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Tunicamycin
NMR and HPLC COA下载 MSDS下载 - Names：
Tunicamycin, Protein glycosylation inhibitor
- CAS号：
11089-65-9
MDL Number： MFCD00065709 - MF(分子式)： C38H62N4O16 (Tun B) MW(分子量)： 840
- EINECS:601-012-4 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| YZM000005-25mg | 25mg | 98% | ¥ 5200.00 | ¥ 5200.00 | Instock1-2days | ¥ 0.00 | ||
| YZM000005-10mg | 10mg | 98% | ¥ 2680.00 | ¥ 2680.00 | Instock1-2days | ¥ 0.00 | ||
| YZM000005-5mg | 5mg | 98% | ¥ 2188.00 | ¥ 2188.00 | 2-3days | ¥ 0.00 |
| 中文别名 | Tunicamycin;衣霉素(11089-65-9,Tunicamycin);衣霉素复合物;衣霉素 来源于链霉菌属;衣霉素(链霉菌属) |
| 英文别名 | Tunicamycin(11089-65-9);Tunicamycin complex;Protein glycosylation inhibitor |
| CAS号 | 11089-65-9 |
| Inchi | InChI=1S/C37H60N4O16/c1-18(2)12-10-8-6-4-5-7-9-11-13-23(45)39-26-30(50)27(47)21(54-36(26)57-35-25(38-19(3)43)29(49)28(48)22(17-42)55-35)16-20(44)33-31(51)32(52)34(56-33)41-15-14-24(46)40-37(41)53/h11,13-15,18,20-22,25-36,42,44,47-52H,4-10,12,16-17H2,1-3H3,(H,38,43)(H,39,45)(H,40,46,53)/b13-11+/t20-,21-,22+,25+,26-,27+,28+,29+,30-,31+,32-,33-,34-,35+,36+/m1/s1 |
| InchiKey | YJQCOFNZVFGCAF-WPTOCQRYSA-N |
| 分子式 Molecular Weight | C38H62N4O16 (Tun B) |
| 分子量 Formula | 840 |
| 溶解度Solubility | DMSO : 40 mg/mL (Need ultrasonic) |
| 性状 | 灰白色至浅黄色固体粉末 |
| 储藏条件 Storage conditions | Store at 4°C,-4℃下存储更优 |
案例：
Tunicamycin induced cell death and inhibition of mitochondrial respiration. (a) Cell death (Sytox-green staining) at 24 h after tunicamycin (Tm) 10 and 20 μg/ml treatment (Tm10 and Tm20); *P<0.01 versus DMSO. Z-VAD-fmk (10 μM) prevented tunicamycin-induced cell death; #P<0.01 versus Tm20. N=6 experiments. (b) Quantitation of immunostained active cleaved-caspase-3 positive cells after tunicamycin treatment; *P<0.01 versus DMSO. N=3 experiments. (c) Cytochrome c released after tunicamycin treatment (confocal image; 63X magnification). (d) Real-time continuous measurement of cellular and mitochondrial respiration (OCR) using in Seahorse XF24 analyzer. After acquisition of basal (starting) OCR, DMSO or tunicamycin 10–20 μg/ml was injected (marked as X/Y). Mitochondrial OCR after injection oligomycin (O), CCCP (C) or rotenone (R) was acquired at the end of cellular OCR measurement. No loss of viability was observed during these incubations (not shown). (e) Mitochondrial Ox-Phos OCR (OCR at 1 or 2 h–OCR after oligomycin) reflecting mitochondrial ATP generation, mitochondrial reserve-capacity (OCR after 1 or 2 h–OCR after CCCP), and proton leak (OCR after oligomycin–OCR after rotenone injection) were calculated from acquired mitochondrial OCR. The data are presented as mean±S.D. Mean of five wells for each experiment; *P<0.05 versus DMSO, N=5 experiments.
衣霉素(11089-65-9,Tunicamycin)毒理属性测试：
| 生物 | 测试类型 | 路线 | 报告剂量（标准化剂量） | 影响 | 参考 |
|---|---|---|---|---|---|
| domestic animals - goat/sheep | LDLo | subcutaneous | 20ug/kg (0.02mg/kg) | LIVER: OTHER CHANGES BEHAVIORAL: ATAXIA |
Australian Veterinary Journal. Vol. 76, Pg. 287, 1998. |
| guinea pig | LD | subcutaneous | > 400ug/kg (0.4mg/kg) | Pathology. Vol. 21, Pg. 194, 1989. | |
| guinea pig | LD | subcutaneous | > 400ug/kg (0.4mg/kg) | BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" LIVER: OTHER CHANGES |
Pathology. Vol. 21, Pg. 194, 1989. |
| rat | LD | subcutaneous | > 200ug/kg (0.2mg/kg) | Australian Veterinary Journal. Vol. 76, Pg. 287, 1998. | |
| rat | LD | subcutaneous | > 200ug/kg (0.2mg/kg) | LIVER: OTHER CHANGES | Australian Veterinary Journal. Vol. 76, Pg. 287 |
衣霉素(11089-65-9,Tunicamycin)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净后，烘干消毒存放。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
Tunicamycin(11089-65-9) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:衣霉素(11089-65-9,Tunicamycin),衣霉素的使用,衣霉素的作用,衣霉素的纯度,衣霉素的外观,衣霉素的厂家,衣霉素的价格,衣霉素的合成路线,衣霉素的溶解度,衣霉素的MSDS,衣霉素的检测,衣霉素的储存条件
| 产品说明 | 衣霉素(11089-65-9,Tunicamycin)仅做科学研究以及化学合成中间体使用,11089-65-9的熔点，11089-65-9的溶解性等参数见主页 |
| Introduction | Tunicamycin (11089-65-9,衣霉素) is only used for scientific research and chemical synthesis intermediates. The melting point of 11089-65-9 and the solubility of 11089-65-9 are available on the homepage. |
| Application1 | 在蛋白质糖基化过程中，衣霉素被认为是在与多元醇连接的糖蛋白合成过程中糖部分转移至多元醇的抑制剂。 |
| Application2 | 衣霉素可以作为糖蛋白合成的竞争性抑制剂来阻止细胞循环。 |
| Application3 | 衣霉素可预防大鼠神经胶质细胞原代培养中的细胞周期进程，并以剂量??依赖性方式抑制鸡或小鼠成纤维细胞中脂质介导的蛋白质糖基化。 |
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | No data available |
| 安全声明 | H300 |
| 安全防护 | P264,P301+P310 |
| 备注 | 实验过程中防止吸入、食入，做好安全防护 |
| 1. Hu S et al. Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-?-catenin-STAT3 signaling. Cell Death Differ 29:642-656 (2022). |
| 2. Hou H, et al. DPAGT1/Akt/ABCG2 pathway in mouse Xenograft models of human hepatocellular carcinoma. Mol Cancer Ther. 2013 Dec;12(12):2874-84. |
| 3. Han C, et al. Endoplasmic reticulum stress inhibits cell cycle progression via induction of p27 in melanoma cells. Cell Signal. 2013 Jan;25(1):144-9. |
| 4. Kathleen M McAndrews, et al. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 2019 Mar 30;18(1):52. |
| 5. Langan, T.J. and Slater, M.C. 1991. J. Cell Physiol. 149: 284-292. PMID: 1748720 |
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