购物车 
-
二环己基碳二亚胺
NMR and HPLC COA下载 MSDS下载 - Names：
N,N′-Dicyclohexylcarbodiimide
- CAS号：
538-75-0
MDL Number： MFCD00011659 - MF(分子式)： C13H22N2 MW(分子量)： 206.33
- EINECS:208-704-1 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
二环己基碳二亚胺(N,N′-Dicyclohexylcarbodiimide,538-75-0)是一种白色结晶固体，带有强烈的甜味。二环己基碳二亚胺是在两个氮原子上具有环己基取代基的碳二亚胺化合物。 它具有肽偶联剂，ATP合酶抑制剂和交联剂的作用。
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| JH0667-500g | 500g | 99% | ¥ 486.00 | ¥ 486.00 | 3-5days | ¥ 0.00 | ||
| JH0667-100g | 100g | 99% | ¥ 162.00 | ¥ 162.00 | 3-5days | ¥ 0.00 | ||
| JH0667-25g | 25g | 99% | ¥ 72.00 | ¥ 72.00 | 3-5days | ¥ 0.00 |
| 中文别名 | 二环己基碳二亚胺(538-75-0);二环己基碳二亚胺; N,N’-二环己基碳二亚胺; N,N’-二环己基碳酰亚胺; N,N’-甲基四基双环己胺; 双环己基碳酰亚胺; N,N'-二环己基碳二亚胺; N,N'-二环己基碳酰亚胺; 1,3-二环己基碳二亚胺; N,Nˊ-二环己基碳二亚胺; N,Nˊ-二环己基碳酰亚胺; N,N`-二环己基碳化二亚胺; 二环己基碳化二亚胺; N‘N二环已基碳二亚胺; N' N-二环已基二亚胺; 1,3-二環己碳二醯亞胺; 二環己碳二亞胺; 碳二環己[醯]亞胺 |
| 英文别名 | N,N′-Dicyclohexylcarbodiimide(CAS:538-75-0);DICYCLOHEXYLCARBODIIMIDE; N,N'-Dicyclohexylcarbodiimide; DCCD; 1,3-Dicyclohexylcarbodiimide; DCCI; n,n-dicyclohexylcarbodiimide; Carbodicyclohexylimide; Bis(cyclohexyl)carbodiimide |
| CAS号 | 538-75-0 |
| Inchi | InChI=1S/C13H22N2/c1-3-7-12(8-4-1)14-11-15-13-9-5-2-6-10-13/h12-13H,1-10H2 |
| InchiKey | QOSSAOTZNIDXMA-UHFFFAOYSA-N |
| 分子式 Molecular Weight | C13H22N2 |
| 分子量 Formula | 206.33 |
| 溶解度Solubility | Soluble in methanol, chloroform, dichloromethane (100 mg/ml), and most organic solvents. Insoluble in water. |
| 性状 | Crystalline mass |
| 储藏条件 Storage conditions | 充氩保存 |
二环己基碳二亚胺(N,N′-Dicyclohexylcarbodiimide,538-75-0)毒理性质：
N,N'-二环己基碳二亚胺(DCC)实验注意事项：
1.使用538-75-0实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品538-75-0的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品538-75-0时尽量采用多个药勺分别使用，使用后清洗干净。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
大规格定制：定制产品请将信息发送至sales@bio-fount.com。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:二环己基碳二亚胺蒸汽压,二环己基碳二亚胺合成,二环己基碳二亚胺标准,二环己基碳二亚胺应用,二环己基碳二亚胺合成,二环己基碳二亚胺沸点,二环己基碳二亚胺闪点,二环己基碳二亚胺用途,二环己基碳二亚胺溶解度,二环己基碳二亚胺价格,二环己基碳二亚胺作用,二环己基碳二亚胺结构式,二环己基碳二亚胺用处
| 动物 | 测试类型 | 途径 | 实验摄入量 (标准摄入量) | 影响 | 文献来源 |
| rat | LD50 | oral | 400 mg/kg (400 mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS; GASTROINTESTINAL: HYPERMOTILITY, DIARRHEA; SKIN AND APPENDAGES (SKIN): HAIR: OTHER | National Technical Information Service., OTS0555962 |
| rat | LC50 | inhalation | 159 mg/m3/6H (159 mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE; VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION; SKIN AND APPENDAGES (SKIN): HAIR: OTHER | National Technical Information Service., OTS0555962 |
| rat | LD50 | intraperitoneal | 10 mg/kg (10 mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD; LUNGS, THORAX, OR RESPIRATION: DYSPNEA; LUNGS, THORAX, OR RESPIRATION: CYANOSIS | National Technical Information Service., OTS0555962 |
| mouse | LD50 | oral | >800 mg/kg (800 mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS; SKIN AND APPENDAGES (SKIN): HAIR: OTHER | National Technical Information Service., OTS0555962 |
| mouse | LD50 | intraperitoneal | >800 mg/kg (800 mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS; SKIN AND APPENDAGES (SKIN): HAIR: OTHER | National Technical Information Service., OTS0555962 |
| guinea pig | LD50 | skin | 10 mL/kg (10 mg/kg) | National Technical Information Service., OTS0555962 |
N,N'-二环己基碳二亚胺(DCC)实验注意事项：
