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Sodium Cholate
NMR and HPLC COA下载 MSDS下载 - Names：
Sodium Cholate;去垢剂
- CAS号：
361-09-1
MDL Number： MFCD00064138 - MF(分子式)： C24H39NaO5 MW(分子量)： 430.56
- EINECS:206-643-5 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
胆酸钠是一种含有 14 mM CMC 的阴离子去污剂。 由于三个羟基位于类固醇环上，一个羧基位于分子结构的末端，因此分子中没有明确的亲油或亲水区域。 一般来说，胆酸盐去垢剂可以很容易地通过透析去除，因为它们的胶束尺寸相当小。
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| SS0072-10g | 10g | BR | ¥ 150.00 | ¥ 150.00 | 3-5days | ¥ 0.00 | ||
| SS0072-100g | 100g | BR | ¥ 998.00 | ¥ 998.00 | 3-5days | ¥ 0.00 | ||
| SS0072-25g | 25g | BR | ¥ 288.00 | ¥ 288.00 | 3-5days | ¥ 0.00 |
| 中文别名 | 361-09-1;胆酸钠;3α,7α,12α-三羟基-5β-胆烷酸单钠盐;牛羊胆酸;胆酸钠盐;胆酸钠(高纯);胆酸钠,从牛胆中所得;胆酸钠去垢剂;Sodium Cholate去垢剂 |
| 英文别名 | Sodium Cholate;Cholic acid sodium salt hydrate;Cholic acid, sodium salt;Cholic acid, monosodium salt |
| CAS号 | 361-09-1 |
| Inchi | InChI=1S/C24H40O5.Na/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);/q;+1/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;/m1./s1 |
| InchiKey | NRHMKIHPTBHXPF-TUJRSCDTSA-M |
| 分子式 Molecular Weight | C24H39NaO5 |
| 分子量 Formula | 430.56 |
| 溶解度Solubility | H2O : ≥ 250 mg/mL (580.65 mM) |
| 性状 | 白色至灰白色固体粉末 |
| 储藏条件 Storage conditions | Store at 4°C,-4℃下存储更优 |
Sodium Cholate介绍：
Sodium Cholate 是一种含有 14 mM CMC 的阴离子去污剂。 由于三个羟基位于类固醇环上，一个羧基位于分子结构的末端，因此分子中没有明确的亲油或亲水区域。 一般来说，胆酸盐洗涤剂可以很容易地通过透析去除，因为它们的胶束尺寸相当小。
膜蛋白：
1. 足够的蛋白质溶解能力
2. 不使蛋白质变性或失活
3. 不干扰蛋白质活性
4. 4℃无沉淀
5. 适当的临界胶束浓度 (CMC) 和胶束大小
6. 紫外区无吸收
7. 无毒性
8. 洗涤剂检测方法的可用性
9. 如果使用离子交换色谱，非离子去污剂
Chemical Structure
胆酸钠(361-09-1,Sodium Cholate)毒理属性测试：
| 生物 | 测试类型 | 路线 | 报告剂量（标准化剂量） | 影响 | 参考 |
|---|---|---|---|---|---|
| rat | LDLo | oral | 713 mg/kg (713 mg/kg) | BEHAVIORAL: COMA; CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE; VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of the Formosan Medical Association., 91(743), 1992 [PMID:1362110] |
| mouse | LD50 | oral | 2400 mg/kg (2400 mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY); GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH; GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE | Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences., (103)(29), 1985 [PMID:3830311] |
| mouse | LD50 | intraperitoneal | 164 mg/kg (164 mg/kg) | BEHAVIORAL: EXCITEMENT; LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES; GASTROINTESTINAL: HYPERMOTILITY, DIARRHEA | Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences., (103)(29), 1985 [PMID:3830311] |
| mouse | LD50 | intravenous | 200 mg/kg (200 mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie., 90(18), 1952 [PMID:12977382] | |
| rabbit | LDLo | intravenous | 50 mg/kg (50 mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Zeitschrift fuer die Gesamte Experimentelle Medizin., 52(779), 1926 |
胆酸钠(361-09-1,Sodium Cholate)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净后，烘干消毒存放。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
Sodium Cholate(361-09-1) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:胆酸钠(361-09-1,Sodium Cholate),胆酸钠试剂,胆酸钠的作用,胆酸钠的产量,胆酸钠的纯度,胆酸钠的生产厂家,胆酸钠的价格,胆酸钠的外观,胆酸钠的储存条件,胆酸钠的溶解度,胆酸钠的MSDS,胆酸钠的结构式,胆酸钠的注意事项
| 产品说明 | 胆酸钠是一种含有 14 mM CMC 的阴离子去污剂。 由于三个羟基位于类固醇环上，一个羧基位于分子结构的末端，因此分子中没有明确的亲油或亲水区域。 一般来说，胆酸盐去垢剂可以很容易地通过透析去除，因为它们的胶束尺寸相当小。 |
