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柚皮苷
NMR and HPLC COA下载 MSDS下载 - Names：
Naringin
- CAS号：
10236-47-2
MDL Number： MFCD00148888 - MF(分子式)： C27H32O14 MW(分子量)： 580.53
- EINECS:233-566-4 Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
柚皮苷(10236-47-2,Naringin)是一种柑橘类生物类黄酮，可抑制小鼠肝脏中细胞色素P450单加氧酶的活性。 柚皮苷可防止毒素诱导的细胞骨架破坏和凋亡性肝细胞死亡。 另外，发现柚皮苷通过抑制HMG-CoA还原酶以及ACAT活性具有降胆固醇的作用。 柚皮苷是CYP1A2和CYP3A4的抑制剂。 柚皮苷是OATP的抑制剂。
| 货品编码 | 规格 | 纯度 | 价格 (¥) | 现价(¥) | 特价(¥) | 库存描述 | 数量 | 总计 (¥) |
|---|---|---|---|---|---|---|---|---|
| YZM001963-10g | 10g | 99.79% | ¥ 708.00 | ¥ 708.00 | 2-3天 | ¥ 0.00 | ||
| YZM003783-200mg | 200mg | 99.79% | ¥ 483.75 | ¥ 483.75 | In-stock | ¥ 0.00 | ||
| YZM001963-200mg | 200mg | 99.79% | ¥ 487.50 | ¥ 487.50 | 2-3天 | ¥ 0.00 | ||
| FMK22648-10g | 10g | >98% | ¥ 4480.00 | ¥ 4480.00 | 2 Weeks | ¥ 0.00 | ||
| FMK22648-5g | 5g | >98% | ¥ 195.00 | ¥ 195.00 | 2 Weeks | ¥ 0.00 | ||
| SY0168-100g | 100g | 95% | ¥ 398.00 | ¥ 398.00 | Instock | ¥ 0.00 | ||
| SY0168-25g | 25g | 95% | ¥ 128.00 | ¥ 128.00 | Instock | ¥ 0.00 |
| 中文别名 | 柚皮苷(10236-47-2,Naringin);柚甙;纳米脂质体柚皮苷;柚皮苷(分析标准品);柚皮甙水合物 |
| 英文别名 | Naringin(10236-47-2);Naringoside;Naringin hydrate;Naringenin 7-O-neohesperidoside;Naringenin 7-Rhamnoglucoside |
| CAS号 | 10236-47-2 |
| Inchi | InChI=1S/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1 |
| InchiKey | DFPMSGMNTNDNHN-ZPHOTFPESA-N |
| 分子式 Molecular Weight | C27H32O14 |
| 分子量 Formula | 580.53 |
| 溶解度Solubility | DMSO : 1 mg/mL (1.72 mM; Need ultrasonic) H2O : 1 mg/mL (1.72 mM; ultrasonic and warming and heat to 80°C) Ethanol : < 1 mg/mL (insoluble) |
| 性状 | 白色至灰白色固体粉末 |
| 储藏条件 Storage conditions | Store at 4°C,-4℃下存储更优 |
柚皮苷(10236-47-2,Naringin)毒理属性测试：
| 生物 | 测试类型 | 路线 | 报告剂量（标准化剂量） | 影响 | 参考 |
|---|---|---|---|---|---|
| guinea pig | LD50 | intraperitoneal | 2 gm/kg (2000 mg/kg) | Eksperimentalna Meditsina i Morfologiya., 19(207), 1980 [PMID:7460808] | |
| rat | LD50 | intraperitoneal | 2 gm/kg (2000 mg/kg) | Eksperimentalna Meditsina i Morfologiya., 19(207), 1980 [PMID:7460808] |
柚皮苷(10236-47-2,Naringin)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。
3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。
4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。
5.取药品时尽量采用多个药勺分别使用，使用后清洗干净后，烘干消毒存放。
6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。
Naringin(10236-47-2) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.
Tag:柚皮苷(10236-47-2,Naringin),柚皮苷试剂,柚皮苷的纯度,柚皮苷的结构式,柚皮苷的外观,柚皮苷的生产厂家,柚皮苷的溶解度,柚皮苷的价格,柚皮苷的MSDS,柚皮苷的储存条件,柚皮苷的注意事项,柚皮苷的成分
| 产品说明 | 柚皮苷(10236-47-2,Naringin)仅做科学研究以及化学合成中间体使用,10236-47-2的结构式、10236-47-2的MSDS等参数见主页 |
| Introduction | Naringin (10236-47-2,柚皮苷) is only used for scientific research and chemical synthesis intermediates. For the structural formula of 10236-47-2, the MSDS of 10236-47-2 and other parameters, please |
| Application1 | 柚皮苷可用作食用添加剂，主要用于口香糖，清凉饮料等。 |
| Application2 | 柚皮苷是一种柑橘类生物类黄酮，可抑制小鼠肝脏中细胞色素P450单加氧酶的活性。 |
| Application3 | 柚皮苷可防止毒素诱导的细胞骨架破坏和凋亡性肝细胞死亡。 |
| 警示图 | |
| 危险性 | warning |
| 危险性警示 | No data available |
| 安全声明 | H315,H319,H335 |
| 安全防护 | P261,P305+P351+P338 |
| 备注 | 实验过程中防止吸入、食入，做好安全防护 |
| 象形图 |  |
|---|---|
| 信号 | Warning |
| GHS危险说明 |
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| 防范说明代码 |
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Tanaka S, Sato T, Akimoto N, Yano M, Ito A: Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro. Biochem Pharm |
| Zhang J, Brodbelt JS: Screening flavonoid metabolites of naringin and narirutin in urine after human consumption of grapefruit juice by LC-MS and LC-MS/MS. Analyst. 2004 Dec;129(12):1227-33. Epub 2004 |
| Ishii K, Furuta T, Kasuya Y: Determination of naringin and naringenin in human plasma by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1996 Aug 30;683(2):225-9. |
| Minagawa A, Otani Y, Kubota T, Wada N, Furukawa T, Kumai K, Kameyama K, Okada Y, Fujii M, Yano M, Sato T, Ito A, Kitajima M: The citrus flavonoid, nobi |
| Ishii K, Furuta T, Kasuya Y: Mass spectrometric identification and high-performance liquid chromatographic determination of a flavonoid glycoside naringin in human urine. J Agric Food Chem. 2000 Jan; |
1.Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats.
