购物车 
-
Paclitaxel
NMR and HPLC COA下载 MSDS下载 - Names：
Paclitaxel, Anticancer agent
- CAS号：
33069-62-4
MDL Number： MFCD00869953 - MF(分子式)： C47H51NO14 MW(分子量)： 853.91
- EINECS:608-826-9 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
紫杉醇(Paclitaxel,33069-62-4)是从紫杉中提取的具有抗肿瘤活性的化合物。 紫杉醇与微管蛋白结合并抑制微管的分解，从而导致细胞分裂的抑制。 该产品还通过与凋亡抑制蛋白Bcl-2（B细胞白血病2）结合并阻断其功能来诱导凋亡。
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| FMK23662-2g | 2g | >98% | ¥ 3500.00 | ¥ 3500.00 | Same day | ¥ 0.00 | ||
| FMK23662-1g | 1g | >98% | ¥ 150.00 | ¥ 150.00 | Same day | ¥ 0.00 | ||
| SY0241-10mg | 10mg | 98% | ¥ 139.00 | ¥ 139.00 | Instock | ¥ 0.00 |
| 中文别名 | 紫杉醇(33069-62-4);特素;红豆杉提取物;合成紫杉醇;紫素泰素 |
| 英文别名 | Paclitaxel(33069-62-4);paclitaxel; Taxol A; Abraxane; Yewtaxan; Paxene; ABI-007; Intaxel; Paclitaxel (Taxol); Pacliex; ABI 007 |
| CAS号 | 33069-62-4 |
| Inchi | InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1 |
| InchiKey | RCINICONZNJXQF-MZXODVADSA-N |
| 分子式 Molecular Weight | C47H51NO14 |
| 分子量 Formula | 853.91 |
| 溶解度Solubility | Soluble in ethanol (~1.5 mg/ml), DMSO (5 mg/ml), acetonitrile, methanol (50 mg/ml), chloroform, 1:10 DMSO:PBS(pH 7.2) (~0.1 mg/ml), and DMF (~5 mg/ml). Insoluble in water. |
| 性状 | 白色至类白色固体 |
| 储藏条件 Storage conditions | 储存温度2-8°C |
紫杉醇(Paclitaxel,33069-62-4)毒理性质：
紫杉醇(CAS:33069-62-4;英文名:Paclitaxel;)实验注意事项：
1.使用33069-62-4实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.使用33069-62-4实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品33069-62-4的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品33069-62-4时尽量采用多个药勺分别使用，使用后清洗干净。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
大规格定制：定制产品请将信息发送至sales@bio-fount.com。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:紫杉醇蒸汽压,紫杉醇合成,紫杉醇标准,紫杉醇应用,紫杉醇合成,紫杉醇沸点,紫杉醇闪点,紫杉醇用途,紫杉醇溶解度,紫杉醇价格,紫杉醇作用,紫杉醇结构式,紫杉醇用处
| 动物 | 测试类型 | 途径 | 实验摄入量 (标准摄入量) | 影响 | 文献来源 |
| dog | LDLo | intravenous | 15mg/kg (15mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
National Technical Information Service. Vol. PB83-170969, |
| mouse | LD50 | intraperitoneal | 128mg/kg (128mg/kg) | National Technical Information Service. Vol. PB83-170969, | |
| mouse | LD50 | intraperitoneal | 128mg/kg (128mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER | National Technical Information Service. Vol. PB83-170969, |
| mouse | LD50 | intravenous | 12mg/kg (12mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Pharmaceutical Research. Vol. 4, Pg. 162, 1987. |
| rat | LD50 | intraperitoneal | 32530ug/kg (32.53mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
National Technical Information Service. Vol. PB83-170969, |
| rat | LDLo | intravenous | 85mg/kg (85mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE |
Journal of Toxicological Sciences. Vol. 19(Suppl, |
| women | LDLo | intravenous | 4995mg/kg/3H- (4995mg/kg) | BLOOD: LEUKOPENIA CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION BLOOD: THROMBOCYTOPENIA |
Lancet. Vol. 343, Pg. 727, 1994. |
紫杉醇(CAS:33069-62-4;英文名:Paclitaxel;)实验注意事项：
1.使用33069-62-4实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.使用33069-62-4实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品33069-62-4的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品33069-62-4时尽量采用多个药勺分别使用，使用后清洗干净。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
大规格定制：定制产品请将信息发送至sales@bio-fount.com。
Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:紫杉醇蒸汽压,紫杉醇合成,紫杉醇标准,紫杉醇应用,紫杉醇合成,紫杉醇沸点,紫杉醇闪点,紫杉醇用途,紫杉醇溶解度,紫杉醇价格,紫杉醇作用,紫杉醇结构式,紫杉醇用处
| 产品说明 | 紫杉醇(33069-62-4)是一种微管聚合物稳定剂,作用于人内皮细胞,IC50为0.1pM.紫杉醇溶解度,紫杉醇MSDS,紫杉醇结构式,紫杉醇应用详见主页. |
| Introduction | Paclitaxel(紫杉醇,33069-62-4) is a compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. |
| Application1 | |
| Application2 | 结合β-微管蛋白的N -端区域，促进了高度稳定的微管形成体，抵制解聚，防止正常细胞分裂和捕获在细胞周期的G2 / M期 |
| Application3 |
1.A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2).