| Introduction | Sodium cholate is an anionic detergent with 14 mM CMC. Since three hydroxy groups are located on a steroid ring and one carboxylic group is at the terminus of the molecular structure, there are no def |
| Application1 | |
| Application2 | |
| Application3 |
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | No data available |
| 安全声明 | H303吞入可能有害+H313皮肤接触可能有害+H333吸入可能对身体有害 |
| 安全防护 | P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P313获得医疗建议/护理 |
| 备注 | 实验过程中防止吸入、食入，做好安全防护 |
| 象形图 |  |
|---|---|
| 信号 | Warning |
| GHS危险说明 |
H315 (60%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (60%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (60%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] H412 (40%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] |
| 防范说明代码 |
P261, P264, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Amino-functionalized cellulose: a novel and high-efficiency scavenger for sodium cholate sorption(Cellulose,2020) |
| Concentration-dependent effects of sodium cholate and deoxycholate bile salts on breast cancer cells proliferation and survival(Molecular Biology Reports,2020) |
| Assembly properties of the aggregates resulting in the solubilization of phosphatidylcholine bilayers by sodium cholate(Journal of Surfactants and Detergents,1998) |
| Increasing the Bile Acid Sequestration Performance of Cationic Hydrogels by Using an Advanced/Controlled Polymerization Technique(Pharmaceutical Research,2017) |
| Characterization of aggregate structures of phospholipid in the process of vesicle solubilization with sodium cholate using laser light scattering method(Colloid and Polymer Science,2002) |
1.Ultradeformable Archaeosomes for Needle Free Nanovaccination with Leishmania braziliensis Antigens.
Higa LH1, Arnal L2, Vermeulen M3, Perez AP1, Schilrreff P1, Mundiña-Weilenmann C4, Yantorno O5, Vela ME2, Morilla MJ1, Romero EL1. PLoS One. 2016 Mar 2;11(3):e0150185. doi: 10.1371/journal.pone.0150185. eCollection 2016.
Total antigens from Leishmania braziliensis promastigotes, solubilized with sodium cholate (dsLp), were formulated within ultradeformable nanovesicles (dsLp-ultradeformable archaeosomes, (dsLp-UDA), and dsLp-ultradeformable liposomes (dsLp-UDL)) and topically administered to Balb/c mice. Ultradeformable nanovesicles can penetrate the intact stratum corneum up to the viable epidermis, with no aid of classical permeation enhancers that can damage the barrier function of the skin. Briefly, 100 nm unilamellar dsLp-UDA (soybean phosphatidylcholine: Halorubrum tebenquichense total polar lipids (TPL): sodium cholate, 3:3:1 w:w) of -31.45 mV Z potential, containing 4.84 ± 0.53% w/w protein/lipid dsLp, 235 KPa Young modulus were prepared. In vitro, dsLp-UDA was extensively taken up by J774A1 and bone marrow derive cells, and the only that induced an immediate secretion of IL-6, IL-12p40 and TNF-α, followed by IL-1β, by J774A1 cells. Such extensive uptake is a key feature of UDA ascribed to the highly negatively charged archaeolipids of the TPL, which are recognized by a receptor specialized in uptake and not involved in downstream signaling.
2.Biosurfactant templated quantum sized fluorescent gold nanoclusters for in vivo bioimaging in zebrafish embryos.
