Calyculin A|Calyculin A, protein phosphatase inhibitor|101932-71-2|-范德生物科技公司

Calyculin A

Calyculin A
NMR and HPLC COA下载 MSDS下载
Names：
Calyculin A, protein phosphatase inhibitor
CAS号：
101932-71-2
MDL Number：
MF(分子式)： C50H81N4O15P MW(分子量)： 1009.18
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

Calyculin A, protein phosphatase inhibitor（101932-71-2）是一种强效、选择性和细胞渗透性蛋白磷酸酶抑制剂（PP1 和 PP2A 的 IC50 值分别为 2 和 1 nM）。对 PP2B 和 PP2C 具有高度选择性。在体内和体外都有活性。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
FMK12967-20ug	20ug	>98%	¥ 2500.00	¥ 2500.00		1-3days	- +	¥ 0.00

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询价

中文别名	Calyculin A;Calyculin-A;protein phosphatase inhibitor；蛋白磷酸酶抑制剂；protein phosphatase inhibitor
英文别名	Calyculin A; Hemicalyculin A;
CAS号	101932-71-2
SMILES	O[C@@H]([C@H]([C@@H](N(C)C)COC)O)C(NCC[C@@H](C1=NC(/C=C/C[C@@H]([C@@H](C)[C@H](O)C2)O[C@@]32C(C)(C)[C@@H](OP(O)(O)=O)[C@@H]([C@@H](OC)C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C(C)=C/C=C/C(C)=C\C#N)O3)=CO1)C)=O
Inchi	InChI=1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-35,37-46,55-59H,19,21,23,25-26,28H2,1-13H3,(H,52,60)(H2,61,62,63)/b16-14+,18-15+,29-20-,30-17+,32-24+/t31-,33+,34-,35-,37-,38-,39+,40-,41-,42+,43-,44-,45+,46-,50+/m0/s1
InchiKey	FKAWLXNLHHIHLA-YCBIHMBMSA-N
分子式 Molecular Weight	C50H81N4O15P
分子量 Formula	1009.18
闪点 FP	No data available
熔点 Melting point	No data available
沸点 Boiling point	No data available
Polarizability极化度
密度 Density	No data available
蒸汽压 Vapor Pressure
溶解度Solubility	Soluble in ethanol and in DMSO
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

Calyculin A, protein phosphatase inhibitor - Functional Studies
Calyculin A 抑制乳腺癌上皮 MCF7 细胞的生长。将细胞与不同浓度的 Calyculin A 一起孵育四天。细胞数采用亚甲蓝法测定。相对于对照 (100%) 对细胞数进行标准化，并针对 Calyculin A 浓度作图。

产品说明	Calyculin A（101932-71-2）是一种强效、选择性和细胞渗透性蛋白磷酸酶抑制剂（PP1 和 PP2A 的 IC50 值分别为 2 和 1 nM）。对 PP2B 和 PP2C 具有高度选择性。在体内和体外都有活性。
Introduction	Calyculin A is a natural, cell-permeable inhibitor of the serine-threonine protein phosphatases (PP) PP1 and PP2A (IC50s = 0.3-0.7 and 0.5-1 nM, respectively). It is without significant effect against PP2B, PP2C, and PP4.2 Through its effects on PP1 and PP2A, calyculin A has been shown to either promote or inhibit cancer cell growth in tumor cell lines and animal models.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wakimoto T, Egami Y, Nakashima Y, Wakimoto Y, Mori T, Awakawa T, Ito T, Kenmoku H, Asakawa Y, Piel J, Abe I. Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont. Nat Chem Biol. 2014 Aug;10(8):648-55. doi: 10.1038/nchembio.1573. Epub 2014 Jun 29. PubMed PMID: 24974231.

[2]Almasry M, Jemaà M, Mischitelli M, Faggio C, Lang F. Stimulation of Suicidal Erythrocyte Death by Phosphatase Inhibitor Calyculin A. Cell Physiol Biochem. 2016;40(1-2):163-171. Epub 2016 Nov 18. PubMed PMID: 27855413.

[3] Chartier L, Rankin LL, Allen RE, Kato Y, Fusetani N, Karaki H, Watabe S, Hartshorne DJ. Calyculin-A increases the level of protein phosphorylation and changes the shape of 3T3 fibroblasts. Cell Motil Cytoskeleton. 1991;18(1):26-40. PubMed PMID: 1848484.

[4] Edelson JR, Brautigan DL. The Discodermia calyx toxin calyculin a enhances cyclin D1 phosphorylation and degradation, and arrests cell cycle progression in human breast cancer cells. Toxins (Basel). 2011 Jan;3(1):105-19. doi: 10.3390/toxins3010105. Epub 2011 Jan 24. PubMed PMID: 22069692; PubMed Central PMCID: PMC3210456.

[5] Gutierrez LM, Quintanar JL, Rueda J, Viniegra S, Reig JA. The protein phosphatase inhibitor calyculin-A affects catecholamine secretion and granular distribution in cultured adrenomedullary chromaffin cells. Eur J Cell Biol. 1995 Sep;68(1):88-95. PubMed PMID: 8549595.

6: Holy M, Brautigan DL. Calyculin A from Discodermia calyx is a dual action toxin that blocks calcium influx and inhibits protein Ser/Thr phosphatases. Toxins (Basel). 2012 Oct;4(10):940-54. doi: 10.3390/toxins4100940. Epub 2012 Oct 22. PubMed PMID: 23162706; PubMed Central PMCID: PMC3496997.7: Leopoldt D, Yee HF Jr, Rozengurt E. Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells. J Cell Physiol. 2001 Jul;188(1):106-19. PubMed PMID: 11382927.8: Pozuelo-Rubio M, Leslie NR, Murphy J, Mackintosh C. Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A. Cell Biochem Biophys. 2010 Dec;58(3):147-56. doi: 10.1007/s12013-010-9101-4. PubMed PMID: 20717744; PubMed Central PMCID: PMC3627045.9: Yu G, Li Y, Tian Q, Liu R, Wang Q, Wang JZ, Wang X. Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells. J Alzheimers Dis. 2011;24(3):525-35. doi: 10.3233/JAD-2011-101779. PubMed PMID: 21297267.10: Kramer JM, Evans A, Drury K, Moore K. Calyculin-A improves chromosome condensation for cytogenetic analysis of blastomeres from bovine and murine eight-cell stage embryos. Theriogenology. 2008 Sep 1;70(4):692-703. doi: 10.1016/j.theriogenology.2008.04.048. Epub 2008 Jun 16. PubMed PMID: 18556054.1

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