1.使用538-75-0实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品538-75-0的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品538-75-0时尽量采用多个药勺分别使用，使用后清洗干净。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
大规格定制：定制产品请将信息发送至sales@bio-fount.com。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:二环己基碳二亚胺蒸汽压,二环己基碳二亚胺合成,二环己基碳二亚胺标准,二环己基碳二亚胺应用,二环己基碳二亚胺合成,二环己基碳二亚胺沸点,二环己基碳二亚胺闪点,二环己基碳二亚胺用途,二环己基碳二亚胺溶解度,二环己基碳二亚胺价格,二环己基碳二亚胺作用,二环己基碳二亚胺结构式,二环己基碳二亚胺用处
| 产品说明 | 二环己基碳二亚胺(538-75-0)是在两个氮原子上具有环己基取代基的碳二亚胺化合物,二环己基碳二亚胺溶解度,二环己基碳二亚胺MSDS详见主页. |
| Introduction | N,N′-Dicyclohexylcarbodiimide(二环己基碳二亚胺,538-75-0) is a carbodiimide compound having a cyclohexyl substituent on both nitrogen atoms. |
| Application1 | 溶于苯、乙醇、乙醚等大多数有机溶剂，不溶于水，和水反应，对潮湿敏感，皮肤接触可引起过敏，二氯甲烷溶解度 |
| Application2 | 脱氢偶联试剂，修饰小牛心线粒体脱氢转移酶；抑制F1F0-ATPase和其它的质子转移酶 |
| Application3 | 多肽合成试剂 |
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | Not Available |
| 安全声明 | H226,H312,H315,H317,H318 |
| 安全防护 | P280,P305+P351+P338 |
| 备注 | 避免吸入，误食以及与皮肤接触 |
| DCCD induced sodium uptake by Anacystis nidulans Archives of Microbiology 1977 |
| Electrogenesis in Plasma Membrane Fraction of Halotolerant Microalga Dunaliella maritima and Effects of N,N′-Dicyclohexylcarbodiimide Biochemistry (Moscow) 2020 |
| Effect of Dicyclohexylcarbodiimide (DCCD) on Transport Parameters in the Frog Cornea Epithelium The Journal of Membrane Biology |
| A clarification of the effects of DCCD on the electron transfer and antimycin binding of the mitochondrialbc\\n1 complex Journal of Bioenergetics and Biomembranes 1985 |
| Inhibition by dicyclohexylcarbodiimide of ATP synthesis in isolated rat hepatocytes Bioscience Reports 1984 |
1.Dissolved inorganic carbon uptake in Thiomicrospira crunogena XCL-2 is Δp- and ATP-sensitive and enhances RubisCO-mediated carbon fixation/PMID 26581415; Archives of microbiology 2016 Mar; 198(2):149-59/Name matches: ATP dccd
Abstract：The gammaproteobacterium Thiomicrospira crunogena XCL-2 is an aerobic sulfur-oxidizing hydrothermal vent chemolithoautotroph that has a CO2 concentrating mechanism (CCM), which generates intracellular dissolved inorganic carbon (DIC) concentrations much higher than extracellular, thereby providing substrate for carbon fixation at sufficient rate. This CCM presumably requires at least one active DIC transporter to generate the elevated intracellular concentrations of DIC measured in this organism. In this study, the half-saturation constant (K CO2) for purified carboxysomal RubisCO was measured (276 ± 18 µM) which was much greater than the K CO2 of whole cells (1.03 µM), highlighting the degree to which the CCM facilitates CO2 fixation under low CO2 conditions. To clarify the bioenergetics powering active DIC uptake, cells were incubated in the presence of inhibitors targeting ATP synthesis (DCCD) or proton potential (CCCP). Incubations with each of these inhibitors resulted in diminished intracellular ATP, DIC, and fixed carbon, despite an absence of an inhibitory effect on proton potential in the DCCD-incubated cells. Electron transport complexes NADH dehydrogenase and the bc 1 complex were found to be insensitive to DCCD, suggesting that ATP synthase was the primary target of DCCD. Given the correlation of DIC uptake to the intracellular ATP concentration, the ABC transporter genes were targeted by qRT-PCR, but were not upregulated under low-DIC conditions. As the T. crunogena genome does not include orthologs of any genes encoding known DIC uptake systems, these data suggest that a novel, yet to be identified, ATP- and proton potential-dependent DIC transporter is active in this bacterium. This transporter serves to facilitate growth by T. crunogena and other Thiomicrospiras in the many habitats where they are found.