2.A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
2.A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | Not Available |
| 安全声明 | H318,H361f,H341,H332,H312,H302,H335,H315,H334,H317 |
| 安全防护 | P280,P305+P351+P338,P260,P261,P342+P311 |
| 备注 | 避免吸入，误食以及与皮肤接触 |
| Hendricus B. A. de Bont, Ruben G. G. Leenders, Johan W. Scheeren, Hidde J. Haisma, Dick de Vos, "Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy." U.S. Paten |
| Wall ME, Wani MC: Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture. Cancer Res. 1995 Feb 15;55(4):753-60. [PMID:7850785] |
| Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT: Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc. 1971 |
| Fuchs DA, Johnson RK: Cytologic evidence that taxol, an antineoplastic agent from Taxus brevifolia, acts as a mitotic spindle poison. Cancer Treat Rep. 1978 Aug;62(8):1219-22. [PMID:688258] |
| Saville MW, Lietzau J, Pluda JM, Feuerstein I, Odom J, Wilson WH, Humphrey RW, Feigal E, Steinberg SM, Broder S, et al.: Treatment of HIV-associated Kaposi's sarcoma with paclitaxel. Lancet. 1995 Jul |
1.Polymerprodrug approaches applied to paclitaxel / Jeong Sun Sohn,a Jung Il Jin,b Michael Hesscd and Byung Wook Jo*d
Abstract:Paclitaxel possesses a unique mechanism of drug action as a new class of microtubule stabilizing agent which finally leads to disrupted mitosis and cell death. Recent findings have shown that paclitaxel initiates apoptosis through multiple mechanisms. However, the strong hydrophobicity of paclitaxel drastically limits its use in natural form. In addition, significant toxicity which is mainly ascribed to the non-specific, indiscriminate distribution among the tissues limited the application of paclitaxel in cancer therapy. Therefore, it remains of interest to improve their use by enhancing solubility, selectivity and in vivo delivery by preparing functional prodrugs selectively activable in tumour areas. This article summarizes results and information derived recently from paclitaxel prodrugs based mainly on macromolecular conjugates and their interactions with body fluids. We also explore the potential application of site-specific carriers in the development of tumor-targeting paclitaxel conjugates.
2.Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics/Dirk R. Albrecht, Gregory H. Underhill, Joshua Resnikoff, Avital Mendelson, Sangeeta N. Bhatia, Jagesh V. Shah/Integrative Biology, Volume 2, Issue 5-6, June 2010, Pages 278–287, https://doi.org/10.1039/b923699f
Abstract:An understanding of the mechanisms regulating cellular responses has recently been augmented by innovations enabling the observation of phenotypes at high spatio-temporal resolution. Technologies such as microfluidics have sought to expand the throughput of these methods, although assimilation with advanced imaging strategies has been limited. Here, we describe the pairing of high resolution time-lapse imaging with microfluidic multiplexing for the analysis of cellular dynamics, utilizing a design selected for facile fabrication and operation, and integration with microscopy instrumentation. This modular, medium-throughput platform enables the long-term imaging of living cells at high numerical aperture (via oil immersion) by using a conserved 96-well, ∼6 × 5 mm2 imaging area with a variable input/output channel design chosen for the number of cell types and microenvironments under investigation. In the validation of this system, we examined fundamental features of cell cycle progression, including mitotic kinetics and spindle orientation dynamics, through the high-resolution parallel analysis of model cell lines subjected to anti-mitotic agents. We additionally explored the self-renewal kinetics of mouse embryonic stem cells, and demonstrate the ability to dynamically assess and manipulate stem cell proliferation, detect rare cell events, and measure extended time-scale correlations. We achieved an experimental throughput of >900 cells/experiment, each observed at >40× magnification for up to 120 h. Overall, these studies illustrate the capacity to probe cellular functions and yield dynamic information in time and space through the integration of a simple, modular, microfluidics-based imaging platform.
