 |
| Application3 | L-天门冬氨酸是20种蛋白氨基酸之一。 |
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | No data available |
| 安全声明 | H319 |
| 安全防护 | P305+P351+P338 |
| 备注 | 实验过程中防止吸入、食入,做好安全防护 |
| How the extra methylene group affects the ligation properties of Glu vs. Asp and Gln vs. Asn amino acids: a DFT/PCM study(Journal of Molecular Modeling,2017) |
| TG study on the kinetics of the polymerization of aspartic acid catalyzed by sodium bisulfate(Journal of Thermal Analysis and Calorimetry,2003) |
| Redox potentials of dopamine and its supramolecular complex with aspartic acid(Russian Journal of Physical Chemistry A,2014) |
| Immunological Response to L-Asparaginase Loaded into Red Blood Cells(The Use of Resealed Erythrocytes as Carriers and Bioreactors,1992) |
| Dynamic changes in specific anti-L-asparaginase antibodies generation during acute lymphoblastic leukemia treatment(Pharmacological Reports,2018) |
1.Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses.
Zhao X;Sehgal M;Hou Z;Cheng J;Shu S;Wu S;Guo F;Le Marchand SJ;Lin H;Chang J;Guo JT J Virol. 2018 Feb 26;92(6). pii: e01535-17. doi: 10.1128/JVI.01535-17. Print 2018 Mar 15.
Interferon-induced transmembrane proteins (IFITMs) are restriction factors that inhibit the infectious entry of many enveloped RNA viruses. However, we demonstrated previously that human IFITM2 and IFITM3 are essential host factors facilitating the entry of human coronavirus (HCoV) OC43. In a continuing effort to decipher the molecular mechanism underlying IFITM differential modulation of HCoV entry, we investigated the roles of structural motifs important for IFITM protein posttranslational modifications, intracellular trafficking, and oligomerization in modulating the entry of five HCoVs. We found that three distinct mutations in IFITM1 or IFITM3 converted the host restriction factors to enhance entry driven by the spike proteins of severe acute respiratory syndrome coronavirus (SARS-CoV) and/or Middle East respiratory syndrome coronavirus (MERS-CoV). First, replacement of IFITM3 tyrosine 20 with either alanine or aspartic acid to mimic unphosphorylated or phosphorylated IFITM3 reduced its activity to inhibit the entry of HCoV-NL63 and -229E but enhanced the entry of SARS-CoV and MERS-CoV. Second, replacement of IFITM3 tyrosine 99 with either alanine or aspartic acid reduced its activity to inhibit the entry of HCoV-NL63 and SARS-CoV but promoted the entry of MERS-CoV.
2.Short exposure to low concentrations of alcohol during embryonic development has only subtle and strain- dependent effect on the levels of five amino acid neurotransmitters in zebrafish.
Mahabir S;Chatterjee D;Gerlai R Neurotoxicol Teratol. 2018 Jul - Aug;68:91-96. doi: 10.1016/j.ntt.2018.05.005. Epub 2018 Jun 7.
The zebrafish has been successfully employed to model and study the effects of embryonic alcohol exposure. Short exposure to low alcohol concentrations during embryonic development has been shown to significantly disrupt social behavior as well as the dopaminergic and serotoninergic systems in zebrafish. However, analysis of potential effects of embryonic alcohol exposure on other amino acid neurotransmitter systems has not been performed. Here we analyzed neurochemicals obtained from adult AB and TU strain zebrafish that were immersed in 0.00% (control), 0.25%, 0.50%, 0.75% or 1.00% alcohol solution (vol/vol%) at 24?h post-fertilization for 2?h. From whole brain extracts, we quantified glutamate, aspartate, glycine, taurine and GABA levels using high performance liquid chromatography (HPLC). We found embryonic alcohol exposure not to have any significant effect on the levels of glutamate, aspartate, glycine and GABA in both AB and TU zebrafish. AB zebrafish showed a significant elevation of taurine levels, but only in the highest alcohol dose group compared to control. These results, albeit mainly negative, together with prior findings suggest that behavioral abnormalities resulting from embryonic alcohol exposure described before for AB zebrafish may primarily be due to altered dopaminergic and serotoninergic mechanisms.
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