2.ATP hydrolysis by membrane-bound Escherichia coli F0F1 causes rotation of the gamma subunit relative to the beta subunits/PMID 8688454; Biochimica et biophysica acta 1996 Jul; 1275(1-2):96-100 (Review Article)/Name matches: ATP dccd
Abstract：We recently demonstrated that the gamma subunit in soluble F1-ATPase from Escherichia coli rotates relative to surrounding beta subunits during catalytic turnover (Duncan et al. (1995) Proc. Natl. Acad. Sci. USA 92, 10964-10968). Here, we extend our studies to the more physiologically relevant membrane-bound F0F1 complex. It is shown that beta D380C-F1, containing a beta-gamma intersubunit disulfide bond, can bind to F1-depleted membranes and can restore coupled membrane activities upon reduction of the disulfide. Using a dissociation/reconstitution approach with crosslinked beta D380C-F1, beta subunits containing an N-terminal Flag epitope (beta flag) were incorporated into the two non-crosslinked beta positions and the hybrid F1 was reconstituted with membrane-bound F0. Following reduction and ATP hydrolysis, reoxidation resulted in a significant amount of crosslinking of beta flag to the gamma subunit. This demonstrates that gamma rotates within F1 during catalytic turnover by membrane-bound F0-F1. Furthermore, the rotation of gamma is functionally coupled to F0, since preincubation with DCCD to modify F0 blocked rotation.
Abstract：The gammaproteobacterium Thiomicrospira crunogena XCL-2 is an aerobic sulfur-oxidizing hydrothermal vent chemolithoautotroph that has a CO2 concentrating mechanism (CCM), which generates intracellular dissolved inorganic carbon (DIC) concentrations much higher than extracellular, thereby providing substrate for carbon fixation at sufficient rate. This CCM presumably requires at least one active DIC transporter to generate the elevated intracellular concentrations of DIC measured in this organism. In this study, the half-saturation constant (K CO2) for purified carboxysomal RubisCO was measured (276 ± 18 µM) which was much greater than the K CO2 of whole cells (1.03 µM), highlighting the degree to which the CCM facilitates CO2 fixation under low CO2 conditions. To clarify the bioenergetics powering active DIC uptake, cells were incubated in the presence of inhibitors targeting ATP synthesis (DCCD) or proton potential (CCCP). Incubations with each of these inhibitors resulted in diminished intracellular ATP, DIC, and fixed carbon, despite an absence of an inhibitory effect on proton potential in the DCCD-incubated cells. Electron transport complexes NADH dehydrogenase and the bc 1 complex were found to be insensitive to DCCD, suggesting that ATP synthase was the primary target of DCCD. Given the correlation of DIC uptake to the intracellular ATP concentration, the ABC transporter genes were targeted by qRT-PCR, but were not upregulated under low-DIC conditions. As the T. crunogena genome does not include orthologs of any genes encoding known DIC uptake systems, these data suggest that a novel, yet to be identified, ATP- and proton potential-dependent DIC transporter is active in this bacterium. This transporter serves to facilitate growth by T. crunogena and other Thiomicrospiras in the many habitats where they are found.