3.Linear release nanoparticle devices for advanced targeted cancer therapies with increased efficacy†/Alice E. van der Ende,a Vasanth Sathiyakumar,a Roberto Diaz,‡b Dennis E. Hallahan§b and Eva Harth*a
Abstract:The cross-linked supramolecular structure of prepared polyester based nanoparticles enable increased and efficient small molecule drug loading after nanoparticle formation and post-modification with targeting peptides via thiol-ene ‘click’ chemistry. It could be demonstrated that the drug loading does not influence the structural integrity of the particle and its diameter was not significantly changed. A prolonged linear release profile of the drug without the typical ‘burst effect’ was observed in emulsified particles and mirrored the linear degradation profile of the investigated particles, which are critical properties for controlled and predictable pharmacokinetics in cancer therapies. Furthermore, the final peptide-targeted and drug-loaded particles were found to be readily dispersed in buffer or water, and with the confirmed biocompatibility, these novel and adjustable drug delivery systems are promising vectors for the treatment of various cancers.
Abstract:Paclitaxel possesses a unique mechanism of drug action as a new class of microtubule stabilizing agent which finally leads to disrupted mitosis and cell death. Recent findings have shown that paclitaxel initiates apoptosis through multiple mechanisms. However, the strong hydrophobicity of paclitaxel drastically limits its use in natural form. In addition, significant toxicity which is mainly ascribed to the non-specific, indiscriminate distribution among the tissues limited the application of paclitaxel in cancer therapy. Therefore, it remains of interest to improve their use by enhancing solubility, selectivity and in vivo delivery by preparing functional prodrugs selectively activable in tumour areas. This article summarizes results and information derived recently from paclitaxel prodrugs based mainly on macromolecular conjugates and their interactions with body fluids. We also explore the potential application of site-specific carriers in the development of tumor-targeting paclitaxel conjugates.
2.Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics/Dirk R. Albrecht, Gregory H. Underhill, Joshua Resnikoff, Avital Mendelson, Sangeeta N. Bhatia, Jagesh V. Shah/Integrative Biology, Volume 2, Issue 5-6, June 2010, Pages 278–287, https://doi.org/10.1039/b923699f
Abstract:An understanding of the mechanisms regulating cellular responses has recently been augmented by innovations enabling the observation of phenotypes at high spatio-temporal resolution. Technologies such as microfluidics have sought to expand the throughput of these methods, although assimilation with advanced imaging strategies has been limited. Here, we describe the pairing of high resolution time-lapse imaging with microfluidic multiplexing for the analysis of cellular dynamics, utilizing a design selected for facile fabrication and operation, and integration with microscopy instrumentation. This modular, medium-throughput platform enables the long-term imaging of living cells at high numerical aperture (via oil immersion) by using a conserved 96-well, ∼6 × 5 mm2 imaging area with a variable input/output channel design chosen for the number of cell types and microenvironments under investigation. In the validation of this system, we examined fundamental features of cell cycle progression, including mitotic kinetics and spindle orientation dynamics, through the high-resolution parallel analysis of model cell lines subjected to anti-mitotic agents. We additionally explored the self-renewal kinetics of mouse embryonic stem cells, and demonstrate the ability to dynamically assess and manipulate stem cell proliferation, detect rare cell events, and measure extended time-scale correlations. We achieved an experimental throughput of >900 cells/experiment, each observed at >40× magnification for up to 120 h. Overall, these studies illustrate the capacity to probe cellular functions and yield dynamic information in time and space through the integration of a simple, modular, microfluidics-based imaging platform.
3.Linear release nanoparticle devices for advanced targeted cancer therapies with increased efficacy†/Alice E. van der Ende,a Vasanth Sathiyakumar,a Roberto Diaz,‡b Dennis E. Hallahan§b and Eva Harth*a
Abstract:The cross-linked supramolecular structure of prepared polyester based nanoparticles enable increased and efficient small molecule drug loading after nanoparticle formation and post-modification with targeting peptides via thiol-ene ‘click’ chemistry. It could be demonstrated that the drug loading does not influence the structural integrity of the particle and its diameter was not significantly changed. A prolonged linear release profile of the drug without the typical ‘burst effect’ was observed in emulsified particles and mirrored the linear degradation profile of the investigated particles, which are critical properties for controlled and predictable pharmacokinetics in cancer therapies. Furthermore, the final peptide-targeted and drug-loaded particles were found to be readily dispersed in buffer or water, and with the confirmed biocompatibility, these novel and adjustable drug delivery systems are promising vectors for the treatment of various cancers.
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