盐酸小檗碱

1.The therapeutic potential of Berberine chloride hydrate against harmaline-induced motor impairments in a rat model of tremor/PMID 25643620; Neuroscience letters 2015 Mar; 590(?):84-90/Name matches: essential tremor berberine chloride hydrate
Abstract:Essential tremor (ET) is a progressive neurological disorder with motor and non-motor symptoms. It has conclusively been shown that modulation of glutamate receptors could ameliorate ET. Recent studies have suggested that Berberine (BBR) has an inhibitory effect on glutamate receptors. Therefore, BBR may have therapeutic effects on ET. In this study, male Wistar rats (n=10 in each group) weighing 40-60 g were divided into control, harmaline (30 mg/kg, i.p.) and berberine (10, 20 or 50mg/kg, i.p, 15 min before harmaline injection) groups. Open field, rotarod, wire grip and foot print tests were used to evaluate motor performance. The results indicated that the administration of BBR (10 and 20mg/kg) attenuated harmaline-induced tremor in rats, but the beneficial effects of BBR could not be identified at dose 50mg/kg. In addition, BBR ameliorated gait disturbance in doses of 10 and 20mg/kg. The high dose of BBR not only failed to recover step width but also showed an adverse effect on left and right step length. The results indicate that BBR only in dose of 20mg/kg recovers mobility duration. The current study found a dose-dependent manner for the therapeutic effects of BBR in ET. Our study provides the initial evidence for the effects of BBR on motor function. Since BBR exerts its effects mainly through regulation of neurotransmitter release or blocke of NMDA receptors, thus, it is predicted that BBR ameliorate harmaline effect through blockade of NMDA receptors or glutamate release. This is an important issue for future research to evaluate the possible mechanisms involved.

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2.Highly selective fluorescent visual detection of perfluorooctane sulfonate via blue fluorescent carbon dots and berberine chloride hydrate/PMID 30253323; Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2019 Jan; 207(?):262-269/Name matches: perfluorooctanesulfonate berberine chloride hydrate
Abstract:As a kind of emerging persistent organic pollutants, perfluorooctane sulfonate (PFOS) and its salts have caused global ecosystem pollution. To develop rapid, sensitive and low-cost detection method of PFOS is of great importance. In this work, a novel sensing method has been proposed for the highly selective fluorescent visual detection of PFOS in aqueous solution based on carbon dots (CDs) and berberine chloride hydrate (BH). It was found that the fluorescence of CDs decreased apparently in the presence of berberine chloride hydrate in pH 6.09 Britton-Robinson (BR) buffer solution. When PFOS was added to the system, the fluorescence was restored slightly at 448 nm and enhanced apparently at 533 nm, but no phenomenon occurred with other perfluorinated compounds. As a consequence, an obviously distinguishable fluorescence color variation (from blue to light yellow) of solution was observed. Under the optimized experimental conditions, the enhanced fluorescence intensities at 533 nm are in proportion to the concentration of PFOS in the range of 0.22-50.0 μmol/L (R2 = 0.9919), with a detection limit of 21.7 nmol/L (3σ). The proposed approach has been successfully applied to the detection of PFOS in environmental water samples with RSD ≤ 1.1%.