S C1, C C2, T M1, G S2, N R3. Colloids Surf B Biointerfaces. 2016 Mar 24;143:472-480. doi: 10.1016/j.colsurfb.2016.03.067. [Epub ahead of print]
We report the biosurfactant (sodium cholate) templated bright bluish-green emitting gold nanoclusters (AuNCs) by green chemical approach. Optical properties of the AuNCs were studied using UV-vis and luminescence spectroscopy. Lifetime of the fluorescent AuNCs was measured using time correlated single photon counting technique (TCSPC). High-resolution transmission electron microscopy (HR-TEM) and dynamic light scattering (DLS) were used to measure the sizes of the clusters. In-vivo toxicity and bioimaging studies of sodium cholate (NaC) templated AuNCs were carried out at different developmental stages of zebrafish embryos. The survival rate, hatching rate, heart rate, malformation and apoptotic gene expression experiments shows no significant toxicity in developing embryos up to 100μL/mL of AuNCs concentration and the AuNCs stained embryos exhibited green fluorescence with high intensity over the period from 4 to 96hpf (hours post fertilization) which shows that AuNCs were stable in living organisms.
3.Absorption mechanism of oxymatrine in cultured Madin-Darby canine kidney cell monolayers.
Xiong XH1, Huang LH1, Zhong YM1, Cheng XG1, Cen MF1, Wang GX1, Zang LQ1, Wang SJ1. Pharm Biol. 2016 Mar 17:1-8. [Epub ahead of print]
Context Oxymatrine (OMT) is beneficial to human health by exerting various biological effects. Objective To investigate the absorption mechanism of OMT and discover absorption enhancers using Madin-Darby canine kidney (MDCK) cell monolayers. Materials and methods Concentration effects on the transport of OMT were measured in the range of 1.0 × 10-5-1.0 × 10-3 M in 2 h. Then, the effect of time, direction, temperature and pH on the transport of OMT at 10-4 M was studied. Moreover, Papp of OMT was determined in the absence/presence of cyclosporine and surfactants at 100 μM to further confirm the relative transport mechanism. Results The Papp AP→BL ranged from (3.040 ± 0.23) × 10-6 to (3.697 ± 0.19) × 10-6 cm/s as the concentration varied from 10-5 to 10-3 M. OMT showed similar Papp at 4 and 37 °C (p > 0.05). Increasing the apical pH 7.4 and 8.0 resulted in Papp versus pH 5.0 (p < 0.01). Furthermore, in the presence of cyclosporine and surfactants including sodium citrate, sodium dodecyl sulphate (SDS) and deoxysodium cholate, Papp was (0.
4.Hypoglycemic activity and stability enhancement of human insulin-tat mixture loaded in elastic anionic niosomes.
Manosroi A1,2,3, Tangjai T1,2,3, Sutthiwanjampa C2, Manosroi W4, Werner RG5, Götz F5, Sainakham M1,2, Manosroi J1,2,3. Drug Deliv. 2016 Mar 16:1-11. [Epub ahead of print]
This study aimed to investigate the synergistic effect of trans-activator of transcription (Tat) and niosomes for the improvement of hypoglycemic activity of orally delivered human insulin. The elastic anionic niosomes composing of Tween 61/cholesterol/dicetyl phosphate/sodium cholate at 1:1:0.05:0.02 molar ratio loaded with insulin-Tat mixture (1:3 molar ratio) was prepared. Deformability of the elastic anionic niosomes decreased after loaded with the mixture of 1.35 times. For the in vitro release, the insulin (T10 = 4 h) loaded in the elastic anionic niosomes indicated the slower release rate than insulin in the mixture (T10 = 3 h) loaded in niosomes. At room temperature (30 ± 2 °C), the mixture loaded in elastic anionic niosomes was more chemical stable than the free mixture of 1.3, 1.4 and 1.7 times after stored for 4, 8 and 12 weeks, respectively. Oral administration in the alloxan-induced diabetic mice of the mixture loaded in elastic anionic niosomes with the insulin doses at 25, 50 and 100 IU/kg body weight indicated significant hypoglycemic activity with the percentage fasting blood glucose reduction of 1.
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