Gürsul C1, Ekinci Akdemir FN2, Akkoyun T3, Can ?4, Gül M5, Gülçin ?6,7. J Enzyme Inhib Med Chem. 2016 Apr 7:1-6. [Epub ahead of print]
This study was designed to investigate the antioxidant effects of Naringin, in ischemia/reperfusion (I/R)-induced skeletal muscle injury in rats. The rats were randomly allocated into three groups including control, I/R and I/R + Naringin groups. Muscle tissues of I/R groups revealed significantly higher antioxidant enzyme activities, and increased levels of malondialdehyde, as specific a marker of the lipid peroxidation and tissue damage, compared to the control group (p < 0.05). Levels of these parameters in muscle revealed significant reductions in the I/R + Naringin group compared to the I/R group (p < 0.05). Histopathological examination of ischemia muscles in the I/R group showed significant degeneration and inflammation compared to the control group, whereas ischemic muscles of Naringin-administered group showed significant reduction in degeneration and inflammation compared to the I/R group (p < 0.05). We suggest that the protective effect of Naringin may reduce the I/R injury in cases of extremity injuries with acute vascular complications, extremity surgery with prolonged tourniquet application.
2.NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation.
Yoshinaga A1, Kajiya N1, Oishi K1, Kamada Y1, Ikeda A1, Chigwechokha PK2, Kibe T3, Kishida M3, Kishida S3, Komatsu M2, Shiozaki K4. Eur J Pharmacol. 2016 Apr 19. pii: S0014-2999(16)30249-7. doi: 10.1016/j.ejphar.2016.04.035. [Epub ahead of print]
Naringin, which is one of the flavonoids contained in citrus fruits, is well known to possess various healthy functions to humans. It has been reported that naringin suppresses cancer cell growth in vitro and in vivo, although the underlying mechanisms are not fully understood. Recently, the roles of glycoconjugates, such as gangliosides, in cancer cells have been focused because of their regulatory effects of malignant phenotypes. Here, to clarify the roles of naringin in the negative-regulation of cancer cell growth, the alteration of glycoconjugates induced by naringin exposure and its significance on cell signaling were investigated. Human cancer cells, HeLa and A549, were exposed to various concentrations of naringin. Naringin treatment induced the suppression of cell growth toward HeLa and A549 cells accompanied with an increase of apoptotic cells. In naringin-exposed cells, GM3 ganglioside was drastically increased compared to the GM3 content prior to the treatment.
3.Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1.
Adil M1, Kandhare AD1, Ghosh P1, Venkata S1, Raygude KS1, Bodhankar SL1. Ren Fail. 2016 Apr 6:1-14. [Epub ahead of print]
CONTEXT: Acetaminophen (APAP) is an analgesic and antipyretic agent commonly known agent to cause hepatic and renal toxicity at a higher dose. Naringin, a bioflavonoid possesses multiple pharmacological properties such as antioxidant, anti-inflammatory, analgesic and anti-hyperlipidemic activity.
4.In vitro effects of the citrus flavonoids diosmin, naringenin and naringin on the hepatic drug-metabolizing CYP3A enzyme in human, pig, mouse and fish.
Burkina V1, Zlabek V2, Halsne R3, Ropstad E4, Zamaratskaia G5. Biochem Pharmacol. 2016 Apr 20. pii: S0006-2952(16)30065-X. doi: 10.1016/j.bcp.2016.04.011. [Epub ahead of print]
Flavonoids are known to have effects on cytochrome P450 enzymatic activity. However, little effort has been made to examine species differences and the relevance of studies on mammalian and fish microsomes so that extrapolations can be made to humans. Therefore, the effects of several naturally occurring flavonoids on the activity of CYP3A-dependent 7-benzyloxy- 4-trifluoromethylcoumarinO-debenzylase (BFCOD) were evaluated in human, pig, mouse, and juvenile rainbow trout sources of hepatic microsomes. Each was exposed to three concentrations (1, 10, and 100 μM) diosmin, naringin, and naringenin. Naringenin competitively inhibited BFCOD activity (Ki values were 24.6 μM in human, 15.6 μM in pig, and19.6 μM in mouse microsomes). In fish, BFCOD activity was inhibited in a noncompetitive manner (Ki = 7 μM). Neither diosmin nor naringenin affected BFCOD activity in hepatic microsomes from the studied model organisms. These results suggest that dietary flavonoids potentially inhibit metabolism of clinical drugs.
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