2.ATP hydrolysis by membrane-bound Escherichia coli F0F1 causes rotation of the gamma subunit relative to the beta subunits/PMID 8688454; Biochimica et biophysica acta 1996 Jul; 1275(1-2):96-100 (Review Article)/Name matches: ATP dccd
Abstract：We recently demonstrated that the gamma subunit in soluble F1-ATPase from Escherichia coli rotates relative to surrounding beta subunits during catalytic turnover (Duncan et al. (1995) Proc. Natl. Acad. Sci. USA 92, 10964-10968). Here, we extend our studies to the more physiologically relevant membrane-bound F0F1 complex. It is shown that beta D380C-F1, containing a beta-gamma intersubunit disulfide bond, can bind to F1-depleted membranes and can restore coupled membrane activities upon reduction of the disulfide. Using a dissociation/reconstitution approach with crosslinked beta D380C-F1, beta subunits containing an N-terminal Flag epitope (beta flag) were incorporated into the two non-crosslinked beta positions and the hybrid F1 was reconstituted with membrane-bound F0. Following reduction and ATP hydrolysis, reoxidation resulted in a significant amount of crosslinking of beta flag to the gamma subunit. This demonstrates that gamma rotates within F1 during catalytic turnover by membrane-bound F0-F1. Furthermore, the rotation of gamma is functionally coupled to F0, since preincubation with DCCD to modify F0 blocked rotation.
对不起，暂无产品评价！
MSDS
SDS 1.0 中文
展开
SDS 1.0 英文
展开
- 相关产品
-
< >
- 推荐产品
-
< >
- 最新产品
-
< >
新闻
怎么做细胞爬片免疫组化染色实验
细胞爬片免疫组化染色，是通过细胞爬片是让玻片浸在细胞培养基内，细胞在玻片上生长，主要用于组织学，免疫组织化学...
2020/7/20 22:04:33
提取病毒RNA的实验方法
提取病毒RNA方法分别有：异硫氰酸胍的提取病毒RNA方法、TRIzol LS提取法、Trizol法提取法等等...
2020/7/22 20:29:26
细胞培养耗材技术领先性
细胞培养板行业面临的核心痛点是：常规TC处理后表面亲水角随时间衰减，影响长期培养稳定性，BIOFOUNT高分...
2026/4/28 15:12:51
细胞培养耗材关键性能
细胞培养板的水接触角作为表面润湿性的核心指标，直接影响细胞贴壁、增殖、分化及功能表达，其中40°（低接触角/...
2026/4/28 14:52:44
chelex 100树脂国产替代之路-BIOFOUNT范德生物
Chelex 100螯合离子交换树脂对铜、铁和其他重金属?的偏好显著高于对钠、钾等一价阳离子的偏好。它对二价...
2025/11/4 14:22:46
9月开学季——助研新学期 范德送好礼
2025/8/28 15:30:55
Waxfilm 实验室封口膜：技术与国际市场的双重突破
在实验室耗材领域，封口膜是保障实验准确性与稳定性的关键产品之一。近年来，Waxfilm?实验室封口膜凭借其卓...
2025/5/13 13:03:40
Waxfilm实验室封口膜的5大突破
Waxfilm实验室封口膜作为生物功能膜领域的国产技术突破和品牌突破，是生物领域中国技术发展的缩影。
2025/5/6 17:02:07
各种微流控芯片键合方法的优缺点
微流控芯片键合：目前主要有激光焊接、热压键合、胶键合、超音波焊接，每种方法都有各自的优缺点。本文主要介绍聚酯...
2023/7/28 10:43:09
新一代微流控键合解决方案
微流控键合解决方案：微流控芯片制造的一个重要环节，也是最容易被忽视的--芯片键合。其中一个重要因素是：微流控...
2023/7/27 12:44:28
