18588-57-3|Etoprine|2,4-Diamino-5-(3,4-dichlorophenyl)-6-ethylpyrimidine|-范德生物科技公司

Etoprine

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names：
2,4-Diamino-5-(3,4-dichlorophenyl)-6-ethylpyrimidine
CAS号：
18588-57-3
MDL Number：
MF(分子式)： C12H12Cl2N4 MW(分子量)： 283.156
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Etoprine
英文别名	Etoprine; DDEP; Ethodichlorophen;
CAS号	18588-57-3
SMILES	CCC1=C(C2=CC=C(Cl)C(Cl)=C2)C(N)=NC(N)=N1
Inchi	InChI=1S/C12H12Cl2N4/c1-2-9-10(11(15)18-12(16)17-9)6-3-4-7(13)8(14)5-6/h3-5H,2H2,1H3,(H4,15,16,17,18)
InchiKey	PXLPCZJACKUXGP-UHFFFAOYSA-N
分子式 Formula	C12H12Cl2N4
分子量 Molecular Weight	283.156
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Etoprine(CAS:18588-57-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Etoprine has the contraceptive effects The antifertility action of etoprine may be related to its capacity to inhibit testicular DHFR and its high degree of lipophilicity.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Han XM, Lee G, Hefner C, Maher JJ, Correia MA. Heme-reversible impairment of CYP2B1/2 induction in heme-depleted rat hepatocytes in primary culture: translational control by a hepatic alpha-subunit of the eukaryotic initiation factor kinase? J Pharmacol Exp Ther. 2005 Jul;314(1):128-38. Epub 2005 Mar 15. Erratum in: J Pharmacol Exp Ther. 2005 Nov;315(2):970. PubMed PMID: 15769864.

[2]McNamee JP, Jurima-Romet M, Kobus SM, Marks GS. cDNA-expressed human cytochrome P450 isozymes. Inactivation by porphyrinogenic xenobiotics. Drug Metab Dispos. 1997 Apr;25(4):437-41. PubMed PMID: 9107543.

[3] Pills, shots, implants, vaccines: can the elusive sperm be reined in? Male contraceptive research extremely slow, but promising. Contracept Technol Update. 1995 Aug;16(8):93-8. PubMed PMID: 12290717.

[4] Malik NS, Matlin SA, Fried J, Pakyz RE, Consentino MJ. The contraceptive effects of etoprine on male mice and rats. J Androl. 1995 Mar-Apr;16(2):169-74. PubMed PMID: 7559148.

[5] Kennedy CH, Mason RP. A reexamination of the cytochrome P-450-catalyzed free radical production from a dihydropyridine. Evidence of trace transition metal catalysis. J Biol Chem. 1990 Jul 15;265(20):11425-8. PubMed PMID: 2164003.

6: Sugiyama K, Yao K, Rettie AE, Correia MA. Inactivation of rat hepatic cytochrome P-450 isozymes by 3,5-dicarbethoxy- 2,6-dimethyl-4-ethyl-1,4-dihydropyridine. Chem Res Toxicol. 1989 Nov-Dec;2(6):400-10. PubMed PMID: 2519730.7: Rosowsky A, Freisheim JH, Hynes JB, Queener SF, Bartlett M, Smith JW, Lazarus H, Modest EJ. Tricyclic 2,4-diaminopyrimidines with broad antifolate activity and the ability to inhibit Pneumocystis carinii growth in cultured human lung fibroblasts in the presence of leucovorin. Biochem Pharmacol. 1989 Aug 15;38(16):2677-84. PubMed PMID: 2788420.8: Lee JS, Jacobsen NE, Ortiz de Montellano PR. 4-alkyl radical extrusion in the cytochrome P-450-catalyzed oxidation of 4-alkyl-1,4-dihydropyridines. Biochemistry. 1988 Oct 4;27(20):7703-10. PubMed PMID: 3207701.9: Chow SA, Rickert DE, Fischer LJ. Evidence that drug metabolites are involved in cyproheptadine-induced loss of pancreatic insulin. J Pharmacol Exp Ther. 1988 Jul;246(1):143-9. PubMed PMID: 3292756.10: Correia MA, Litman DA, Lunetta JM. Drug-induced modulations of hepatic heme metabolism. Neurological consequences. Ann N Y Acad Sci. 1987;51

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